Allergology International最新文献

5-hydroxyeicosatetraenoic acid and 12-hydroxyeicosapentaenoic acid regulate basophil and mast cell activation and basophil recruitment in chronic spontaneous urticaria. 5-羟基二十碳四烯酸和12-羟基二十碳五烯酸调节慢性自发性荨麻疹中嗜碱性细胞和肥大细胞的活化和嗜碱性细胞的募集。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-06 DOI: 10.1016/j.alit.2025.12.005

Mana Ito, Yoshimi Miki, Shota Toyoshima, Maho Tagui, Koremasa Hayama, Hideki Fujita, Yoshitaka Taketomi, Makoto Murakami, Yoshimichi Okayama

Background: The underlying pathomechanisms of wheal reaction enlargement in chronic spontaneous urticaria (CSU) remain largely unclear. We hypothesized that the activation of mast cells (MCs) and recruitment of basophils to locally inflamed skin would be enhanced by lipid mediators (LMs) following initial skin MC activation. This study aimed to identify the LMs responsible for enhancing the aggregation of IgE-mediated MC activation and basophil chemotaxis.

Methods: We enrolled 77 CSU patients and 36 non-atopic control (NC) subjects. Lipid profiling of plasma from these subjects was performed using liquid chromatography-tandem mass spectrometry/mass spectrometry. We compared LMs before and after omalizumab treatment between responders and non-responders.

Results: The concentration of 5-lipoxygenase-mediated LMs was significantly higher in the plasma obtained from patients than in the plasma obtained from NC subjects. The stepwise model demonstrated that 5-hydroxyeicosatetraenoic acid (HETE) (odds ratio, 3.34; 95 % confidence interval, 1.91-5.86; p = 0.0001) was the strongest independent marker of CSU. Here, 5-HETE significantly upregulated IgE-dependent basophil and MC activation. 12-hydroxyeicosapentaenoic acid (HEPE) demonstrated statistically significant correlations between changes in basophil counts and changes in the LM levels before and after omalizumab administration (p = 0.0146). Additionally, 12-HEPE significantly inhibits TNF-α/IFN-β-induced CCL2 mRNA expression in human keratinocytes. Furthermore, 12-HEPE showed a significant increase in concentration after omalizumab treatment in responders (p = 0.0095), but not in non-responders.

Conclusions: In conclusion, 5-HETE and 12-HEPE may regulate IgE-mediated activation of MCs and basophils and recruitment of basophils in the CSU, respectively, suggesting that these LMs may be involved in the enlargement of wheal reactions.

背景：慢性自发性荨麻疹（CSU）的轮状反应扩大的潜在病理机制仍不清楚。我们假设，在初始皮肤肥大细胞激活后，脂质介质（LMs）会增强肥大细胞（MCs）的激活和局部炎症皮肤的嗜碱性粒细胞的募集。本研究旨在确定负责增强ige介导的MC激活和嗜碱性粒细胞趋化性聚集的LMs。方法：我们招募了77例CSU患者和36例非特应性对照组（NC）。使用液相色谱-串联质谱/质谱法对这些受试者的血浆进行脂质谱分析。我们比较了有反应者和无反应者在奥玛珠单抗治疗前后的LMs。结果：患者血浆中5-脂氧合酶介导的LMs浓度明显高于NC组血浆。逐步模型显示，5-羟基二糖四烯酸（HETE）（优势比为3.34；95%可信区间为1.91 ~ 5.86;p = 0.0001）是CSU最强的独立标志物。在这里，5-HETE显著上调ige依赖性嗜碱性粒细胞和MC的激活。12-羟基二碳五烯酸（HEPE）在奥玛珠单抗前后嗜碱性粒细胞计数变化与LM水平变化之间具有统计学意义（p = 0.0146）。此外，12-HEPE显著抑制TNF-α/IFN-β诱导的人角质形成细胞CCL2 mRNA表达。此外，在奥玛珠单抗治疗后，12-HEPE浓度显著增加（p = 0.0095），但在无反应者中没有。结论：综上所述，5-HETE和12-HEPE可能分别调节ige介导的CSU中MCs和嗜碱性细胞的激活和嗜碱性细胞的募集，提示这些LMs可能参与了轮状反应的扩大。

