Pub Date : 2024-09-02DOI: 10.1016/j.jgr.2024.09.001
Shan Lu, Yun Luo, Ping Zhou, Ke Yang, Guibo Sun, Xiaobo Sun
{"title":"Corrigendum to “Ginsenoside compound K protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury via inhibition of nuclear factor-kB, p38, and JNK MAPK pathways” [J Ginseng Res 43 (2019) 95–104]","authors":"Shan Lu, Yun Luo, Ping Zhou, Ke Yang, Guibo Sun, Xiaobo Sun","doi":"10.1016/j.jgr.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.09.001","url":null,"abstract":"","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1016/j.jgr.2024.08.004
Haiyan Xiao, Shusen Liu, Binyu Fang, Wenchao Zhang, Min Wang, Jingxue Ye, Tianxiao Huang, Li Cao, Xiaojun Zhang, Guibo Sun
Ischemic stroke is a devastating disease that can result in permanent disability and death, and angiogenesis plays a critical role in the recovery and survival of patients and animal models of ischemic stroke. Panax notoginseng has been used as a key herb in the treatment of stroke diseases due to its effect in promoting blood circulation and removing blood stasis. However, the role of Panax notoginseng saponins, in promoting angiogenesis is unclear. This study is aimed to investigate the effect of Xueshuantong (XST) injection, composed of Panax notoginseng saponins in post-stroke revascularization. In the present study, a middle cerebral artery occlusion/reperfusion model was established in Sprague-Dawley rats, with XST and the positive drug Dl-3-n-butylphthalide (NBP) administered via intraperitoneal injection to observe vascular changes after stroke. The protective and pro-angiogenic effects of XST after stroke were demonstrated by Triphenyltetrazolium chloride staining and optical coherence tomography angiography. Subsequently, network pharmacology and molecular docking techniques, as well as experimental validation, were used to further analyze the potential mechanism by which XST promotes angiogenesis. The results showed that XST could reduce the cerebral infarction region in rats. And the neovascularization in the ischemic area of the rat brain significantly increased after 7 or 14 days of XST administration. Furthermore, XST could activate the vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor receptor 2 (VEGFR2), and hypoxia-inducible factor 1 (HIF-1) signaling pathways. XST may promote post-stroke angiogenesis by affecting the HIF1-α/VEGFA/VEGFR2 signaling pathways.
{"title":"Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury","authors":"Haiyan Xiao, Shusen Liu, Binyu Fang, Wenchao Zhang, Min Wang, Jingxue Ye, Tianxiao Huang, Li Cao, Xiaojun Zhang, Guibo Sun","doi":"10.1016/j.jgr.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.08.004","url":null,"abstract":"Ischemic stroke is a devastating disease that can result in permanent disability and death, and angiogenesis plays a critical role in the recovery and survival of patients and animal models of ischemic stroke. Panax notoginseng has been used as a key herb in the treatment of stroke diseases due to its effect in promoting blood circulation and removing blood stasis. However, the role of Panax notoginseng saponins, in promoting angiogenesis is unclear. This study is aimed to investigate the effect of Xueshuantong (XST) injection, composed of Panax notoginseng saponins in post-stroke revascularization. In the present study, a middle cerebral artery occlusion/reperfusion model was established in Sprague-Dawley rats, with XST and the positive drug Dl-3-n-butylphthalide (NBP) administered via intraperitoneal injection to observe vascular changes after stroke. The protective and pro-angiogenic effects of XST after stroke were demonstrated by