Association of allergic disease with Parkinson's disease: A nationally representative retrospective cohort study

IF 6.2 2区 医学 Q1 ALLERGY Allergology International Pub Date : 2024-01-01 DOI:10.1016/j.alit.2023.07.005
Ji Yoon Nam , Sun Jae Park , Jihun Song , Seogsong Jeong , Seulggie Choi , Sang Min Park
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Abstract

Background

The association of allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis with Parkinson's disease (PD) risk is yet unclear. In the few preceding studies, a short follow-up duration was followed for a relatively small study population, and lifestyle behaviors were not adjusted for. Therefore, there is a need for large-scale observation studies on the association of allergic disease with PD risk after considering lifestyle behaviors.

Methods

The study population consisted of 398,936 participants aged 40 years or older who underwent health screening before 1 January 2005 from the Korean National Health Insurance Service database. Starting from 1 January 2005, all participants were followed up until the date of PD event, death, or 31 December 2019. The adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for the risk of PD were calculated using multivariable Cox proportional hazards regression.

Results

Compared to non-allergic disease participants, allergic disease patients had a higher risk for PD (aHR 1.18, 95% CI 1.07–1.30) and especially, allergic rhinitis patients had a higher risk for PD (aHR 1.14, 95% CI 1.00–1.29). Allergic disease was associated with a higher risk for PD (aHR 1.24, 95% CI 1.01–1.52) among participants who were never smokers, did not consume alcohol, and exercised regularly.

Conclusions

Allergic rhinitis was associated with a higher risk for PD compared to participants without allergic rhinitis. This risk-increasing association of allergic rhinitis with PD was preserved even among people with healthy lifestyle behaviors.

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过敏性疾病与帕金森病的关系:一项具有全国代表性的回顾性队列研究
背景过敏性鼻炎、哮喘和特应性皮炎等过敏性疾病与帕金森病(PD)风险的关系尚不清楚。在之前的少数研究中,对相对较少的研究人群进行的随访持续时间较短,且未对生活方式行为进行调整。因此,有必要在考虑生活方式行为后,对过敏性疾病与帕金森病风险的相关性进行大规模的观察研究。方法研究人群包括韩国国民健康保险服务数据库中 2005 年 1 月 1 日前接受健康检查的 398936 名 40 岁及以上的参与者。自 2005 年 1 月 1 日起,对所有参与者进行了随访,直至发生 PD 事件、死亡或 2019 年 12 月 31 日。结果与非过敏性疾病患者相比,过敏性疾病患者罹患帕金森病的风险更高(aHR 1.18,95% CI 1.07-1.30),尤其是过敏性鼻炎患者罹患帕金森病的风险更高(aHR 1.14,95% CI 1.00-1.29)。在从不吸烟、不饮酒和经常锻炼的参与者中,过敏性疾病与更高的帕金森病风险相关(aHR 1.24,95% CI 1.01-1.52)。即使在有健康生活方式行为的人群中,过敏性鼻炎与帕金森病的这种风险升高关系仍然存在。
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来源期刊
Allergology International
Allergology International ALLERGY-IMMUNOLOGY
CiteScore
12.60
自引率
5.90%
发文量
96
审稿时长
29 weeks
期刊介绍: Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.
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