Immunotherapy for KSHV-associated diseases

IF 5.7 2区 医学 Q1 VIROLOGY Current opinion in virology Pub Date : 2022-08-01 DOI:10.1016/j.coviro.2022.101249
Kathryn Lurain, Robert Yarchoan, Ramya Ramaswami
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引用次数: 4

Abstract

Kaposi sarcoma herpesvirus (KSHV)-associated diseases (Kaposi sarcoma, multicentric Castleman disease, primary effusion lymphoma, and KSHV inflammatory cytokine syndrome) are associated with immune suppression and dysregulation and loss of KSHV-specific immunity. These diseases are most frequent in people living with HIV as well as those with primary or iatrogenic immune deficiencies. KSHV itself can modulate the immune system via viral homologs of host cytokines or downregulation of immune-surface markers altering host immune surveillance. These factors make KSHV-associated diseases prime targets for immunotherapy approaches. Several agents have been studied or are under investigation in KSHV-associated diseases, including monoclonal antibodies, immunomodulatory agents, and therapeutic cytokines. Here, we review the role of immunotherapies in KSHV-associated diseases.

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kshv相关疾病的免疫治疗
卡波西肉瘤疱疹病毒(KSHV)相关疾病(卡波西肉瘤、多中心Castleman病、原发性积液性淋巴瘤和KSHV炎性细胞因子综合征)与免疫抑制、失调和KSHV特异性免疫丧失有关。这些疾病最常见于艾滋病毒感染者以及原发性或医源性免疫缺陷患者。KSHV本身可以通过宿主细胞因子的病毒同源物或下调免疫表面标记物改变宿主免疫监视来调节免疫系统。这些因素使得kshv相关疾病成为免疫治疗方法的首要目标。在kshv相关疾病中,已经研究或正在研究几种药物,包括单克隆抗体、免疫调节剂和治疗性细胞因子。在这里,我们回顾免疫疗法在kshv相关疾病中的作用。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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