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引用次数: 0

Clinical remission in asthma and related diseases: Current landscape and future perspectives 哮喘及相关疾病的临床缓解：现状和未来展望

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-01 DOI: 10.1016/j.alit.2025.12.002

Hiroyuki Nagase (Associate Editor, Allergology International)

引用次数: 0

IgE reactivity to a walnut gibberellin-regulated protein in a patient with walnut anaphylaxis: A case report 核桃过敏反应患者对核桃赤霉素调节蛋白的IgE反应性：1例报告。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-01 DOI: 10.1016/j.alit.2025.11.002

Yuji Mori , Keiko Momma , Hikaru Sugita , Toya Kono , Nobuaki Okumura , Hiroshi Narita , Yasuto Kondo

引用次数: 0

Uneven distribution of air trapping and its impact on physical activity in patients with asthma 哮喘患者空气捕获分布不均匀及其对身体活动的影响。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-01 DOI: 10.1016/j.alit.2025.06.002

Ayumi Fukatsu-Chikumoto , Tsunahiko Hirano , Hiroshi Iwamoto , Taiga Kobayashi , Yoshie Kunihiro , Keiko Doi , Kazuki Hamada , Yoriyuki Murata , Toshiaki Utsunomiya , Keiji Oishi , Maki Asami-Noyama , Nobutaka Edakuni , Kazuma Kawamoto , Toshihito Otani , Naoko Higaki , Yoshihiro Amano , Mayuka Yamane , Naoya Tanabe , Akihito Yokoyama , Takeshi Isobe , Kazuto Matsunaga

Background

The underlying pathophysiology of varying physical activity levels in patients with asthma remains unclear. In this study, we investigated the association between physical activity and air trapping, identified via chest computed tomography, in patients with asthma.

Methods

The following computed tomography analyses were used to evaluate air trapping in two cohorts (Cohort 1: 27 patients with asthma, 12 healthy individuals; Cohort 2: 90 patients with asthma, 43 healthy individuals): density analysis, focusing on air trapping characteristics during expiration, and parametric response mapping (PRM), which integrates inspiratory and expiratory computed tomography scans to categorize air trapping into small airway disease (PRM^SAD) and low-attenuation areas. Mucus plug scores were also measured.

Results

Patients with asthma exhibited significantly reduced activity levels compared with healthy participants at intensities of ≥2, ≥3, and ≥4 metabolic equivalents (METs) in both cohorts. Among patients with asthma, air trapping was significantly associated with decreased physical activity of ≥4 METs, corresponding to moderate-to-vigorous exercise intensity. Among the air-trapping components, increased PRM^SAD significantly contributed to reduced physical activity at ≥4 METs. Regarding the relationship between PRM^SAD and physical activity for each lung lobe, elevated PRM^SAD in the left upper lobe played a significant role in decreasing physical activity. The presence of mucus plugs was associated with elevated PRM^SAD.

Conclusions

The uneven distribution of air trapping in the lungs of patients with asthma, particularly in the upper lobe, was linked to reduced moderate-to-vigorous-intensity physical activity and was partially attributable to small airway obstruction caused by mucus plugs.

