JCIS open最新文献

Historical perspective in technological advances in lithium-ion battery development 锂离子电池发展技术进步的历史展望

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2025-11-21 DOI: 10.1016/j.jciso.2025.100163

Rajasekar Krishnan , Vinitha Packirisamy , Deva Palani , Rajabhuvaneswari Ariyamuthu

The commercial world has made significant progress in lithium-based battery technology over the past three decades. The history of lithium-based batteries spans a lengthy timeline of substantial innovations and setbacks, beginning with the first lithium-metal anodes and continuing to the current generation of commercial lithium-ion batteries (LIBs). This review records the historical evolution of lithium-based batteries, from early lithium-metal prototypes hindered by dendrite formation and safety concerns to the commercialization of LIBs in 1991. We will also investigate the significant contribution that material science has made to the development of LIBs. Due to advances in LIB research and the numerous materials under investigation, several subfields of materials science have attracted varying degrees of research focus. Initial research into lithium-ion batteries (LIBs) mainly concentrated on solid-state physics as the primary area of interest. However, in the latter half of the 20th century, researchers focused on studying the morphological features of electrode materials. These properties included surface coating, porosity, size, and form. That helps identify the specific anode and cathode materials that will be compatible with future generations of batteries. To provide a comprehensive picture of LIB's development over history, this analysis will also offer an in-depth explanation of the circumstances that have driven the numerous technological advances.

在过去的三十年里，商业世界在锂基电池技术方面取得了重大进展。锂基电池的历史跨越了一个漫长的创新和挫折的时间表，从第一个锂金属阳极开始，一直到当前一代的商用锂离子电池（lib）。这篇综述记录了锂基电池的历史演变，从早期的锂金属原型受到枝晶形成和安全问题的阻碍，到1991年锂基电池的商业化。我们还将研究材料科学对lib发展的重大贡献。由于LIB研究的进展和众多正在研究的材料，材料科学的几个子领域吸引了不同程度的研究重点。对锂离子电池（LIBs）的初步研究主要集中在固态物理领域。然而，在20世纪下半叶，研究人员主要集中在研究电极材料的形态特征。这些特性包括表面涂层、孔隙度、尺寸和形状。这有助于确定与未来几代电池兼容的特定阳极和阴极材料。为了提供LIB在历史上发展的全面图景，本分析还将提供对推动众多技术进步的环境的深入解释。

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引用次数: 0

Permeation mechanism of gas molecules through polyimide barrier coatings with freeze- and oven-dried modified layered silicates 气体分子通过冷冻和烘干改性层状硅酸盐聚酰亚胺屏障涂层的渗透机理

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2025-11-19 DOI: 10.1016/j.jciso.2025.100162

Joshua Lommes , Volkmar Stenzel , Andreas Hartwig

One effective strategy to improve the barrier performance of polymeric coating layers is the incorporation of layered silicate particles. This study investigates how the drying technology of silicates—specifically freeze-drying versus oven-drying—affects the permeation properties of the coatings. Modified layered silicates, prepared using both drying methods, are incorporated in varying amounts into polyimide coatings. The arrangement, orientation, and exfoliation of the particles are analysed using SEM. Results indicate that a higher proportion of layered silicates enhances the tortuosity of the diffusion pathway, thereby reducing permeability. Furthermore, permeation measurements of oxygen and water vapor, along with the calculated activation energies, reveal distinct differences in the permeation mechanisms of these gases through the coating films, highlighting the significant impact of the drying method on the barrier properties of the coatings.

提高聚合物涂层阻隔性能的一种有效策略是加入层状硅酸盐颗粒。本研究探讨了硅酸盐的干燥技术-特别是冷冻干燥和烘箱干燥-如何影响涂层的渗透性能。使用两种干燥方法制备的改性层状硅酸盐以不同的量掺入聚酰亚胺涂层中。用扫描电镜分析了颗粒的排列、取向和脱落情况。结果表明，层状硅酸盐含量的增加增加了扩散路径的弯曲度，从而降低了渗透率。此外，氧气和水蒸气的渗透测量，以及计算的活化能，揭示了这些气体通过涂层的渗透机制的明显差异，突出了干燥方法对涂层阻隔性能的显著影响。

