Amoebae: Hiding in Plain Sight: Unappreciated Hosts for the Very Large Viruses.

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2022-09-29 DOI:10.1146/annurev-virology-100520-125832
Victória Fulgêncio Queiroz, Rodrigo Araújo Lima Rodrigues, Paulo Victor de Miranda Boratto, Bernard La Scola, Julien Andreani, Jônatas Santos Abrahão
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引用次数: 6

Abstract

For decades, viruses have been isolated primarily from humans and other organisms. Interestingly, one of the most complex sides of the virosphere was discovered using free-living amoebae as hosts. The discovery of giant viruses in the early twenty-first century opened a new chapter in the field of virology. Giant viruses are included in the phylum Nucleocytoviricota and harbor large and complex DNA genomes (up to 2.7 Mb) encoding genes never before seen in the virosphere and presenting gigantic particles (up to 1.5 μm). Different amoebae have been used to isolate and characterize a plethora of new viruses with exciting details about novel viral biology. Through distinct isolation techniques and metagenomics, the diversity and complexity of giant viruses have astonished the scientific community. Here, we discuss the latest findings on amoeba viruses and how using these single-celled organisms as hosts has revealed entities that have remained hidden in plain sight for ages.

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变形虫:隐藏在显眼的地方:超大病毒未被发现的宿主。
几十年来,病毒主要是从人类和其他生物体中分离出来的。有趣的是,人们发现病毒圈最复杂的一面是使用自由生活的变形虫作为宿主。21世纪初巨型病毒的发现开启了病毒学领域的新篇章。巨型病毒包括在核细胞病毒门中,具有大而复杂的DNA基因组(高达2.7 Mb),编码病毒圈中从未见过的基因,并呈现巨大的颗粒(高达1.5 μm)。不同的变形虫被用来分离和表征大量的新病毒,并提供了关于新病毒生物学的令人兴奋的细节。通过不同的分离技术和宏基因组学,巨型病毒的多样性和复杂性震惊了科学界。在这里,我们讨论关于变形虫病毒的最新发现,以及如何使用这些单细胞生物作为宿主揭示了多年来一直隐藏在视线之外的实体。
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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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