Bacteriophage T4 as a Protein-Based, Adjuvant- and Needle-Free, Mucosal Pandemic Vaccine Design Platform.

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI:10.1146/annurev-virology-111821-111145
Jingen Zhu, Pan Tao, Ashok K Chopra, Venigalla B Rao
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Abstract

The COVID-19 pandemic has transformed vaccinology. Rapid deployment of mRNA vaccines has saved countless lives. However, these platforms have inherent limitations including lack of durability of immune responses and mucosal immunity, high cost, and thermal instability. These and uncertainties about the nature of future pandemics underscore the need for exploring next-generation vaccine platforms. Here, we present a novel protein-based, bacteriophage T4 platform for rapid design of efficacious vaccines against bacterial and viral pathogens. Full-length antigens can be displayed at high density on a 120 × 86 nm phage capsid through nonessential capsid binding proteins Soc and Hoc. Such nanoparticles, without any adjuvant, induce robust humoral, cellular, and mucosal responses when administered intranasally and confer sterilizing immunity. Combined with structural stability and ease of manufacture, T4 phage provides an excellent needle-free, mucosal pandemic vaccine platform and allows equitable vaccine access to low- and middle-income communities across the globe.

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将噬菌体 T4 作为基于蛋白质、无佐剂和无针头的黏膜大流行病疫苗设计平台。
COVID-19 大流行改变了疫苗学。mRNA 疫苗的快速应用挽救了无数生命。然而,这些平台存在固有的局限性,包括免疫反应和粘膜免疫缺乏持久性、成本高昂以及热不稳定性。这些问题以及未来大流行病性质的不确定性突出表明了探索下一代疫苗平台的必要性。在这里,我们提出了一种基于蛋白质的新型噬菌体 T4 平台,用于快速设计针对细菌和病毒病原体的高效疫苗。通过非必要的噬菌体结合蛋白 Soc 和 Hoc,全长抗原可以高密度地显示在 120 × 86 nm 的噬菌体外壳上。这种纳米颗粒不含任何佐剂,经鼻内给药后可诱导强有力的体液、细胞和粘膜反应,并赋予灭菌免疫力。T4 噬菌体结构稳定,易于制造,是一种出色的无针粘膜大流行病疫苗平台,可为全球中低收入社区提供公平的疫苗接种机会。
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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
期刊最新文献
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