引用次数: 0

Why critical drying, not hydrogen bonding, governs hydrophobic attraction between extended solutes 为什么是临界干燥，而不是氢键，决定了扩展溶质之间的疏水吸引力

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2026-01-20 DOI: 10.1016/j.jciso.2026.100170

Nigel B. Wilding, Francesco Turci

引用次数: 0

Key features enabling water repellency in velvet worm skin: Overhanging scales and carbonate-wax synergy 主要特点使防水在天鹅绒蠕虫皮肤：悬垂鳞片和碳酸盐蜡协同作用

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2025-12-11 DOI: 10.1016/j.jciso.2025.100165

Yendry Regina Corrales Ureña , Ingo Lieberwirth , Paul-Ludwig Michael Noeske , Frandy Arroyo Vargas , Diego Batista Menezes , Reinaldo Pereira-Reyes , José Roberto Vega-Baudrit

Nature has evolved sophisticated surface architectures to achieve non-wettability and self-cleaning performance under challenging environmental conditions. In this study, we elucidate the multiscale chemical and structural mechanisms underlying the exceptional water-repellent and anti-adhesive properties of the velvet worm Epiperipatus biolleyi. By integrating cryo-scanning electron microscopy (cryo-SEM), transmission electron microscopy (TEM), confocal Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) depth profiling, X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS), and contact angle measurements, we reveal a synergistic system composed of hierarchical micropapillae bearing overhanging tiptop scales and surrounded by nanowrinkles. We further show that the cuticle is biomineralized with calcium–magnesium carbonate phases beneath a waxy organic layer. This multiscale architecture yields water contact angles exceeding 130° and sustains a persistent, plastron-like gas layer upon immersion. The presence of overhanging scales with re-entrant curvature (ψ ≈ 34°), together with the surrounding nanowrinkles, inhibits wetting even under pressures higher than atmospheric pressure, as supported by COMSOL Multiphysics 2D simulations. The waxy layers that coat the micro- and nanostructures—composed primarily of long-chain fatty acid amides and fatty acids—further enhance the anti-adhesive behavior. This study also provides the first evidence in Onychophora of extensive cuticular biomineralization, where carbonate dissolution can locally liberate CO₂, contributing to the formation and maintenance of a protective gas plastron around the microstructures. Together, these findings demonstrate that the integration of hierarchical micro- and nanostructures, a biomineralized cuticle, and a biochemical surface coating is essential to the unique anti-adhesive properties of E. biolleyi, underscoring its potential as a model for designing biomimetic, low-adhesion surface technologies.

大自然已经进化出复杂的表面结构，以在具有挑战性的环境条件下实现非润湿性和自清洁性能。在这项研究中，我们阐明了多尺度的化学和结构机制的特殊防水和抗粘性能的天鹅绒蠕虫的生物。通过低温扫描电镜（cryo-SEM）、透射电镜（TEM）、共聚焦拉曼光谱（共聚焦拉曼光谱）、x射线光电子能谱（XPS）深度剖面、x射线衍射（XRD）、能量色散x射线能谱（EDS）和接触角测量，我们揭示了一个由分层微乳头组成的协同系统，这些微乳头具有悬垂的顶部鳞片，并被纳米皱纹包围。我们进一步表明，角质层在蜡质有机层下与碳酸钙-镁相生物矿化。这种多尺度的建筑产生超过130°的水接触角，并在浸入时保持持久的，类似板状的气体层。COMSOL Multiphysics 2D模拟结果表明，具有可重入曲率（ψ≈34°）的悬垂尺度，以及周围的纳米皱纹，即使在高于大气压的压力下也能抑制润湿。涂在微纳米结构上的蜡层——主要由长链脂肪酸酰胺和脂肪酸组成——进一步增强了抗粘接性能。该研究还首次提供了马蹄龙广泛的角质层生物矿化的证据，其中碳酸盐溶解可以局部释放CO2，有助于在微观结构周围形成和维持保护性气体板。总之，这些发现表明，层次化微纳米结构、生物矿化角质层和生物化学表面涂层的整合对于生物胶的独特抗粘附性能至关重要，强调了其作为设计仿生低粘附表面技术的模型的潜力。

