Is Celiac Disease (CD) Prevalent in Patients with Multiple Sclerosis (MS): A Systematic Review and Meta-Analysis.

IF 2.2 Q3 CLINICAL NEUROLOGY Multiple Sclerosis International Pub Date : 2022-01-01 DOI:10.1155/2022/7091140

Hamide Olfati, Hamed Ghoshouni, Narges Ebrahimi, Aida Mohammadi, Mahsa Ghajarzadeh

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Abstract

Background: Celiac disease (CD) is an autoimmune disease, and its prevalence reported variously in different studies. The goal of this study is to evaluate the pooled prevalence of CD in subjects with MS.

Methods: PubMed, Scopus, EMBASE, Web of Science, and Google Scholar along with gray literature were systematically searched. The search included all relevant studies which were published up to October 2022. Two researchers independently searched all databases and also references of included studies.

Results: We found 8211 articles by literature search, and after deleting duplicates, 5594 remained. Fifteen articles remained for meta-analysis. Totally, 31418 patients were evaluated, and the total number of possible/confirmed cases was 124. Studies were published between 2004 and 2020, and the most published studies were from Italy. Five studies provided information regarding controls. The total number of controls was 22394, of whom 22 had CD. Mean age ranged from 35 to 55 years. The pooled prevalence of CD in MS patients was 0 (I ² = 88.2%, p < 0.001). The pooled odds of CD in subjects with MS are 0.46 (95% CI: 0.19-1.1) (I ² = 0, p = 0.9).

Conclusion: The pooled prevalence of this systematic review showed that CD is not prevalent in MS cases.

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乳糜泻(CD)在多发性硬化症(MS)患者中普遍存在吗:一项系统综述和荟萃分析

背景:乳糜泻(CD)是一种自身免疫性疾病，其患病率在不同的研究中有不同的报道。方法:系统检索PubMed、Scopus、EMBASE、Web of Science和Google Scholar以及灰色文献。搜索包括截至2022年10月发表的所有相关研究。两位研究者独立检索了所有数据库和纳入研究的参考文献。结果:通过文献检索得到8211篇文献，删除重复文献后，只剩下5594篇。剩下15篇文章用于荟萃分析。共评估病例31418例，疑似/确诊病例124例。这些研究发表于2004年至2020年之间，发表最多的研究来自意大利。五项研究提供了有关对照的信息。对照组总人数为22394人，其中22人患有乳糜泻，平均年龄为35 - 55岁。MS患者CD的总患病率为0 (i2 = 88.2%， p < 0.001)。多发性硬化症患者发生CD的总几率为0.46 (95% CI: 0.19-1.1) (i2 = 0, p = 0.9)。结论:本系统综述的总患病率显示，CD在MS病例中并不普遍。

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来源期刊

Multiple Sclerosis International CLINICAL NEUROLOGY-

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0.00%

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审稿时长

15 weeks

期刊介绍： Multiple Sclerosis International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of multiple sclerosis, including clinical neurology, neuroimaging, neuropathology, therapeutics, genetics, neuroimmunology, biomarkers, psychology and neurorehabilitation.