One-step preparation of double emulsions stabilized with amphiphilic and stimuli-responsive block copolymers and nanoparticles for nutraceuticals and drug delivery

Q3 Materials Science JCIS open Pub Date : 2021-10-01 DOI:10.1016/j.jciso.2021.100020

Shima Saffarionpour

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引用次数: 3

Abstract

One-step emulsification approaches enable prevention of the loss of emulsion droplets associated with two-step emulsification approaches. Stimuli-responsive amphiphilic block copolymers, emulsifiers, and nanoparticles that are responsive to changes in the temperature, pH, presence of CO₂, or presence of salts, can eliminate the requirement for two hydrophilic and lipophilic emulsifiers in the emulsion system. The amphiphilic block copolymers prepared from naturally occurring amino acids and proteins enable targeted delivery of drugs and nutraceuticals with high cellular uptake. Likewise, the presence of impurities, such as salts and redox reactions driven by the presence of iodine, can result in spontaneous emulsification and formation of double emulsions. This timely review focuses on the application of double emulsions for delivery of drugs and nutraceuticals and will provide insights to scientists in the pharmaceutical industry or food nutritionists who consider fortification of food products with micronutrients.

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一步制备两亲性和刺激响应嵌段共聚物和纳米颗粒稳定的双乳液，用于营养药品和药物输送

一步乳化方法可以防止与两步乳化方法相关的乳液液滴损失。刺激响应的两亲性嵌段共聚物、乳化剂和纳米颗粒对温度、pH值、CO2或盐的存在都有响应，可以消除乳液体系中对两种亲水性和亲脂性乳化剂的需求。由天然存在的氨基酸和蛋白质制备的两亲性嵌段共聚物能够靶向递送具有高细胞摄取的药物和营养保健品。同样，杂质的存在，如盐和由碘的存在驱动的氧化还原反应，可以导致自发乳化和形成双乳。这篇及时的综述着重于双乳剂在药物和营养品输送中的应用，并将为制药行业的科学家或考虑用微量营养素强化食品的食品营养学家提供见解。

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