The heterocellular heart: identities, interactions, and implications for cardiology.

IF 7.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Basic Research in Cardiology Pub Date : 2023-07-26 DOI:10.1007/s00395-023-01000-6
Achim Lother, Peter Kohl
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Abstract

The heterocellular nature of the heart has been receiving increasing attention in recent years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes such as endothelial cells, fibroblasts, or immune cells are coming more into focus. The rise of single-cell sequencing technologies enables  identification of ever more subtle differences and has reignited the question of what defines a cell's identity. Here we provide an overview of the major cardiac cell types, describe their roles in homeostasis, and outline recent findings on non-canonical functions that may be of relevance for cardiology. We highlight modes of biochemical and biophysical interactions between different cardiac cell types and discuss the potential implications of the heterocellular nature of the heart for basic research and therapeutic interventions.

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异细胞心脏:特性、相互作用及对心脏病学的影响。
近年来,心脏的异细胞特性日益受到关注。除了作为心脏原型细胞类型的心肌细胞外,内皮细胞、成纤维细胞或免疫细胞等非心肌细胞也越来越受到关注。单细胞测序技术的兴起使人们能够识别更微妙的差异,并再次引发了细胞身份的定义问题。在此,我们概述了主要的心脏细胞类型,描述了它们在体内平衡中的作用,并概述了可能与心脏病学有关的非典型功能的最新发现。我们强调了不同心脏细胞类型之间的生化和生物物理相互作用模式,并讨论了心脏的异细胞特性对基础研究和治疗干预的潜在影响。
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来源期刊
Basic Research in Cardiology
Basic Research in Cardiology 医学-心血管系统
CiteScore
16.30
自引率
5.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Basic Research in Cardiology is an international journal for cardiovascular research. It provides a forum for original and review articles related to experimental cardiology that meet its stringent scientific standards. Basic Research in Cardiology regularly receives articles from the fields of - Molecular and Cellular Biology - Biochemistry - Biophysics - Pharmacology - Physiology and Pathology - Clinical Cardiology
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