背景：哮喘患者不同体力活动水平的潜在病理生理学尚不清楚。在这项研究中，我们调查了哮喘患者通过胸部计算机断层扫描确定的身体活动与空气捕获之间的关系。方法：采用以下计算机断层扫描分析来评估两个队列的空气捕获(队列1:27例哮喘患者，12例健康个体；队列2:90例哮喘患者，43例健康个体)：密度分析，关注呼气时的空气捕获特征，参数反应映射（PRM），整合吸气和呼气计算机断层扫描，将空气捕获分为小气道疾病（PRMSAD）和低衰减区。还测量了粘液堵塞评分。结果：与健康参与者相比，哮喘患者在≥2、≥3和≥4代谢当量（METs）强度下的活动水平显著降低。在哮喘患者中，空气滞留与≥4 METs的体力活动减少显著相关，对应于中等到剧烈的运动强度。在空气捕获成分中，PRMSAD的增加显著导致≥4 METs时身体活动的减少。关于各肺叶PRMSAD与身体活动的关系，左上肺叶PRMSAD升高对身体活动的降低有显著作用。黏液塞的存在与PRMSAD升高有关。结论：哮喘患者肺部（尤其是上肺叶）空气捕获分布不均匀，与中高强度体力活动减少有关，部分归因于粘液塞引起的小气道阻塞。

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引用次数: 0

Current definition of remission in eosinophilic granulomatosis with polyangiitis (EGPA) and future perspectives 嗜酸性肉芽肿病合并多血管炎（EGPA）缓解的当前定义和未来展望。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-01 DOI: 10.1016/j.alit.2025.10.004

Hiromichi Tamaki

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis for which achieving remission is the primary therapeutic goal. Historically, remission in EGPA was defined by the absence of active vasculitis, typically a Birmingham Vasculitis Activity Score (BVAS) of 0. However, this definition is insufficient as it overlooks the significant morbidity associated with long-term glucocorticoid (GC) therapy. Recent evidence highlights that even low-dose GCs carry substantial risks, challenging the traditional acceptance of remission on GC. This review summarizes the evolution of the remission concept in EGPA, highlighting the paradigm shift seen in recent pivotal clinical trials for biologics, which have incorporated stringent GC dose thresholds (e.g., prednisone ≤4 mg/day) into their primary endpoints. This reflects a growing consensus that minimizing GC exposure is a crucial component of a successful treatment outcome. Further, this review explores potential future components for remission criteria, such as organ-specific activity measures and patient-reported outcomes.

嗜酸性肉芽肿病合并多血管炎（EGPA）是一种罕见的系统性血管炎，实现缓解是主要的治疗目标。从历史上看，EGPA的缓解是通过没有活动性血管炎来定义的，通常是伯明翰血管炎活动评分（BVAS）为0。然而，这一定义是不够的，因为它忽略了与长期糖皮质激素（GC）治疗相关的显著发病率。最近的证据强调，即使是低剂量的胃癌也有很大的风险，挑战了传统上对胃癌缓解的接受。本综述总结了EGPA缓解概念的演变，强调了近期生物制剂关键临床试验中的范式转变，这些试验将严格的GC剂量阈值（例如，泼尼松≤4mg /天）纳入其主要终点。这反映了越来越多的共识，即最小化GC暴露是成功治疗结果的关键组成部分。此外，本综述探讨了缓解标准的潜在未来组成部分，如器官特异性活动测量和患者报告的结果。

引用次数: 0

Unsupervised identification of asthma symptom subtypes supports treatable traits approach 无监督的哮喘症状亚型鉴定支持可治疗特征方法。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-01 DOI: 10.1016/j.alit.2025.06.004

Kazuki Hamada , Takeshi Abe , Keiji Oishi , Yoriyuki Murata , Tsunahiko Hirano , Takahide Hayano , Masahiko Nakatsui , Yoshiyuki Asai , Kazuto Matsunaga

Background

Heterogeneity of asthma requires a personalized therapeutic approach. However, objective measurements, such as spirometry and fraction of exhaled nitric oxide (FeNO) for implementing treatable traits approach, are limited in low- and middle-income countries and non-specialist settings. To implement precision medicine even with minimal resources, we developed an algorithm using unsupervised machine learning techniques that estimates key treatable traits (airflow limitation, type 2 [T2] inflammation, and frequent exacerbations) based on an asthma patient-reported outcome (PRO).