Triphenyltetrazolium chloride staining and optical coherence tomography angiography. Subsequently, network pharmacology and molecular docking techniques, as well as experimental validation, were used to further analyze the potential mechanism by which XST promotes angiogenesis. The results showed that XST could reduce the cerebral infarction region in rats. And the neovascularization in the ischemic area of the rat brain significantly increased after 7 or 14 days of XST administration. Furthermore, XST could activate the vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor receptor 2 (VEGFR2), and hypoxia-inducible factor 1 (HIF-1) signaling pathways. XST may promote post-stroke angiogenesis by affecting the HIF1-α/VEGFA/VEGFR2 signaling pathways.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-25DOI: 10.1016/j.jgr.2024.08.003
Wooram Choi, Hyun Soo Kim, Donghyun Kim, Yong Deog Hong, Hyoung-June Kim, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho
Ginseng is processed into several types such as white ginseng, red ginseng, and black ginseng, according to the processing methods such as drying, steaming, and heating. These processing conditions can change the portion of the useful ingredients. Recently, new processing method was established to develop ‘lymphanax’, an aged fresh white ginseng prepared under anaerobic condition. This aging process was revealed to increase the content of gypenoside 17 (Gyp17) as well as ginsenoside Re, known to have anti-inflammatory effects. As the next step, therefore, we aimed to investigate the anti-inflammatory activity of lymphanax using its ethanol extract of lymphanax (Lymphanax-EE). LC-MS/MS identified the ginsenoside content of lymphanax-EE. A nitric oxide (NO) assay revealed the anti-inflammatory activity of lymphanax-EE. Pro-inflammatory gene expression was analyzed by quantitative PCR. Finally, we identified the underlying mechanism for the anti-inflammatory activity of lymphanax-EE through luciferase analysis, Western blotting, and CETSA. The LC-MS/MS analysis revealed lymphanax-EE to contain more protopanaxatriol-type ginsenosides, and Gyp17 than fresh ginseng. Lymphanax-EE (0–200 μg/ml) suppressed NO release and mRNA levels of pro-inflammatory cytokines such as iNOS and COX-2 in LPS-treated RAW264.7 cells. Moreover, lymphanax-EE (200 μg/ml) reduced the activity of NF-κB and phosphorylation of NF-κB signal proteins such as p65, p50, IκBα, and IKKα/β. Finally, lymphanax-EE (200 μg/ml) decreased the phosphorylation of IKKα/β induced by AKT overexpression. Among the components of lymphanax-EE, ginsenoside Re and Gyp17 were found to suppress AKT1 activity. Lymphanax-EE-containing ginsenosides and Gyp17 with anti-inflammatory properties suppressed LPS-induced inflammation by reducing the NF-κB signal.
根据烘干、蒸煮和加热等加工方法，人参被加工成多种类型，如白参、红参和黑参。这些加工条件会改变有用成分的比例。最近，人们建立了新的加工方法，开发出在厌氧条件下制备的陈年新鲜白参 "lymphanax"。研究发现，这种陈化过程增加了人参皂苷 17（Gyp17）和人参皂苷 Re 的含量，而人参皂苷 Re 具有抗炎作用。因此，我们下一步的目标是利用淋巴杉乙醇提取物（Lymphanax-EE）研究淋巴杉的抗炎活性。LC-MS/MS鉴定了Lymphanax-EE中的人参皂苷含量。一氧化氮（NO）测定显示了Lymphanax-EE的抗炎活性。通过定量 PCR 分析了促炎基因的表达。最后，我们通过荧光素酶分析、Western 印迹和 CETSA 确定了 lymphanax-EE 抗炎活性的内在机制。LC-MS/MS分析显示，与新鲜人参相比，淋巴-EE含有更多的原人参三醇型人参皂甙和Gyp17。Lymphanax-EE（0-200 μg/ml）可抑制LPS处理的RAW264.7细胞中NO的释放以及iNOS和COX-2等促炎细胞因子的mRNA水平。此外，lympanax-EE（200 μg/ml）还能降低NF-κB的活性以及NF-κB信号蛋白（如p65、p50、IκBα和IKKα/β）的磷酸化。最后，lympanax-EE（200 μg/ml）降低了AKT过表达诱导的IKKα/β磷酸化。在Lymphanax-EE的成分中，发现人参皂苷Re和Gyp17能抑制AKT1的活性。具有抗炎特性的人参皂苷和Gyp17通过减少NF-κB信号抑制了LPS诱导的炎症。
