In Vivo Visualization of Macrophage-Like Cells in Patients with Uveitis by Use of En Face Swept Source Optical Coherence Tomography.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY Ocular Immunology and Inflammation Pub Date : 2024-10-01 Epub Date: 2023-09-18 DOI:10.1080/09273948.2023.2254369

Francesco Pichi, Piergiorgio Neri, Shaikha Aljeneibi, Steven Hay, Hannah Chaudhry, Maria Carmela Saturno, Ester Carreno

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Abstract

Aims: To detect macrophage-like cells (MLCs) in uveitis patients and describe their characteristics compared to healthy subjects by using en face SS-OCTA.

Methods: Fifteen consecutive patients with "active" uveitis and 11 healthy participants underwent 6 macular scans of 6×6mm using SS-OCTA. The 3μm en face OCT slabs on inner limiting membrane were used to visualize the MLCs.

Results: In healthy subjects there was an average of 478.2±149.7 MLCs with a density of 13.28±4.16 cells/mm². MLCs were larger in patients with "active" uveitis than in controls (891.18±69.46 µm² vs.885±77.53 µm²). Patients with "active" anterior uveitis had a significantly reduced count and density of MLCs (172±14.68 and 4.77±0.4 cell/mm²) compared to controls, while patients with posterior uveitis had a statistically increased count (546.1±132.4) and area (909.23+/-54.97 µm²) of MLCs compared to controls.

Conclusions: MLCs detected with en face SS-OCTA are increased in number and size in active posterior uveitis eyes compared to controls.

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利用面扫光源光学相干断层成像技术观察葡萄膜炎患者体内的巨噬细胞。

目的：使用en face SS-OCTA检测葡萄膜炎患者的巨噬细胞样细胞（MLCs），并描述其与健康人相比的特征：方法：15 名 "活动性 "葡萄膜炎患者和 11 名健康参与者接受了 6 次 6×6mm 的 SS-OCTA 黄斑扫描。结果：在健康受试者中，内缘膜上的 3μm en face OCT 厚片平均厚度为 0.5 mm，而在活动性葡萄膜炎患者中，平均厚度为 0.5 mm：健康受试者平均有 478.2±149.7 个 MLCs，密度为 13.28±4.16 cells/mm2。活动性 "葡萄膜炎患者的 MLC 比对照组大（891.18±69.46 µm2 对 885±77.53 µm2）。与对照组相比，"活动性 "前葡萄膜炎患者的 MLCs 数量和密度（172±14.68 和 4.77±0.4 cell/mm2）明显减少，而与对照组相比，后葡萄膜炎患者的 MLCs 数量（546.1±132.4）和面积（909.23+/-54.97 µm2）均有统计学意义的增加：与对照组相比，活动性后葡萄膜炎患者眼球内SS-OCTA检测到的MLC在数量和大小上都有所增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.

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