Changes in insulin resistance, glucose effectiveness, and first and second phases of insulin secretion in women aged 45-60 years old in Taiwan.

IF 1.9 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Journal of the Chinese Medical Association Pub Date : 2023-10-01 Epub Date: 2023-08-10 DOI:10.1097/JCMA.0000000000000976
Chen-Yu Wang, Chung-Ze Wu, Fang-Yu Chen, Dee Pei, Li-Ying Huang
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引用次数: 2

Abstract

Background: In women after menopause, the incidence of diabetes mellitus increases. Increased insulin resistance (IR), decreased glucose effectiveness (GE), and the first and second phases of insulin secretion (FPIS and SPIS), are the four most important factors that trigger glucose intolerance and diabetes (diabetogenic factor [DF]). In the cross-sectional study, we enrolled nondiabetic women between the ages of 45 and 60 years to observe the changes in DFs during the perimenopausal period and to elucidate the underlying mechanisms of diabetes in menopausal women.

Methods: We randomly enrolled 4194 women who underwent health checkups. Using demographic and biochemical data, IR, FPIS, SPIS, and GE were calculated using previously published equations. The relationship between the DFs and age was evaluated using a simple correlation.

Results: Body mass index, blood pressure, fasting plasma glucose, low-density lipoprotein cholesterol, triglyceride, and SPIS were higher, and GE was lower in older women (≥52 years old). A significant decrease in GE and increased SPIS were observed with age. However, no changes were observed in IR or FPIS.

Conclusion: The IR and FPIS did not change during perimenopause. Increased SPIS may compensate for the decrease in GE, which is probably one of the reasons for the higher incidence of diabetes in menopausal women.

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台湾45-60岁女性胰岛素抵抗、血糖有效性和胰岛素分泌第一和第二阶段的变化。
背景:在绝经后的女性中,糖尿病的发病率增加。胰岛素抵抗(IR)增加、葡萄糖有效性(GE)降低以及胰岛素分泌的第一和第二阶段(FPIS和SPIS)是引发葡萄糖不耐受和糖尿病的四个最重要因素(糖尿病因子[DF])。在横断面研究中,我们招募了年龄在45岁至60岁之间的非糖尿病女性,以观察围绝经期DFs的变化,并阐明更年期女性糖尿病的潜在机制。方法:我们随机招募了4194名接受健康检查的女性。使用人口统计学和生物化学数据,使用先前发表的方程计算IR、FPIS、SPIS和GE。DFs和年龄之间的关系使用简单的相关性进行评估。结果:老年妇女(≥52岁)的体重指数、血压、空腹血糖、低密度脂蛋白胆固醇、甘油三酯和SPIS较高,GE较低。随着年龄的增长,GE显著降低,SPIS增加。然而,在IR或FPIS中没有观察到变化。结论:围绝经期IR和FPIS无明显变化。SPIS的增加可以弥补GE的减少,这可能是更年期女性糖尿病发病率较高的原因之一。
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来源期刊
Journal of the Chinese Medical Association
Journal of the Chinese Medical Association MEDICINE, GENERAL & INTERNAL-
CiteScore
6.20
自引率
13.30%
发文量
320
审稿时长
15.5 weeks
期刊介绍: Journal of the Chinese Medical Association, previously known as the Chinese Medical Journal (Taipei), has a long history of publishing scientific papers and has continuously made substantial contribution in the understanding and progress of a broad range of biomedical sciences. It is published monthly by Wolters Kluwer Health and indexed in Science Citation Index Expanded (SCIE), MEDLINE®, Index Medicus, EMBASE, CAB Abstracts, Sociedad Iberoamericana de Informacion Cientifica (SIIC) Data Bases, ScienceDirect, Scopus and Global Health. JCMA is the official and open access journal of the Chinese Medical Association, Taipei, Taiwan, Republic of China and is an international forum for scholarly reports in medicine, surgery, dentistry and basic research in biomedical science. As a vehicle of communication and education among physicians and scientists, the journal is open to the use of diverse methodological approaches. Reports of professional practice will need to demonstrate academic robustness and scientific rigor. Outstanding scholars are invited to give their update reviews on the perspectives of the evidence-based science in the related research field. Article types accepted include review articles, original articles, case reports, brief communications and letters to the editor
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