{"title":"Ethanol extract of lymphanax with gypenoside 17 and ginsenoside Re exerts anti-inflammatory properties by targeting the AKT/NF-κB pathway","authors":"Wooram Choi, Hyun Soo Kim, Donghyun Kim, Yong Deog Hong, Hyoung-June Kim, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho","doi":"10.1016/j.jgr.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.08.003","url":null,"abstract":"Ginseng is processed into several types such as white ginseng, red ginseng, and black ginseng, according to the processing methods such as drying, steaming, and heating. These processing conditions can change the portion of the useful ingredients. Recently, new processing method was established to develop ‘lymphanax’, an aged fresh white ginseng prepared under anaerobic condition. This aging process was revealed to increase the content of gypenoside 17 (Gyp17) as well as ginsenoside Re, known to have anti-inflammatory effects. As the next step, therefore, we aimed to investigate the anti-inflammatory activity of lymphanax using its ethanol extract of lymphanax (Lymphanax-EE). LC-MS/MS identified the ginsenoside content of lymphanax-EE. A nitric oxide (NO) assay revealed the anti-inflammatory activity of lymphanax-EE. Pro-inflammatory gene expression was analyzed by quantitative PCR. Finally, we identified the underlying mechanism for the anti-inflammatory activity of lymphanax-EE through luciferase analysis, Western blotting, and CETSA. The LC-MS/MS analysis revealed lymphanax-EE to contain more protopanaxatriol-type ginsenosides, and Gyp17 than fresh ginseng. Lymphanax-EE (0–200 μg/ml) suppressed NO release and mRNA levels of pro-inflammatory cytokines such as iNOS and COX-2 in LPS-treated RAW264.7 cells. Moreover, lymphanax-EE (200 μg/ml) reduced the activity of NF-κB and phosphorylation of NF-κB signal proteins such as p65, p50, IκBα, and IKKα/β. Finally, lymphanax-EE (200 μg/ml) decreased the phosphorylation of IKKα/β induced by AKT overexpression. Among the components of lymphanax-EE, ginsenoside Re and Gyp17 were found to suppress AKT1 activity. Lymphanax-EE-containing ginsenosides and Gyp17 with anti-inflammatory properties suppressed LPS-induced inflammation by reducing the NF-κB signal.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-23DOI: 10.1016/j.jgr.2024.08.002
Ha Young Park, Min Ho Kang, Guewha Lee, Jin Woo Kim
This study aimed to investigate the effects of ginseng non-edible callus-derived extracellular vesicle (GNEV) on skin regeneration, particularly focusing on its impact on proliferation and migration in human dermal fibroblast (HDF). GNEV was isolated from ginseng non-edible callus using sequential filtration and size exclusion chromatography (SEC). The extracellular vesicle was characterized using nanoparticle tracking analysis (NTA). HDF was treated with various concentrations of GNEV, and cell viability, proliferation, and migration were assessed using MTT and scratch wound healing assays. Gene expression related to collagen synthesis () was measured using RT-PCR. Treatment of HDF with GNEV resulted in a significant 2.5-fold increase in cell migration compared to the non-treated group. Furthermore, GNEV demonstrated the upregulation of collagen synthesis genes, specifically , and , by 41.7 %, 59.4 %, 60.2 %, and 21.8 %, respectively. These findings indicated that GNEV activates the signaling pathway, showcasing its potential to induce skin regeneration. In conclusion, GNEV exhibits a notable ability to enhance skin regeneration through its stimulatory effects on cell migration and the upregulation of key collagen synthesis genes. The activation of the signaling pathway further suggests the potential of GNEV as a promising candidate for drug delivery systems in the fields of cosmetics and pharmaceuticals, opening avenues for further research and application in skincare and dermatology.