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引用次数: 0

Surface modification of polyurethane biomaterials by ammonia plasma: bacterial adhesion and cellular response 氨等离子体对聚氨酯生物材料表面的改性：细菌粘附和细胞反应

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2026-02-13 DOI: 10.1016/j.jciso.2026.100173

Kamil Drożdż , Paulina Chytrosz-Wróbel , Divya Kumar , Andrzej Kotarba , Monika Brzychczy-Włoch

Polyurethanes (PUs) are versatile polymers widely used in biomedical applications due to their tunable properties. However, PU-based medical devices are susceptible to bacterial contamination, necessitating surface modifications to improve biocompatibility and reduce colonization. This study introduced amine groups (–NH₂) onto PU surfaces using low-temperature ammonia plasma and evaluated effects on bacterial adhesion and biocompatibility. X-ray photoelectron spectroscopy (XPS), contact angle measurements, atomic force microscopy (AFM), fluorescence microscopy, and biocompatibility assays were employed. Ammonia plasma effectively introduced amine groups, confirmed by XPS. The contact angle decreased markedly (from 101.5° to 36.3°), accompanied by a pronounced increase in surface free energy (from 27.3 to 64.6 mJ/m²), indicating enhanced hydrophilicity, while AFM analysis revealed no significant changes in surface roughness (RMS). Bacterial adhesion increased for P. aeruginosa DSM 22644, S. aureus DSM 4910, and S. epidermidis DSM 28319, but was unaffected for E. coli DSM 18039. Biocompatibility tests with A549 cells showed improved adhesion, morphology, and cytoskeletal organization, with elevated focal adhesion kinase (FAK) expression. Ammonia plasma thus enhances PU biocompatibility while influencing bacterial adhesion.

聚氨酯（pu）是一种多用途聚合物，由于其可调节的特性而广泛用于生物医学应用。然而，基于pu的医疗器械容易受到细菌污染，因此需要进行表面修饰以提高生物相容性并减少定植。本研究利用低温氨血浆将氨基（-NH2）引入PU表面，并评价其对细菌粘附和生物相容性的影响。采用x射线光电子能谱（XPS）、接触角测量、原子力显微镜（AFM）、荧光显微镜和生物相容性测定。氨气血浆有效引入胺基，经XPS证实。接触角明显减小（从101.5°到36.3°），表面自由能明显增加（从27.3到64.6 mJ/m2），表明亲水性增强，而AFM分析显示表面粗糙度（RMS）没有显著变化。铜绿假单胞菌DSM 22644、金黄色葡萄球菌DSM 4910和表皮葡萄球菌DSM 28319的细菌粘附性增加，而大肠杆菌DSM 18039的细菌粘附性不受影响。A549细胞的生物相容性测试显示，细胞黏附性、形态学和细胞骨架组织得到改善，局灶黏附激酶（FAK）表达升高。氨水血浆因此增强PU的生物相容性，同时影响细菌粘附。

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引用次数: 0

Physicochemical investigation of DL-DOPA interaction with cationic surfactants: Micellization, binding thermodynamics, and solubilization DL-DOPA与阳离子表面活性剂相互作用的物理化学研究：胶束作用、结合热力学和增溶作用

