The effects of Korean Red Ginseng on heme oxygenase-1 with a focus on mitochondrial function in pathophysiologic conditions

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL Journal of Ginseng Research Pub Date : 2023-09-01 DOI:10.1016/j.jgr.2023.04.001

Chang-Hee Kim , Hahn Young Kim , Seung-Yeol Nah , Yoon Kyung Choi

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Abstract

Korean Red Ginseng (KRG) plays a key role in heme oxygenase (HO)-1 induction under physical and moderate oxidative stress conditions. The transient and mild induction of HO-1 is beneficial for cell protection, mitochondrial function, regeneration, and intercellular communication. However, chronic HO-1 overexpression is detrimental in severely injured regions. Thus, in a chronic pathological state, diminishing HO-1-mediated ferroptosis is beneficial for a therapeutic approach. The molecular mechanisms by which KRG protects various cell types in the central nervous system have not yet been established, especially in terms of HO-1-mediated mitochondrial functions. Therefore, in this review, we discuss the multiple roles of KRG in the regulation of astrocytic HO-1 under pathophysiological conditions. More specifically, we discuss the role of the KRG-mediated astrocytic HO-1 pathway in regulating mitochondrial functions in acute and chronic neurodegenerative diseases as well as physiological conditions.

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韩国红参对血红素加氧酶-1的影响，重点是病理生理条件下的线粒体功能

在物理和中度氧化应激条件下，韩国红参（KRG）在血红素加氧酶（HO）-1的诱导中起着关键作用。HO-1的短暂和温和诱导有利于细胞保护、线粒体功能、再生和细胞间通讯。然而，慢性HO-1过表达在严重损伤区域是有害的。因此，在慢性病理状态下，减少HO-1介导的脱铁性贫血对治疗方法是有益的。KRG保护中枢神经系统中各种细胞类型的分子机制尚未建立，特别是在HO-1介导的线粒体功能方面。因此，在这篇综述中，我们讨论了KRG在病理生理条件下调节星形细胞HO-1的多种作用。更具体地说，我们讨论了KRG介导的星形细胞HO-1通路在急性和慢性神经退行性疾病以及生理条件下调节线粒体功能的作用。

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.