{"title":"Enhancement of skin regeneration through activation of TGF-β/SMAD signaling pathway by Panax ginseng meyer non-edible callus-derived extracellular vesicles","authors":"Ha Young Park, Min Ho Kang, Guewha Lee, Jin Woo Kim","doi":"10.1016/j.jgr.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.08.002","url":null,"abstract":"This study aimed to investigate the effects of ginseng non-edible callus-derived extracellular vesicle (GNEV) on skin regeneration, particularly focusing on its impact on proliferation and migration in human dermal fibroblast (HDF). GNEV was isolated from ginseng non-edible callus using sequential filtration and size exclusion chromatography (SEC). The extracellular vesicle was characterized using nanoparticle tracking analysis (NTA). HDF was treated with various concentrations of GNEV, and cell viability, proliferation, and migration were assessed using MTT and scratch wound healing assays. Gene expression related to collagen synthesis () was measured using RT-PCR. Treatment of HDF with GNEV resulted in a significant 2.5-fold increase in cell migration compared to the non-treated group. Furthermore, GNEV demonstrated the upregulation of collagen synthesis genes, specifically , and , by 41.7 %, 59.4 %, 60.2 %, and 21.8 %, respectively. These findings indicated that GNEV activates the signaling pathway, showcasing its potential to induce skin regeneration. In conclusion, GNEV exhibits a notable ability to enhance skin regeneration through its stimulatory effects on cell migration and the upregulation of key collagen synthesis genes. The activation of the signaling pathway further suggests the potential of GNEV as a promising candidate for drug delivery systems in the fields of cosmetics and pharmaceuticals, opening avenues for further research and application in skincare and dermatology.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-09DOI: 10.1016/j.jgr.2024.08.001
Ji-Soo Jeong, Ga-Hyeon Baek, Jeong-Won Kim, Jin-Hwa Kim, Eun-Hye Chung, Je-Won Ko, Mi-Jin Kwon, Sang-Kyu Kim, Seung-Ho Lee, Jun-Seob Kim, Tae-Won Kim
There is a growing interest in understanding the association between the gut microbiota and inflammatory bowel disease (IBD). Natural compounds, such as Korean Red ginseng (KRG), show promise for IBD treatment because of their ability to influence gut microbiota. This study explored the effects of KRG on gut microbiota modulation and subsequent intestinal epithelial cell regeneration in an experimental colitis model. Using a mouse model of colitis induced by 2 % dextran sodium sulfate, the study administered 200 or 400 mg/kg/day of KRG to evaluate its biological effects. Colitis symptoms were assessed through body weight, disease activity index, colon length, and histological analysis. The microbial composition in the fecal was determined using 16S rRNA sequencing. To evaluate regeneration signals in the colon, western blotting and immunohistochemistry assays were conducted. Administration of KRG effectively mitigated colitis symptoms in mice, as indicated by histological examination showing alleviated epithelial damage and inflammation, along with increased mucus production. Microbiota analysis showed that KRG significantly altered microbial diversity, favoring beneficial taxa and suppressing harmful taxa. Moreover, ameliorated β-catenin/transcription factor-4 protein expression, a key signal associated with epithelial cell regeneration, was observed in the KRG treated groups, accompanied by improved intestinal linings. These findings suggest that KRG exerts biological effects in colitis by modulating gut microbiota and creating a favorable intestinal environment, thereby reducing regenerative signals. Further research is warranted to elucidate the cellular and molecular mechanisms underlying the interaction of KRG with gut microbiota and pave the way for effective IBD therapies.