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jciso.2026.100171

El Mahdi Elkaseh , Haytham Abuissa , Eman Fadhil , Ashraf EL-Hashani

Understanding the interaction between therapeutic agents and surfactant-based drug delivery systems is crucial for designing effective pharmaceutical formulations. This study provides a comprehensive comparative analysis of the physicochemical interactions between the anti-parkinsonian drug DL-DOPA (DOPA) and two cationic surfactants, cetylpyridinium chloride (CPC) and benzalkonium chloride (BKC), in aqueous media. The investigation was conducted using a suite of analytical techniques, including surface tensiometry, conductometry, and UV-Vis spectrophotometry at 25 °C. The results reveal a potent synergistic interaction between DOPA and both surfactants, evidenced by a remarkable depression in the critical micelle concentration (CMC): a 70% reduction was observed for BKC, while a dramatic 98% reduction was recorded for CPC, highlighting the superior efficiency of the latter in forming mixed micelles with DOPA. Thermodynamic analysis revealed that micellization and drug-micelle binding are spontaneous processes (ΔG < 0). DOPA exhibited a significantly stronger interaction with CPC micelles compared to BKC, as evidenced by a higher binding constant (K_b = 12.64 × 10⁴ L/mol for CPC versus 3.14 × 10⁴ L/mol for BKC) and a more favorable partition coefficient (K_x = 27.82 × 10⁴ L/mol for CPC versus 6.7 × 10⁴L/mol for BKC). This enhanced interaction with CPC is attributed to a combination of hydrophobic forces and potential π-π stacking between the pyridinium head group and the aromatic ring of DOPA. The findings demonstrate that both CPC and BKC can effectively interact with and solubilize DOPA, but CPC offers a more favorable binding and partitioning environment. This detailed characterization provides fundamental insights that can guide the rational selection of cationic surfactants for the development of advanced DOPA delivery systems.

了解治疗剂和基于表面活性剂的药物传递系统之间的相互作用对于设计有效的药物配方至关重要。本研究全面比较分析了抗帕金森药物DL-DOPA （DOPA）与两种阳离子表面活性剂十六烷基吡啶氯（CPC）和苯扎氯铵（BKC）在水介质中的物理化学相互作用。研究使用了一套分析技术，包括表面张力测定法、电导法和紫外可见分光光度法，在25°C下进行。结果表明，DOPA与两种表面活性剂之间存在有效的协同作用，显著降低了临界胶束浓度（CMC）： BKC的临界胶束浓度降低了70%，而CPC的临界胶束浓度降低了98%，这表明后者与DOPA形成混合胶束的效率更高。热力学分析表明胶束化和药物胶束结合是自发过程（ΔG < 0）。与BKC相比，DOPA与CPC胶束的相互作用更强，其结合常数更高（CPC为12.64 × 104L/mol， BKC为3.14 × 104L/mol），分配系数更高（CPC为27.82 × 104L/mol， BKC为6.7 × 104L/mol）。这种与CPC的增强相互作用归因于疏水力和吡啶头基团与DOPA芳香环之间潜在的π-π堆积的结合。结果表明，CPC和BKC均能有效地与DOPA相互作用和溶解，但CPC提供了更有利的结合和分解环境。这种详细的表征提供了基本的见解，可以指导合理选择阳离子表面活性剂，以开发先进的DOPA递送系统。

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引用次数: 0

Bio-printed cellulose nanocrystal: Processing, fabrication, and biomedical applications 生物打印纤维素纳米晶体：加工、制造和生物医学应用

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2026-02-10 DOI: 10.1016/j.jciso.2026.100172

Deepak Kumar , Md Azhar , Sathvik Belagodu Sridhar , Javedh Shareef , Tarun Wadhwa , Rishabha Malviya

Background

Cellulose nanocrystals (CNCs) are sustainable high-strength nanomaterials for cutting-edge biomedical 3D bioprinting and implantable devices.

Aim

This review summarizes the aspects of CNC synthesis, printing strategies, biomedical applications, challenges, and prospects.

Method

The review was carried out from the literature search of Scopus/Web of Science using keywords cellulose nanocrystals (CNC), 3D bioprinting, bioink, rheology, alignment, and hydrogel (2018-2025).

Discussion on novelty

This review condenses the mechanistic understanding of relationships between the CNC surface chemistry, aspect ratio of particulate, and flow-induced alignment of particles and their connection to bioink printability rheology and anisotropic biofunctionality. These highlights innovations targeting the methacrylation, TEMPO-mediated carboxylation, and hybrid processing, which will enable the covalent crosslinking, tunable degradation, and enhanced thermal stability. New contributions are suggestions for accessible concentration windows for printability in CNC applications; definition of the alignment thresholds in conditions of nozzle sheathing; and proposals for cohesive and standard reporting of rheological data. This also finds a gap in translational aspects of sterilization compatibility, batch reproducibility, and in vivo degradation studies that need prioritization of research and regulatory validation pathways.