Methods

We applied hierarchical clustering and Uniform Manifold Approximation and Projection (UMAP) to Asthma Control Questionnaire (ACQ)-5 including five residual symptoms from two asthma cohorts (the discovery cohort with 1697 patients and validation cohort with 157 patients).

Results

We identified five symptom clusters, characterized by key treatable traits: Cluster 1, minimal asthma symptoms; Cluster 2, a little symptom, mild airflow limitation; Cluster 3, predominant shortness of breath and wheezes, airflow limitation; Cluster 4, predominant morning symptoms and nocturnal awakening, T2 inflammation; and Cluster 5, all symptoms severe, airflow limitation, T2 inflammation and frequent exacerbations. The UMAP projections of ACQ-5 (five-dimensional) to two-dimensions allowed to visualize datapoints and clusters, which visually revealed that patients with poorly-controlled asthma were divided into Clusters 3, 4 and 5. These results were externally validated in an independent cohort.

Conclusions

Based on asthma PRO data, the developed algorithm categorized asthma patients into five symptom-based subtypes that provide insights into key treatable traits. Our data-driven digital health approach will extend precision medicine of asthma to medical facilities even in resource-constrained settings.

背景：哮喘的异质性需要个性化的治疗方法。然而，用于实施可治疗特征方法的客观测量，如肺量测定法和呼出一氧化氮（FeNO）分数，在中低收入国家和非专业环境中是有限的。为了以最少的资源实现精准医疗，我们开发了一种使用无监督机器学习技术的算法，该算法基于哮喘患者报告的结果（PRO）来估计关键的可治疗特征（气流限制、2型[T2]炎症和频繁恶化）。方法：采用分层聚类和均匀流形逼近投影（UMAP）方法对哮喘控制问卷(ACQ)-5进行分析，其中包括来自两个哮喘队列（发现队列1697例患者和验证队列157例患者）的5种残留症状。结果：我们确定了五个症状集群，其特征是关键的可治疗特征：集群1，最小的哮喘症状；第二组，症状轻微，气流受限轻微；群集3，主要的呼吸短促和喘息，气流受限；第4组，以晨间症状和夜间觉醒为主，T2炎症；第5组，所有症状严重，气流受限，T2炎症和频繁恶化。ACQ-5（五维）到二维的UMAP投影允许可视化数据点和簇，直观地显示控制不良的哮喘患者分为簇3、4和5。这些结果在一个独立的队列中得到了外部验证。结论：基于哮喘PRO数据，开发的算法将哮喘患者分为五种基于症状的亚型，这些亚型提供了对关键可治疗特征的见解。我们的数据驱动的数字健康方法将把哮喘的精准医疗扩展到医疗机构，甚至在资源有限的环境中。

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引用次数: 0

Gut microbiota contributes to the maintenance of sublingually induced regulatory T cells and tolerance in mice 肠道菌群有助于维持舌下诱导的调节性T细胞和小鼠的耐受性。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-01 DOI: 10.1016/j.alit.2025.06.003

Saka Winias , Kanan Bando , Boonnapa Temtanapat , Masato Nakano , Masahiro Saito , Shunji Sugawara , Mitsuko Komatsu , Akiyoshi Hirayama , Shinji Fukuda , Takaaki Abe , Kentaro Mizuta , Masahiro Iikubo , Yukinori Tanaka

Background

Sublingual immunotherapy (SLIT) involves the induction of allergen-specific regulatory T (Treg) cells in the oral mucosa-draining submandibular lymph nodes (LNs). However, their subsequent maintenance remains unclear, including the involvement of the gut microbiota. We aimed to investigate where and how SLIT-induced Treg cells are maintained to ensure tolerance to allergens.

