Role of the viral polymerase during adaptation of influenza A viruses to new hosts

IF 5.7 2区 医学 Q1 VIROLOGY Current opinion in virology Pub Date : 2023-10-01 DOI:10.1016/j.coviro.2023.101363
Brad Gilbertson , Melanie Duncan , Kanta Subbarao
{"title":"Role of the viral polymerase during adaptation of influenza A viruses to new hosts","authors":"Brad Gilbertson ,&nbsp;Melanie Duncan ,&nbsp;Kanta Subbarao","doi":"10.1016/j.coviro.2023.101363","DOIUrl":null,"url":null,"abstract":"<div><p>As a group, influenza-A viruses (IAV) infect a wide range of animal hosts, however, they are constrained to infecting selected host species by species-specific interactions between the host and virus, that are required for efficient replication of the viral RNA genome. When IAV cross the species barrier, they acquire mutations in the viral genome to enable interactions with the new host factors, or to compensate for their loss. The viral polymerase genes polymerase basic 1, polymerase basic 2, and polymerase-acidic are important sites of host adaptation. In this review, we discuss why the viral polymerase is so vital to the process of host adaptation, look at some of the known viral mutations, and host factors involved in adaptation, particularly of avian IAV to mammalian hosts.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"62 ","pages":"Article 101363"},"PeriodicalIF":5.7000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in virology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1879625723000639","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

As a group, influenza-A viruses (IAV) infect a wide range of animal hosts, however, they are constrained to infecting selected host species by species-specific interactions between the host and virus, that are required for efficient replication of the viral RNA genome. When IAV cross the species barrier, they acquire mutations in the viral genome to enable interactions with the new host factors, or to compensate for their loss. The viral polymerase genes polymerase basic 1, polymerase basic 2, and polymerase-acidic are important sites of host adaptation. In this review, we discuss why the viral polymerase is so vital to the process of host adaptation, look at some of the known viral mutations, and host factors involved in adaptation, particularly of avian IAV to mammalian hosts.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
病毒聚合酶在甲型流感病毒适应新宿主过程中的作用
作为一个群体,甲型流感病毒(IAV)感染广泛的动物宿主,然而,宿主和病毒之间的物种特异性相互作用限制了它们感染选定的宿主物种,这是病毒RNA基因组有效复制所必需的。当IAV跨越物种屏障时,它们会在病毒基因组中获得突变,从而能够与新的宿主因子相互作用,或补偿它们的损失。病毒聚合酶基因聚合酶碱性1、聚合酶碱性2和聚合酶酸性是宿主适应的重要位点。在这篇综述中,我们讨论了为什么病毒聚合酶对宿主适应过程如此重要,研究了一些已知的病毒突变,以及参与适应的宿主因素,特别是鸟类IAV对哺乳动物宿主的适应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
期刊最新文献
Host-pathogen interactions of emerging zoonotic viruses: bats, humans and filoviruses. Blood virome research in myalgic encephalomyelitis/chronic fatigue syndrome: challenges and opportunities. Advancing zoonotic respiratory virus research through the use of organoids. Editorial Board Koala retrovirus and neoplasia: correlation and underlying mechanisms
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1