Essential oils and essential oil compounds in animal production as antimicrobials and anthelmintics: an updated review.

IF 4.3 2区 农林科学 Q1 VETERINARY SCIENCES Animal Health Research Reviews Pub Date : 2023-06-01 Epub Date: 2023-07-04 DOI:10.1017/S1466252322000093
Eduardo Henrique Custódio Matté, Fernando Bittencourt Luciano, Alberto Gonçalves Evangelista
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引用次数: 1

Abstract

Several countries have shown an increased prevalence of drug resistance in animal production due to the indiscriminate use of antibiotics and antiparasitics in human and veterinary medicine. This article aims to review existing methods using naturally occurring essential oils (EOs) and their isolated compounds (EOCs) as alternatives to antimicrobials and antiparasitic compounds in animal production and, consequently, to avoid resistance. The most-reported mechanism of action of EOs and EOCs was cell membrane damage, which leads to the leakage of cytoplasmic content, increased membrane permeability, inhibition of metabolic and genetic pathways, morphologic changes, antibiofilm effects, and damage to the genetic material of infections. In parasites, anticoccidial effects, reduced motility, growth inhibition, and morphologic changes have been reported. Although these compounds regularly show a similar effect to those promoted by traditional drugs, the elucidation of their mechanisms of action is still scarce. The use of EOs and EOCs can also positively influence crucial parameters in animal production, such as body weight gain, feed conversion rate, and cholesterol reduction, which also positively impact meat quality. The application of EOs and EOCs is enhanced by their association with other natural compounds or even by the association with synthetic chemicals, which has been found to cause synergism in their antimicrobial effect. By reducing the effective therapeutical/prophylactic dose, the chances of off-flavors – the most common issue in EO and EOC application – is greatly mitigated. However, there is very little work on the combination of EOs and EOCs in large in vivo studies. In addition, research must apply the correct methodology to properly understand the observed effects; for example, the use of only high concentrations may mask potential results obtained at lower dosages. Such corrections will also allow the elucidation of finer mechanisms and promote better biotechnologic use of EOs and EOCs. This manuscript presents several information gaps to be filled before the use of EOs and EOCs are fully applicable in animal production.

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动物生产中用作抗菌剂和驱虫剂的精油和精油化合物:最新综述。
由于在人类和兽医中滥用抗生素和抗寄生虫药物,一些国家的动物生产中耐药性的流行率有所上升。本文旨在综述在动物生产中使用天然精油及其分离化合物作为抗菌剂和抗寄生虫化合物的替代品的现有方法,从而避免耐药性。EOs和EOCs的作用机制最为报道的是细胞膜损伤,它导致细胞质内容物的渗漏、膜通透性的增加、代谢和遗传途径的抑制、形态学变化、抗生物膜作用以及对感染遗传物质的损伤。据报道,寄生虫具有抗球虫作用、运动能力下降、生长抑制和形态学变化。尽管这些化合物经常表现出与传统药物类似的效果,但对其作用机制的阐明仍然很少。EOs和EOCs的使用也会对动物生产中的关键参数产生积极影响,如体重增加、饲料转化率和胆固醇降低,这也会对肉质产生积极影响。EOs和EOCs与其他天然化合物的结合,甚至与合成化学物质的结合,增强了它们的应用,已经发现它们的抗菌作用具有协同作用。通过减少有效的治疗/预防剂量,可以大大降低EO和EOC应用中最常见的问题——异味的几率。然而,在大型体内研究中,关于EOs和EOCs组合的工作很少。此外,研究必须采用正确的方法来正确理解观察到的效果;例如,仅使用高浓度可能掩盖在较低剂量下获得的潜在结果。这种校正也将有助于阐明更精细的机制,并促进EOs和EOCs在生物技术上的更好应用。在EOs和EOC完全适用于动物生产之前,这份手稿提出了几个需要填补的信息空白。
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来源期刊
Animal Health Research Reviews
Animal Health Research Reviews VETERINARY SCIENCES-
CiteScore
6.70
自引率
0.00%
发文量
8
期刊介绍: Animal Health Research Reviews provides an international forum for the publication of reviews and commentaries on all aspects of animal health. Papers include in-depth analyses and broader overviews of all facets of health and science in both domestic and wild animals. Major subject areas include physiology and pharmacology, parasitology, bacteriology, food and environmental safety, epidemiology and virology. The journal is of interest to researchers involved in animal health, parasitologists, food safety experts and academics interested in all aspects of animal production and welfare.
期刊最新文献
Recent advances in the use of bacterial probiotics in animal production Alternatives to antibiotics in veterinary medicine: considerations for the management of Johne's disease. Essential oils and essential oil compounds in animal production as antimicrobials and anthelmintics: an updated review. Evidence that ectoparasites influence the hematological parameters of the host: a systematic review. Applications of butyric acid in poultry production: the dynamics of gut health, performance, nutrient utilization, egg quality, and osteoporosis - CORRIGENDUM.
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