{"title":"Association between sarcopenia with incident cardio-cerebrovascular disease: A systematic review and meta-analysis.","authors":"Miao Fang, Chunhua Liu, Yuan Liu, Guo Tang, Chunling Li, Lei Guo","doi":"10.5582/bst.2023.01130","DOIUrl":null,"url":null,"abstract":"<p><p>Sarcopenia is an age-associated skeletal muscle disease characterized by the progressive loss of muscle mass and function. The objective of this systematic review and meta-analysis was to evaluate the associations between sarcopenia and cardio-cerebrovascular disease (CCVD). A comprehensive search of the PubMed/Medline, Embase, Web of Science, Scopus, and Cochrane Library databases was conducted from their inception to April 1<sup>st</sup>, 2023. A total of eight cross-sectional studies involving 63,738,162 participants met the inclusion criteria. Pooled estimates of odds ratios (ORs) were calculated using random-effects models. The findings demonstrated a significant association between sarcopenia and an increased risk of CCVD (OR: 1.33, 95% CI: 1.18 - 1.50, I<sup>2</sup> = 1%; p < 0.001). Subgroup analyses indicated that sarcopenia was associated with a 1.67-fold increase in the risk of stroke and a 1.31-fold increase in the risk of CVD. Four studies included in this review examined the association between sarcopenic obesity and the risk of CCVD, and the results revealed that sarcopenic obesity was associated with a higher risk of CCVD (OR: 1.64, 95% CI: 1.08 - 2.49, I<sup>2</sup> = 69%; p < 0.001). Meta-regressions and sensitivity analyses consistently supported the robustness of the overall findings. In conclusion, sarcopenia and sarcopenic obesity are significantly associated with an elevated risk of developing CCVD. However, further prospective cohort studies are warranted to validate this relationship while controlling for confounding factors.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":"17 4","pages":"293-301"},"PeriodicalIF":5.7000,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience trends","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.5582/bst.2023.01130","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
Sarcopenia is an age-associated skeletal muscle disease characterized by the progressive loss of muscle mass and function. The objective of this systematic review and meta-analysis was to evaluate the associations between sarcopenia and cardio-cerebrovascular disease (CCVD). A comprehensive search of the PubMed/Medline, Embase, Web of Science, Scopus, and Cochrane Library databases was conducted from their inception to April 1st, 2023. A total of eight cross-sectional studies involving 63,738,162 participants met the inclusion criteria. Pooled estimates of odds ratios (ORs) were calculated using random-effects models. The findings demonstrated a significant association between sarcopenia and an increased risk of CCVD (OR: 1.33, 95% CI: 1.18 - 1.50, I2 = 1%; p < 0.001). Subgroup analyses indicated that sarcopenia was associated with a 1.67-fold increase in the risk of stroke and a 1.31-fold increase in the risk of CVD. Four studies included in this review examined the association between sarcopenic obesity and the risk of CCVD, and the results revealed that sarcopenic obesity was associated with a higher risk of CCVD (OR: 1.64, 95% CI: 1.08 - 2.49, I2 = 69%; p < 0.001). Meta-regressions and sensitivity analyses consistently supported the robustness of the overall findings. In conclusion, sarcopenia and sarcopenic obesity are significantly associated with an elevated risk of developing CCVD. However, further prospective cohort studies are warranted to validate this relationship while controlling for confounding factors.
肌萎缩是一种与年龄相关的骨骼肌疾病,其特征是肌肉质量和功能的逐渐丧失。本系统综述和荟萃分析的目的是评估少肌症与心脑血管疾病(CCVD)之间的关系。从成立到2023年4月1日,对PubMed/Medline、Embase、Web of Science、Scopus和Cochrane Library数据库进行了全面搜索。共有8项横断面研究,涉及63738162名参与者,符合纳入标准。使用随机效应模型计算比值比(OR)的汇总估计值。研究结果表明,少肌症与CCVD风险增加之间存在显著关联(OR:1.33,95%CI:1.18-1.50,I2=1%;p<0.001)。亚组分析表明,少肌肉症与中风风险增加1.67倍和CVD风险增加1.31倍有关。本综述中包括的四项研究检查了肌萎缩性肥胖与CCVD风险之间的关系,结果显示,肌萎缩性肥胖症与更高的CCVD风险相关(OR:1.64,95%CI:1.08-2.49,I2=69%;p<0.001)。荟萃回归和敏感性分析一致支持总体发现的稳健性。总之,少肌症和少肌性肥胖与患CCVD的风险升高显著相关。然而,在控制混杂因素的同时,有必要进行进一步的前瞻性队列研究来验证这种关系。
期刊介绍:
BioScience Trends (Print ISSN 1881-7815, Online ISSN 1881-7823) is an international peer-reviewed journal. BioScience Trends devotes to publishing the latest and most exciting advances in scientific research. Articles cover fields of life science such as biochemistry, molecular biology, clinical research, public health, medical care system, and social science in order to encourage cooperation and exchange among scientists and clinical researchers.