Conclusion

CNC-based 3D bioprinting provides a sustainable and versatile platform for creating mechanically tough, shear-responsive, and anisotropic biomedical constructs. With the recent breakthroughs in surface modification, alignment control, and the use of hybrid bioinks, there is great potential for employing CNC-enabled systems in applications that require personalized medicine, controlled drug delivery, and next-generation tissue engineering applications.

纤维素纳米晶体（cnc）是用于尖端生物医学3D生物打印和植入式设备的可持续高强度纳米材料。目的综述了CNC合成、打印策略、生物医学应用、面临的挑战和前景。方法通过检索Scopus/Web of Science中纤维素纳米晶体（CNC）、3D生物打印、生物墨水、流变学、取向学和水凝胶（2018-2025）的相关文献进行综述。本文综述了CNC表面化学、颗粒长宽比和颗粒流动诱导排列之间关系的机理理解，以及它们与生物墨水可打印性、流变性和各向异性生物功能的联系。这些突出了针对甲基丙烯酸基化，tempo介导的羧化和混合处理的创新，这将使共价交联，可调降解和增强热稳定性成为可能。新的贡献是CNC应用中可访问的可打印性集中窗口的建议；喷嘴护套条件下对准阈值的定义并对流变数据的统一和规范报告提出了建议。这也发现了灭菌兼容性、批量可重复性和体内降解研究的翻译方面的差距，这些研究和监管验证途径需要优先考虑。结论基于cnc的生物3D打印技术为构建具有机械韧性、剪切响应性和各向异性的生物医学结构提供了一个可持续的、通用的平台。随着最近在表面修饰、对准控制和混合生物墨水使用方面的突破，在需要个性化医疗、控制药物输送和下一代组织工程应用的应用中，采用cnc支持的系统具有巨大的潜力。

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引用次数: 0

Biosurfactants for enhanced oil recovery and bioremediation in the modern petroleum industry: A global review 现代石油工业中用于提高石油采收率和生物修复的生物表面活性剂：全球综述

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2025-12-23 DOI: 10.1016/j.jciso.2025.100168

Mehmet Melikoglu

Biosurfactants, microbial-derived surface-active molecules, present a sustainable and effective alternative to synthetic chemicals in the petroleum industry. This review examines their multifaceted roles in enhanced oil recovery (EOR) and bioremediation of environments contaminated by crude oil and its refined fractions. In EOR, biosurfactants significantly reduce interfacial tension and alter wettability, enhancing oil mobilization as demonstrated by laboratory-scale core flooding (e.g., 31–44 % additional oil recovery) and micromodel studies. Their integration with nanoparticles and polymers further boosts recovery efficiency, with peak performance reaching up to 95.1 % oil recovery. For bioremediation, biosurfactants increase hydrocarbon bioavailability, accelerating the degradation of various petroleum compounds in soil and water. Research shows impressive biodegradation rates, with some consortia achieving over 95 % crude oil degradation, resulting in a reliable mean degradation/removal rate of 92.3 % across reported studies analyzed in this study. Production advancements focus on cost-effective, sustainable feedstocks like agricultural and industrial wastes, optimizing fermentation processes, and developing efficient downstream recovery methods. Detailed characterization efforts, supported by advanced analytical and computational tools (e.g., molecular dynamics simulations), are deepening the understanding of biosurfactant properties, stability under harsh conditions, and precise mechanisms of action. Despite significant progress, future research must address scaling up production for industrial application, validating performance in complex, real-world reservoir and environmental settings, and thoroughly elucidating molecular-level structure-function relationships for rational design. Integrating biosurfactant technology into holistic, circular economy models for pollution management represents a crucial step towards a more sustainable petroleum sector.