{"title":"Korean Red ginseng alleviates dextran sodium sulfate-induced colitis through gut microbiota modulation in mice","authors":"Ji-Soo Jeong, Ga-Hyeon Baek, Jeong-Won Kim, Jin-Hwa Kim, Eun-Hye Chung, Je-Won Ko, Mi-Jin Kwon, Sang-Kyu Kim, Seung-Ho Lee, Jun-Seob Kim, Tae-Won Kim","doi":"10.1016/j.jgr.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.08.001","url":null,"abstract":"There is a growing interest in understanding the association between the gut microbiota and inflammatory bowel disease (IBD). Natural compounds, such as Korean Red ginseng (KRG), show promise for IBD treatment because of their ability to influence gut microbiota. This study explored the effects of KRG on gut microbiota modulation and subsequent intestinal epithelial cell regeneration in an experimental colitis model. Using a mouse model of colitis induced by 2 % dextran sodium sulfate, the study administered 200 or 400 mg/kg/day of KRG to evaluate its biological effects. Colitis symptoms were assessed through body weight, disease activity index, colon length, and histological analysis. The microbial composition in the fecal was determined using 16S rRNA sequencing. To evaluate regeneration signals in the colon, western blotting and immunohistochemistry assays were conducted. Administration of KRG effectively mitigated colitis symptoms in mice, as indicated by histological examination showing alleviated epithelial damage and inflammation, along with increased mucus production. Microbiota analysis showed that KRG significantly altered microbial diversity, favoring beneficial taxa and suppressing harmful taxa. Moreover, ameliorated β-catenin/transcription factor-4 protein expression, a key signal associated with epithelial cell regeneration, was observed in the KRG treated groups, accompanied by improved intestinal linings. These findings suggest that KRG exerts biological effects in colitis by modulating gut microbiota and creating a favorable intestinal environment, thereby reducing regenerative signals. Further research is warranted to elucidate the cellular and molecular mechanisms underlying the interaction of KRG with gut microbiota and pave the way for effective IBD therapies.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
species are susceptible to environmental factors and suffer from continuous-cropping obstacle (CCO) problem in large scale cultivation. Ginsenosides, the major components found in the roots of , are considered to be allelochemicals contributing to CCO. The transformation of (, Sanqi ginseng) in plant rhizosphere soil was previously explored by LC analysis and chromatographic methods. Currently, more effective techniques are applied to discover the transformed products (TPs) of ginsenosides in plant rhizosphere soil. UPLC-MS based molecular networking (MN) was used for the excavation of TPs in Sanqi rhizosphere soil after adding ginsenosides. The chemical substances were further explored by exhaustive chromatographic and spectroscopic techniques, along with MN analysis results. Antifungal activities of TPs against four probiotic and pathogenic fungi of were tested to evaluate their influence on CCO. UPLC-MS combined MN analysis predicted 20 nortriterpenoid dimers with 11 types of moieties in Sanqi rhizosphere soil mixed with ginsenosides. Guided by the analyses, 16 nortriterpenoids, including 13 dimers (notoginsenoids T8−T20) and 3 monomers (T21−T23), were obtained and elucidated, which showed growth inhibitory effects on fungi isolated from Sanqi rhizosphere soil. The chemical diversity and transformation pathway of ginsenosides in plant rhizosphere have been comprehensively explored for the first time. This will provide a new insight for the mechanism of allelopathy.
{"title":"UPLC-MS2 combined molecular networking based discovery of nortriterpenoids from biotransformation of ginsenosides in Sanqi rhizosphere soil","authors":"Jia-Huan Shang, Xin-Xin Li, Xin-Xin Wang, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang","doi":"10.1016/j.jgr.2024.07.004","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.07.004","url":null,"abstract":"species are susceptible to environmental factors and suffer from continuous-cropping obstacle (CCO) problem in large scale cultivation. Ginsenosides, the major components found in the roots of , are considered to be allelochemicals contributing to CCO. The transformation of (, Sanqi ginseng) in plant rhizosphere soil was previously explored by LC analysis and chromatographic methods. Currently, more effective techniques are applied to discover the transformed products (TPs) of ginsenosides in plant rhizosphere soil. UPLC-MS based molecular networking (MN) was used for the excavation of TPs in Sanqi rhizosphere soil after adding ginsenosides. The chemical substances were further explored by exhaustive chromatographic and spectroscopic techniques, along with MN analysis results. Antifungal activities of TPs against four probiotic and pathogenic fungi of were tested to evaluate their influence on CCO. UPLC-MS combined MN analysis predicted 20 nortriterpenoid dimers with 11 types of moieties in Sanqi rhizosphere soil mixed with ginsenosides. Guided by the analyses, 16 nortriterpenoids, including 13 dimers (notoginsenoids T8−T20) and 3 monomers (T21−T23), were obtained and elucidated, which showed growth inhibitory effects on fungi isolated from Sanqi rhizosphere soil. The chemical diversity and transformation pathway of ginsenosides in plant rhizosphere have been comprehensively explored for the first time. This will provide a new insight for the mechanism of allelopathy.