Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division

IF 2.5 Q2 PHYSIOLOGY Current Opinion in Physiology Pub Date : 2022-10-01 DOI:10.1016/j.cophys.2022.100574
Jason A Mears , Rajesh Ramachandran
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引用次数: 1

Abstract

Dynamin-related protein 1 (Drp1), the master regulator of mitochondrial division (MD), interacts with the cytoskeletal elements, namely filamentous actin, microtubules, and septins that coincidentally converge at MD sites. However, the mechanistic contributions of these critical elements to, and their cooperativity in, MD remain poorly characterized. Emergent data indicate that the cytoskeleton plays combinatorial modulator, mediator, and effector roles in MD by ‘priming’ and ‘channeling’ Drp1 for mechanoenzymatic membrane remodeling. In this brief review, we will outline our current understanding of Drp1–cytoskeleton interactions, focusing on recent progress in the field and a plausible ‘diffusion barrier’ role for the cytoskeleton in MD.

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Drp1和细胞骨架:线粒体分裂的机制联系。
Dynamin相关蛋白1(Drp1)是线粒体分裂(MD)的主要调节因子,与细胞骨架元件相互作用,即丝状肌动蛋白(F-actin)、微管(MT)和间隔蛋白,它们巧合地聚集在MD位点。然而,这些关键元素对MD的机械贡献及其在MD中的协同作用仍然很差。新兴数据表明,细胞骨架通过“启动”和“引导”Drp1进行机械接合膜重塑,在MD中发挥组合调节剂、介质和效应器作用。在这篇简短的综述中,我们将概述我们目前对Drp1细胞骨架相互作用的理解,重点关注该领域的最新进展以及细胞骨架在MD中可能的“扩散屏障”作用。
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来源期刊
Current Opinion in Physiology
Current Opinion in Physiology Medicine-Physiology (medical)
CiteScore
5.80
自引率
0.00%
发文量
52
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