生物表面活性剂是一种微生物衍生的表面活性分子，是石油工业中合成化学品的一种可持续和有效的替代品。本文综述了它们在提高原油采收率（EOR）和原油及其精炼馏分污染环境的生物修复中的多方面作用。在提高采收率中，生物表面活性剂可以显著降低界面张力，改变润湿性，增强油的动员，实验规模的岩心驱油（例如，额外采收率为31 - 44%）和微观模型研究证明了这一点。它们与纳米颗粒和聚合物的结合进一步提高了采收率，最高采收率可达95.1%。对于生物修复，生物表面活性剂增加了碳氢化合物的生物利用度，加速了土壤和水中各种石油化合物的降解。研究显示了令人印象深刻的生物降解率，一些联合体实现了95%以上的原油降解，在本研究分析的报告研究中，平均降解/去除率达到了92.3%。生产进步集中在具有成本效益，可持续的原料，如农业和工业废物，优化发酵过程，并开发有效的下游回收方法。在先进的分析和计算工具（如分子动力学模拟）的支持下，详细的表征工作正在加深对生物表面活性剂性质、恶劣条件下的稳定性和精确作用机制的理解。尽管取得了重大进展，但未来的研究必须解决工业应用的规模化生产问题，验证复杂油藏和环境条件下的性能，并彻底阐明分子水平的结构-功能关系，以便进行合理设计。将生物表面活性剂技术整合到污染管理的整体循环经济模型中，是朝着更可持续的石油行业迈出的关键一步。

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引用次数: 0

Wettability based separation of ionomer-containing ultrafine particles for PEM water electrolyzer recycling 基于润湿性的含离聚体超细颗粒分离用于PEM水电解槽循环利用

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2025-11-17 DOI: 10.1016/j.jciso.2025.100161

Sohyun Ahn , Siddhi Kulkarni , Suvarna Patil , Urs A. Peuker , Martin Rudolph

As green hydrogen production via proton exchange membrane water electrolyzers (PEMELs) continues to scale up, the development of effective recycling processes for end-of-life components is becoming increasingly important. In PEMELs, ultrafine catalyst particles exhibit significant differences in hydrophobicity, which serve as a basis for selective separation. In this study, two separation techniques based on hydrophobicity differences (liquid–liquid particle separation and emulsion-based froth flotation) were proposed for particle recovery. Since catalyst inks contain amphiphilic ionomers as binders in addition to the particles, their influence on wettability-based separation was investigated. To clarify this effect, we investigated the physicochemical characteristics of ionomer-coated particles. Key parameters such as particle size, surface area (BET), and zeta potential were measured, and their impact on wettability was assessed. The results show that ionomer adsorption leads to a notable reduction in the hydrophobicity contrast, thereby hindering their selective separation. To address this issue, a dispersant was introduced to both separation processes. This addition improved the recovery performance, under conditions where the hydrophobicity difference was reduced (LLPS: recovery increased from 10 % to 70 %, froth flotation: approx. 15 % improvement). Although the addition of dispersants improved the recovery performance, the separation efficiency remained lower than that observed under ionomer-free conditions (over 95 % of recoveries in both processes). The findings highlight the complex interactions between particles, ionomers, and reagents in dispersion systems. Further investigation into these interactions is necessary to develop more robust and scalable recycling strategies. A deeper understanding of the physicochemical mechanisms will provide valuable insight into the design of selective separation processes for catalyst recovery in PEMEL systems.

随着质子交换膜水电解槽（PEMELs）绿色制氢的规模不断扩大，开发有效的报废部件回收工艺变得越来越重要。在PEMELs中，超细催化剂颗粒表现出显著的疏水性差异，这是选择性分离的基础。在本研究中，提出了两种基于疏水性差异的分离技术（液-液颗粒分离和乳化泡沫浮选）来回收颗粒。由于催化剂油墨除含有颗粒外还含有两亲性离聚物作为粘合剂，因此研究了它们对润湿性分离的影响。为了阐明这种效应，我们研究了离子单体包覆颗粒的物理化学特性。测量了颗粒大小、表面积（BET）和zeta电位等关键参数，并评估了它们对润湿性的影响。结果表明，离子异构体的吸附导致疏水性对比明显降低，从而阻碍了它们的选择性分离。为了解决这个问题，在两个分离过程中都引入了分散剂。在疏水性差减小的条件下，该添加剂提高了回收率（LLPS：回收率从10%提高到70%，泡沫浮选：约为70%）。改善15%)。虽然分散剂的加入提高了回收性能，但分离效率仍然低于无离聚体条件下的分离效率（两种工艺的回收率均在95%以上）。这些发现突出了分散系统中粒子、离聚体和试剂之间复杂的相互作用。进一步研究这些相互作用是必要的，以制定更强大和可扩展的回收策略。对物理化学机制的深入了解将为PEMEL系统中催化剂回收的选择性分离过程的设计提供有价值的见解。

