Lymphocyte Subsets Are Associated with Disease Status in Neuromyelitis Optica Spectrum Disorders.

IF 2.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Neuroimmunomodulation Pub Date : 2022-01-01 DOI:10.1159/000520745

Hong Yang, Wei Liu, Yi-Fan Wu, De-Sheng Zhu, Xia-Feng Shen, Yang-Tai Guan

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引用次数: 2

Abstract

Objective: At present, studies on lymphocytes are mostly conducted on CD19+ B cells and CD27+ B cells in neuromyelitis optica spectrum disorders (NMOSDs), but the exact changes in lymphocyte subsets (CD19+ B cells, CD3+ T cells, CD4+ Th cells, CD8+ Ts cells, the CD4+/CD8+ ratio, and NK [CD56+ CD16] cells) have rarely been studied. This study aimed to assess lymphocyte subset changes in patients with NMOSD.

Methods: We performed a cross-sectional study of consecutive patients with acute NMOSD (n = 41), chronic NMOSD (n = 21), and healthy individuals (n = 44). Peripheral blood samples were obtained upon admission, and lymphocyte subsets were analyzed by flow cytometry. Levels of lymphocyte subsets among 3 groups were compared and its correlation with the length of spinal cord lesions was analyzed.

Results: The levels of peripheral blood CD19+ B cells were significantly higher in patients with acute and chronic NMOSD than in healthy controls (HCs) (17.91 ± 8.7%, 13.08 ± 7.562%, and 12.48 ± 3.575%, respectively; p < 0.001) and were positively correlated with the length of spinal cord lesions in acute NMOSD (r = 0.433, p < 0.05). The peripheral blood CD4+/CD8+ ratio was significantly lower in patients with acute NMOSD and chronic NMOSD than in HCs (1.497 ± 0.6387, 1.33 ± 0.5574, and 1.753 ± 0.659, respectively; p < 0.05), and the levels of peripheral blood NK (CD56+ CD16) cells were significantly lower in patients with acute and chronic NMOSD than in HCs (13.6 ± 10.13, 11.11 ± 7.057, and 14.7 [interquartile range = 9.28], respectively; p < 0.01).

Conclusions: The levels of certain subsets of peripheral blood lymphocytes are associated with disease status in NMOSD.

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淋巴细胞亚群与视神经脊髓炎谱系障碍的疾病状态相关

目的:目前对淋巴细胞的研究多针对视神经脊髓炎谱系障碍(NMOSDs)患者的CD19+ B细胞和CD27+ B细胞，但对淋巴细胞亚群(CD19+ B细胞、CD3+ T细胞、CD4+ Th细胞、CD8+ T细胞、CD4+/CD8+比值、NK [CD56+ CD16]细胞)的确切变化研究甚少。本研究旨在评估NMOSD患者淋巴细胞亚群的变化。方法:我们对急性NMOSD患者(n = 41)、慢性NMOSD患者(n = 21)和健康个体(n = 44)进行了横断面研究。入院时采集外周血标本，流式细胞术分析淋巴细胞亚群。比较3组患者淋巴细胞亚群水平，并分析其与脊髓病变长度的相关性。结果:急性和慢性NMOSD患者外周血CD19+ B细胞水平显著高于健康对照组(HCs)，分别为17.91±8.7%、13.08±7.562%和12.48±3.575%;p < 0.001)，且与急性NMOSD脊髓损伤长度呈正相关(r = 0.433, p < 0.05)。急性NMOSD和慢性NMOSD患者外周血CD4+/CD8+比值明显低于hc患者(分别为1.497±0.6387、1.33±0.5574和1.753±0.659);急性和慢性NMOSD患者外周血NK (CD56+ CD16)细胞水平显著低于hc患者(分别为13.6±10.13、11.11±7.057和14.7[四分位数间距= 9.28];P < 0.01)。结论:某些外周血淋巴细胞亚群的水平与NMOSD的疾病状态相关。

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来源期刊

Neuroimmunomodulation 医学-免疫学

CiteScore

3.60

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.