Methods

We used a mouse model of prophylactic SLIT with ovalbumin as the allergen. SLIT-induced tolerance was assessed by suppressing delayed-type hypersensitivity (DTH) responses. The distribution of SLIT-induced Treg cells was determined based on their ability to suppress the DTH response upon adoptive transfer. The involvement of LNs and gut microbiota was assessed by the surgical removal of LNs and antibiotic depletion of the gut microbiota, respectively.

Results

Suppression of DTH by SLIT was impaired by surgical removal of submandibular LNs prior to SLIT. Functional SLIT-induced Treg cells were detected in submandibular LNs and gut-draining mesenteric LNs, however, not in skin-draining LNs or the spleen. Intriguingly, the surgical removal of mesenteric LNs alone after SLIT was sufficient to abolish the suppressive effect of SLIT. Gut microbiota depletion by antibiotic treatment after SLIT also abolished the suppressive effect of SLIT and impaired the maintenance of functional SLIT-induced Treg cells in mesenteric LNs.

Conclusions

Functional SLIT-induced Treg cells were maintained in mesenteric LNs in a gut microbiota-dependent manner. Thus, this study revealed a previously unrecognized role of the gut microbiota in SLIT and provided a rationale for targeting the gut environment to improve the efficacy and prolong the maintenance of SLIT.

背景：舌下免疫治疗（SLIT）涉及在口腔粘膜引流的下颌下淋巴结（LNs）诱导过敏原特异性调节性T （Treg）细胞。然而，它们随后的维持尚不清楚，包括肠道微生物群的参与。我们的目的是研究在哪里以及如何维持裂壁诱导的Treg细胞以确保对过敏原的耐受性。方法：建立以卵清蛋白为过敏原的小鼠实验性实验性SLIT模型。通过抑制延迟型超敏反应（DTH）来评估slit诱导的耐受性。slit诱导的Treg细胞的分布是基于它们在过继转移时抑制DTH反应的能力来确定的。分别通过手术切除LNs和肠道微生物群的抗生素消耗来评估LNs和肠道微生物群的受累情况。结果：在进行SLIT之前，手术切除下颌下LNs会损害SLIT对DTH的抑制。功能性裂壁诱导的Treg细胞在下颌骨和肠引流的肠系膜中检测到，但在皮肤引流的淋巴结和脾脏中未检测到。有趣的是，仅在SLIT后手术切除肠系膜ln就足以消除SLIT的抑制作用。SLIT后抗生素治疗的肠道菌群消耗也消除了SLIT的抑制作用，损害了肠系膜LNs中SLIT诱导的功能性Treg细胞的维持。结论：在肠系膜中，slit诱导的Treg细胞以肠道微生物依赖的方式维持功能。因此，本研究揭示了以前未被认识到的肠道微生物群在SLIT中的作用，并为靶向肠道环境以提高SLIT的疗效和延长其维持时间提供了依据。

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引用次数: 0

National survey on diagnosis and treatment of adult anaphylaxis in Japan: The learning about anaphylaxis in adolescence and adulthood (LANA) survey Part 1 日本成人过敏反应诊断和治疗的全国调查：青少年和成年期过敏反应的学习（LANA）调查第一部分。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-01 DOI: 10.1016/j.alit.2025.07.001

Naoko Inomata , Koremasa Hayama , Shunsuke Takahagi , Atsushi Fukunaga , Koji Masuda , Yuma Sunaga , Motohiro Ebisawa , Norito Katoh

Background

There have been few epidemiological surveys regarding adult anaphylaxis in Japan. The aim of the study is to investigate the current condition in the diagnosis and management of adult anaphylaxis in Japan.

Methods

An observational, descriptive, cross-sectional study was conducted among physicians who belong to the Japanese Society for Cutaneous Immunology and Allergy and the Japanese Allergology Society, via cloud-based software. A 24-item questionnaire focused on the implementation of diagnostics and management of anaphylaxis, especially in adults.