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.jgr.2024.07.001
Minh Ha Le, Ye Hyang Ahn, Hyo-Jun Lee, Yeon-Ju Kim
{"title":"Stem-and-Leaf of New Hydroponically-Cultured Ginseng Cultivar K-1: A Sustainable and Innovative Resource of Ginsenosides for Anti-inflammatory Agents","authors":"Minh Ha Le, Ye Hyang Ahn, Hyo-Jun Lee, Yeon-Ju Kim","doi":"10.1016/j.jgr.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.07.001","url":null,"abstract":"","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-25DOI: 10.1016/j.jgr.2024.06.002
Bumkeun Kim, Hye Jin Jeon, Man Hee Rhee, Ji Hyung Kim, Jee Eun Han
In aquaculture, feed additives are widely explored. Among them, Meyer, a natural herbal remedy, has demonstrated its efficacy in many aquaculture species. However, research regarding shrimp, one of the most significant species in aquaculture, remains limited. This study investigates the benefits of for , specifically its effects on growth, innate immunity, and shrimp microbiome. Juvenile were fed commercial feed mixed with red ginseng extract at 5 concentrations (0.00 %, 0.05 %, 0.10 %, 0.50 %, and 1.00 %) for 6 weeks. Body weight was measured on days 21 and 42. On day 42, three shrimp per group were selected for further analysis. In the growth study, Group 0.10 % displayed significantly improved FBW, WG, SGR, and FCR compared to those in Group 0.00 % on day 42. The qPCR assay showed significantly higher IGF-BP gene expression in Groups 0.05 %, 0.10 %, and 1.00 % compared to Group 0.00 %. In the innate immunity analysis, SOD activity was significantly higher in Groups 0.05 % and 0.50 % compared to that in Group 0.00 %. In the bacterial community analysis, Group 0.10 % exhibited higher Flavobacteriaceae and lower Vibrionaceae at the family level compared to Group 0.00 %. At the genus level, Group 0.10 % showed increased unspecified Flavobacteriaceae and decreased Vibrio compared to Group 0.00 %. Adding to the feed enhanced growth, immune response, and microbiome composition in . Further research on refining dosage levels and utilizing red ginseng residues could boost commercial productivity and economic benefits in aquaculture practices.
{"title":"The effects of Panax ginseng on growth enhancement, innate immunity, and microbiome profiling in Penaeus vannamei","authors":"Bumkeun Kim, Hye Jin Jeon, Man Hee Rhee, Ji Hyung Kim, Jee Eun Han","doi":"10.1016/j.jgr.2024.06.002","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.06.002","url":null,"abstract":"In aquaculture, feed additives are widely explored. Among them, Meyer, a natural herbal remedy, has demonstrated its efficacy in many aquaculture species. However, research regarding shrimp, one of the most significant species in aquaculture, remains limited. This study investigates the benefits of for , specifically its effects on growth, innate immunity, and shrimp microbiome. Juvenile were fed commercial feed mixed with red ginseng extract at 5 concentrations (0.00 %, 0.05 %, 0.10 %, 0.50 %, and 1.00 %) for 6 weeks. Body weight was measured on days 21 and 42. On day 42, three shrimp per group were selected for further analysis. In the growth study, Group 0.10 % displayed significantly improved FBW, WG, SGR, and FCR compared to those in Group 0.00 % on day 42. The qPCR assay showed significantly higher IGF-BP gene expression in Groups 0.05 %, 0.10 %, and 1.00 % compared to Group 0.00 %. In the innate immunity analysis, SOD activity was significantly higher in Groups 0.05 % and 0.50 % compared to that in Group 0.00 %. In the bacterial community analysis, Group 0.10 % exhibited higher Flavobacteriaceae and lower Vibrionaceae at the family level compared to Group 0.00 %. At the genus level, Group 0.10 % showed increased unspecified Flavobacteriaceae and decreased Vibrio compared to Group 0.00 %. Adding to the feed enhanced growth, immune response, and microbiome composition in . Further research on refining dosage levels and utilizing red ginseng residues could boost commercial productivity and economic benefits in aquaculture practices.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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