Technological advances in fibrin for tissue engineering.

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING Journal of Tissue Engineering Pub Date : 2023-01-01 DOI:10.1177/20417314231190288
Raúl Sanz-Horta, Ana Matesanz, Alberto Gallardo, Helmut Reinecke, José Luis Jorcano, Pablo Acedo, Diego Velasco, Carlos Elvira
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引用次数: 2

Abstract

Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its characteristics must be improved for suitability for general use. For example, fibrin hydrogels tend to shrink and degrade quickly after polymerization, particularly when they contain embedded cells. In addition, their poor mechanical properties and batch-to-batch variability affect their handling, long-term stability, standardization, and reliability. One of the most widely used approaches to improve their properties has been modification of the structure and composition of fibrin hydrogels. In this review, recent advances in composite fibrin scaffolds, chemically modified fibrin hydrogels, interpenetrated polymer network (IPN) hydrogels composed of fibrin and other synthetic or natural polymers are critically reviewed, focusing on their use for tissue engineering.

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组织工程中纤维蛋白的技术进展。
纤维蛋白是一种很有前途的天然高分子材料,在止血胶、药物和细胞传递载体、组织工程基质等方面有着广泛的应用。尽管纤维蛋白在生物工程和生物医学应用方面取得了重大进展,但它的一些特性必须得到改善,才能适用于一般用途。例如,纤维蛋白水凝胶倾向于在聚合后迅速收缩和降解,特别是当它们含有嵌入的细胞时。此外,它们较差的机械性能和批次间的可变性影响了它们的处理、长期稳定性、标准化和可靠性。改善纤维蛋白水凝胶性能的最广泛应用的方法之一是改变纤维蛋白水凝胶的结构和组成。本文综述了复合纤维蛋白支架、化学修饰纤维蛋白水凝胶、纤维蛋白和其他合成或天然聚合物组成的互渗透聚合物网络(IPN)水凝胶的最新进展,重点介绍了它们在组织工程中的应用。
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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
期刊最新文献
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