Stephanie A Ruderman, Allison R Webel, Amanda L Willig, Lydia N Drumright, Annette L Fitzpatrick, Michelle C Odden, John D Cleveland, Greer Burkholder, Christine H Davey, Julia Fleming, Thomas W Buford, Raymond Jones, Robin M Nance, Bridget M Whitney, L Sarah Mixson, Andrew W Hahn, Kenneth H Mayer, Meredith Greene, Michael S Saag, Charles Kamen, Chintan Pandya, William B Lober, Mari M Kitahata, Paul K Crane, Heidi M Crane, Joseph A C Delaney
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引用次数: 2
Abstract
Abstract: Modifications to Fried's frailty phenotype (FFP) are common. We evaluated a self-reported modified frailty phenotype (Mod-FP) used among people with HIV (PWH). Among 522 PWH engaged in two longitudinal studies, we assessed validity of the four-item Mod-FP compared with the five-item FFP. We compared the phenotypes via receiver operator characteristic curves, agreement in classifying frailty, and criterion validity via association with having experienced falls. Mod-FP classified 8% of PWH as frail, whereas FFP classified 9%. The area under the receiver operator characteristic curve for Mod-FP classifying frailty was 0.93 (95% CI = 0.91-0.96). We observed kappa ranging from 0.64 (unweighted) to 0.75 (weighted) for categorizing frailty status. Both definitions found frailty associated with a greater odds of experiencing a fall; FFP estimated a slightly greater magnitude (i.e., OR) for the association than Mod-FP. The Mod-FP has good performance in measuring frailty among PWH and is reasonable to use when the gold standards of observed assessments (i.e., weakness and slowness) are not feasible.
摘要:Fried's脆性表型(FFP)的修饰是常见的。我们评估了HIV感染者(PWH)中使用的自我报告的改良脆弱表型(Mod-FP)。在522名从事两项纵向研究的PWH中,我们比较了四项Mod-FP与五项FFP的效度。我们通过受体操作者特征曲线比较表型,在分类虚弱方面的一致性,以及通过与经历过跌倒的关联来比较标准效度。Mod-FP将8%的PWH归为虚弱,而FFP将9%归为虚弱。Mod-FP分类脆弱的受体操作者特征曲线下面积为0.93 (95% CI = 0.91-0.96)。我们观察到kappa在0.64(未加权)到0.75(加权)之间对虚弱状态进行分类。两种定义都发现,身体虚弱与摔倒的几率更大有关;与Mod-FP相比,FFP估计的关联程度(即OR)略大。Mod-FP在测量PWH的脆弱性方面具有良好的性能,并且在观察评估的金标准(即弱点和缓慢)不可行的情况下使用是合理的。
期刊介绍:
The Journal of the Association of Nurses in AIDS Care (JANAC) is a peer-reviewed, international nursing journal that covers the full spectrum of the global HIV epidemic, focusing on prevention, evidence-based care management, interprofessional clinical care, research, advocacy, policy, education, social determinants of health, epidemiology, and program development. JANAC functions according to the highest standards of ethical publishing practices and offers innovative publication options, including Open Access and prepublication article posting, where the journal can post articles before they are published with an issue.