Corynebacterium ramonii sp. nov., a novel toxigenic member of the Corynebacterium diphtheriae species complex

IF 2.5 4区生物学 Q3 MICROBIOLOGY Research in microbiology Pub Date : 2023-09-01 DOI:10.1016/j.resmic.2023.104113

Chiara Crestani , Gabriele Arcari , Annie Landier , Virginie Passet , Dorian Garnier , Sylvie Brémont , Nathalie Armatys , Annick Carmi-Leroy , Julie Toubiana , Edgar Badell , Sylvain Brisse

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引用次数: 1

Abstract

The Corynebacterium diphtheriae species complex comprises seven bacterial species, including Corynebacterium ulcerans, a zoonotic pathogen from multiple animal species. In this work, we characterise phenotypically and genotypically isolates belonging to two C. ulcerans lineages. Results from phylogenetic analyses, in silico DNA–DNA hybridization (DDH) and MALDI-TOF spectra differentiate lineage 2 from C. ulcerans lineage 1, which, together with their distinct transmission dynamics (probable human-to-human vs animal-to-human), indicates that lineage 2 is a separate Corynebacterium species, which we propose to name Corynebacterium ramonii. This species is of particular medical interest considering that its human-to-human transmission is likely, and that some C. ramonii isolates carry the diphtheria toxin gene.

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雷莫尼棒状杆菌（Corynebacterium ramonii sp.nov.），白喉棒状杆菌物种复合体的一个新的产毒成员。

白喉棒状杆菌物种复合体包括七种细菌，包括溃疡棒状杆菌，一种来自多种动物的人畜共患病原体。在这项工作中，我们对属于两个溃疡梭菌谱系的表型和基因型分离株进行了表征。系统发育分析的结果，计算机DNA-DNA杂交（DDH）和MALDI-TOF光谱将谱系2与溃疡杆菌谱系1区分开来，再加上它们不同的传播动力学（可能是人与人与动物与人之间），表明谱系2是一个独立的棒状杆菌物种，我们建议将其命名为雷蒙氏棒状杆菌。考虑到该物种很可能在人与人之间传播，并且一些分枝杆菌分离株携带白喉毒素基因，该物种具有特别的医学意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in microbiology 生物-微生物学

CiteScore

4.10

自引率

3.80%

发文量

审稿时长

16 days

期刊介绍： Research in Microbiology is the direct descendant of the original Pasteur periodical entitled Annales de l''Institut Pasteur, created in 1887 by Emile Duclaux under the patronage of Louis Pasteur. The Editorial Committee included Chamberland, Grancher, Nocard, Roux and Straus, and the first issue began with Louis Pasteur''s "Lettre sur la Rage" which clearly defines the spirit of the journal:"You have informed me, my dear Duclaux, that you intend to start a monthly collection of articles entitled "Annales de l''Institut Pasteur". You will be rendering a service that will be appreciated by the ever increasing number of young scientists who are attracted to microbiological studies. In your Annales, our laboratory research will of course occupy a central position, but the work from outside groups that you intend to publish will be a source of competitive stimulation for all of us."That first volume included 53 articles as well as critical reviews and book reviews. From that time on, the Annales appeared regularly every month, without interruption, even during the two world wars. Although the journal has undergone many changes over the past 100 years (in the title, the format, the language) reflecting the evolution in scientific publishing, it has consistently maintained the Pasteur tradition by publishing original reports on all aspects of microbiology.

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