Results

There were 537 departments that treated anaphylaxis, including 243 pediatrics, 156 dermatology, 124 internal medicine, and 14 allergy departments. Of the group, 362 departments treated adult patients with anaphylaxis, with 149 dermatology being the most common, followed by114 internal medicine, 85 pediatrics and 14 allergy departments. Big prefectures such as Tokyo have the most facilities. However, in terms of population ratio, it became clear that there was not necessarily more coverage in large cities. For anaphylaxis due to foods, specific IgE measurements were the most frequently performed at more than 90 % of all four departments, whereas skin tests and challenge tests were performed less than the IgE measurements at 56.9 % and 35.1 %, respectively. As for the reasons for not performing them, a lack of manpower was mostly cited, followed by lack of preparation for anaphylaxis before testing, unfamiliarity with testing methods, and low or no medical fees.

Conclusions

The survey revealed the uneven geographical distribution of medical departments and the chief barriers for implementation of the examination in adult anaphylaxis.

背景：关于日本成人过敏反应的流行病学调查很少。本研究的目的是调查日本成人过敏反应的诊断和管理现状。方法：通过基于云的软件，对日本皮肤免疫与过敏学会和日本过敏学会的医生进行了一项观察性、描述性、横断面研究。一份24项调查问卷侧重于过敏反应的诊断和管理的实施，特别是在成人中。结果：全院共有537个科室处理过敏反应，其中儿科243个，皮肤科156个，内科124个，变态反应科14个。该组有362个科室治疗成人过敏反应，其中最常见的是149个皮肤科，其次是114个内科，85个儿科和14个过敏科。像东京这样的大县拥有最多的设施。然而，就人口比例而言，很明显，大城市的覆盖率不一定更高。对于由食物引起的过敏反应，在所有四个部门中，90%以上的人最常进行特异性IgE测量，而皮肤试验和激发试验的频率低于IgE测量，分别为56.9%和35.1%。至于不进行检查的原因，主要是人力不足，其次是检查前对过敏反应缺乏准备，不熟悉检查方法，以及医疗费用低或没有医疗费用。结论：调查揭示了医学部门地域分布的不均匀性和成人过敏反应检查实施的主要障碍。

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引用次数: 0

ST2+ effector memory helper T cells are responsible for long-term asthma exacerbation leading to female-predominant airway inflammation ST2+效应记忆辅助T细胞是导致女性为主的气道炎症的长期哮喘加重的原因。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-01 DOI: 10.1016/j.alit.2025.08.001

Tomomitsu Miyasaka , Kaori Kawakami , Hiroyuki Tanaka , Fumi Shishido , Kaoru Toshima , Masayuki Seki , Chiaki Masuda-Suzuki , Tomohiro Arikawa , Masashi Sasaki , Naoko Nagano , Hideaki Morita , Kaori Dobashi-Okuyama , Tasuku Kawano , Tomoko Takahashi , Motoaki Takayanagi , Isao Ohno , Yutaka Nakamura

Background

The risk of asthma exacerbation is intrinsic to female patients. Enhanced type 2 immune responses are considered to be associated with sustained increased susceptibility to asthma exacerbation in female patients; however, the mechanisms mediating this relationship remain unclear.

Methods

Using a Dermatophagoides farinae-induced asthma mouse model, asthma-related features were evaluated. We focused on memory T cells and aimed to determine the cell types responsible for female-predominant long-term asthma exacerbations using a functional S1P₁ receptor antagonist and parabiotic mouse model.

Results

Compared to male mice, female mice demonstrated aggravated asthma exacerbation 3 months after allergen re-exposure. Higher levels of Th2 cytokines and IL-33 were observed in the lungs of female mice than in those of male mice. Moreover, enhanced Il33 mRNA synthesis in female mice was attributable to LNGFR ⁺ airway epithelial cells. Increased IL-33 production or the female hormonal environment may have led to increased number of ST2⁺CD4⁺ memory T cells. Both 17β-estradiol and progesterone were associated with the expansion of these cells; however, only 17β-estradiol maintained elevated numbers of ST2⁺CD4⁺ memory T cells over time. The suppressed migration of ST2⁺CD4⁺ circulating memory T cells into the lungs attenuated asthmatic inflammation in female mice to levels comparable to those observed in male mice. In contrast, ST2⁺CD4⁺ tissue-resident memory T cells are attributable asthmatic inflammation in male mice.