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引用次数: 0

Functional protein films as interfacial coadjuvants: A synergistic strategy to enhance antibiotic efficacy and suppress biofilms 功能蛋白膜作为界面佐剂：增强抗生素疗效和抑制生物膜的协同策略

Q3 Materials Science

JCIS open

Pub Date : 2026-04-01 Epub Date: 2025-11-30 DOI: 10.1016/j.jciso.2025.100166

Ivon Y. Calibio Giraldo , Fiorela Ghilini , Eduardo Prieto , Carolina Díaz , Patricia L. Schilardi

Protein self-assembly at interfaces provides a versatile strategy to engineer functional coatings with applications spanning nanomedicine and advanced materials. Medical tubing-associated infections remain a critical healthcare challenge, driven by biofilm formation and antimicrobial resistance. We present a simple and scalable strategy to address this problem using bovine serum albumin (BSA) amyloid-like coatings applied to polyvinyl chloride (PVC), a widely used biomaterial and glass, as model surface. The coatings were formed by controlled disulfide reduction with dithiothreitol (DTT), yielding robust, adherent films stable under aqueous and mechanical stress. In contrast to earlier syntheses with tris(2-carboxyethyl)phosphine (TCEP), the DTT-based method provides a safer, low-cost route that preserves the physicochemical and anti-biofouling properties of the coatings.

Physicochemical characterization revealed that the coatings altered wettability, nanoscale roughness, and interfacial chemistry, resulting in strong suppression of both bacterial (Staphylococcus aureus) and mammalian cell adhesion. Importantly, the anti-adhesive properties originated from the chemical nature of the amyloid aggregates rather than topography alone, emphasizing the role of molecular interactions in modulating cell–surface behavior. While coatings alone suppressed bacterial colonization, residual loads approached infection-risk thresholds; combining the coatings with vancomycin at one-eigth the minimum inhibitory concentration achieved complete eradication of sessile and planktonic bacteria. The observed synergy illustrates that functional protein films serve as interfacial coadjuvants, enhancing antibiotic action while minimizing dosage, thereby limiting the development of resistance. Consequently, amyloid aggregates represent a class of self-assembled nanostructures that connect fundamental colloid and interface science with practical biomedical applications.

蛋白质在界面上的自组装为设计功能涂层提供了一种通用的策略，其应用跨越纳米医学和先进材料。由生物膜形成和抗菌素耐药性驱动的医疗管道相关感染仍然是一个关键的医疗保健挑战。我们提出了一个简单和可扩展的策略来解决这个问题，使用牛血清白蛋白（BSA）淀粉样涂层应用于聚氯乙烯（PVC），一种广泛使用的生物材料和玻璃，作为模型表面。用二硫苏糖醇（DTT）控制二硫还原形成涂层，得到坚固的、在水和机械应力下稳定的粘附膜。与早期用三（2-羧基乙基）膦（TCEP）合成相比，基于dtt的方法提供了一种更安全、低成本的方法，同时保留了涂层的物理化学和抗生物污染性能。理化表征表明，涂层改变了润湿性、纳米级粗糙度和界面化学，从而强烈抑制了细菌（金黄色葡萄球菌）和哺乳动物细胞的粘附。重要的是，抗粘接特性源于淀粉样蛋白聚集体的化学性质，而不仅仅是地形，强调了分子相互作用在调节细胞表面行为中的作用。虽然涂层单独抑制细菌定植，但残余负荷接近感染风险阈值；以最低抑菌浓度的八分之一将涂层与万古霉素结合，实现了对固定性和浮游细菌的完全根除。观察到的协同作用表明，功能性蛋白质膜作为界面辅助剂，增强抗生素作用，同时最小化剂量，从而限制耐药性的发展。因此，淀粉样蛋白聚集体代表了一类自组装的纳米结构，将基础胶体和界面科学与实际生物医学应用联系起来。

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引用次数: 0