An epidemic dynamics model with limited isolation capacity.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-09-01 DOI:10.1007/s12064-023-00399-9
Ishfaq Ahmad, Hiromi Seno
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Abstract

We consider a modified SIR model with a four-dimensional system of ordinary differential equations to consider the influence of a limited isolation capacity on the final epidemic size defined as the total number of individuals who experienced the disease at the end of an epidemic season. We derive the necessary and sufficient condition that the isolation reaches the capacity in a finite time on the way of the epidemic process, and show that the final epidemic size is monotonically decreasing in terms of the isolation capacity. We find further that the final epidemic size could have a discontinuous change at the critical value of isolation capacity below which the isolation reaches the capacity in a finite time. Our results imply that the breakdown of isolation with a limited capacity would cause a drastic increase of the epidemic size. Insufficient capacity of the isolation could lead to an unexpectedly severe epidemic situation, while such a severity would be avoidable with the sufficient isolation capacity.

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具有有限隔离能力的流行病动力学模型。
我们考虑了一个带有四维常微分方程系统的改进SIR模型,以考虑有限隔离能力对最终流行规模的影响,最终流行规模定义为在流行季节结束时经历该疾病的个体总数。导出了隔离在有限时间内达到隔离能力的充分必要条件,并证明了最终的流行病规模随隔离能力单调减小。我们进一步发现,在隔离能力临界值处,最终疫情规模可能发生不连续变化,在该临界值以下,隔离将在有限时间内达到隔离能力。我们的结果表明,以有限的能力打破隔离将导致流行病规模的急剧增加。隔离能力不足可能导致意外严重的疫情,而如果隔离能力足够,这种严重的疫情是可以避免的。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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