Conclusions

Our findings suggest that the contribution of memory T cells to asthmatic inflammation varies depending on sex, and female predominance is attributable to an increased number of ST2⁺CD4⁺ circulating memory T cells.

背景：女性患者哮喘加重的风险是固有的。增强的2型免疫反应被认为与女性患者持续增加的哮喘加重易感性有关；然而，调解这种关系的机制尚不清楚。方法：采用粉螨致哮喘小鼠模型，评价哮喘相关特征。我们专注于记忆T细胞，目的是利用功能性S1P1受体拮抗剂和异种小鼠模型确定导致女性为主的长期哮喘恶化的细胞类型。结果：与雄性小鼠相比，雌性小鼠在再暴露过敏原3个月后哮喘加重。雌性小鼠肺中Th2细胞因子和IL-33的水平高于雄性小鼠。此外，雌性小鼠Il33 mRNA合成的增强可归因于lnfr +气道上皮细胞。IL-33分泌增加或女性激素环境可能导致ST2+CD4+记忆T细胞数量增加。17β-雌二醇和黄体酮均与这些细胞的扩增有关；然而，随着时间的推移，只有17β-雌二醇维持了ST2+CD4+记忆T细胞数量的升高。抑制ST2+CD4+循环记忆T细胞向肺部的迁移将雌性小鼠的哮喘炎症减轻到与雄性小鼠相当的水平。相比之下，ST2+CD4+组织驻留记忆T细胞可归因于雄性小鼠的哮喘炎症。结论：我们的研究结果表明，记忆T细胞对哮喘炎症的贡献因性别而异，女性优势归因于ST2+CD4+循环记忆T细胞数量的增加。

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引用次数: 0

The interaction between the skin microbiome and antimicrobial peptides within the epidermal immune microenvironment: Bridging insights into atopic dermatitis 表皮免疫微环境中皮肤微生物组和抗菌肽之间的相互作用：对特应性皮炎的桥接见解。

IF 6.7 2区医学 Q1 ALLERGY

Allergology International

Pub Date : 2026-01-01 DOI: 10.1016/j.alit.2025.08.002

Shan Wang , Ge Peng , Alafate Abudouwanli , Mengyao Yang , Quan Sun , Wanchen Zhao , Arisa Ikeda , Yi Tan , Lin Ma , Hideoki Ogawa , Ko Okumura , François Niyonsaba

The epidermal immune microenvironment is a multifaceted system in which the interplay between the skin microbiome and antimicrobial peptides plays a pivotal role in sustaining skin homeostasis and preventing dysbiosis. Disruption of these interactions can lead to inflammatory skin conditions such as atopic dermatitis. This review aims to explore the complex mechanisms by which antimicrobial peptides and the skin microbiome communicate within the epidermal immune microenvironment, emphasizing causal dynamics and the dual role of antimicrobial peptides. This analysis opens new avenues for targeted interventions, including antimicrobial peptide modulation and microbiome-based therapies, to restore skin health and mitigate inflammatory skin disorders.

表皮免疫微环境是一个多方面的系统，其中皮肤微生物群和抗菌肽之间的相互作用在维持皮肤稳态和防止生态失调中起着关键作用。这些相互作用的破坏可导致炎症性皮肤状况，如特应性皮炎。本文旨在探讨抗菌肽和皮肤微生物群在表皮免疫微环境中相互作用的复杂机制，强调抗菌肽的因果动力学和双重作用。这一分析为有针对性的干预开辟了新的途径，包括抗菌肽调节和基于微生物组的治疗，以恢复皮肤健康和减轻炎症性皮肤疾病。

引用次数: 0