Pub Date : 2024-08-23DOI: 10.1016/j.cophys.2024.100778
{"title":"Editorial Overview: Adrenergic signaling in cellular physiology and disease","authors":"","doi":"10.1016/j.cophys.2024.100778","DOIUrl":"10.1016/j.cophys.2024.100778","url":null,"abstract":"","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-22DOI: 10.1016/j.cophys.2024.100777
{"title":"Editorial overview: Sex differences in personalized medicine and beyond","authors":"","doi":"10.1016/j.cophys.2024.100777","DOIUrl":"10.1016/j.cophys.2024.100777","url":null,"abstract":"","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.1016/j.cophys.2024.100766
Lilly Underwood, Chun-sun Jiang, Joo-Yeun Oh, Priscila Y Sato
Catecholamines (CAs) bind and activate adrenergic receptors (ARs), thus exuding a key role in cardiac adaptations to global physiological queues. Prolonged exposure to high levels of CAs promotes deleterious effects on the cardiovascular system, leading to organ dysfunction and heart failure (HF). In addition to the prominent role of ARs in inotropic and chronotropic responses, recent studies have delved into elucidating mechanisms contributing to CA toxicity and cell death. Central to this process is understanding the involvement of α1AR and βAR in cardiac remodeling and mechanisms of cellular survival. Here, we highlight the complexity of AR signaling and the fundamental need for a better understanding of its contribution to oxidative stress and cell death. This crucial informational nexus remains a barrier to the development of new therapeutic strategies for cardiovascular diseases.
儿茶酚胺(CA)能结合并激活肾上腺素能受体(AR),因此在心脏适应全球生理变化的过程中发挥着关键作用。长期暴露于高水平的 CAs 会对心血管系统产生有害影响,导致器官功能障碍和心力衰竭(HF)。除了 ARs 在肌力和时脉反应中的突出作用外,最近的研究还深入探讨了导致 CA 毒性和细胞死亡的机制。这一过程的核心是了解α1AR和βAR参与心脏重塑和细胞存活的机制。在此,我们强调了 AR 信号传导的复杂性,以及更好地了解其对氧化应激和细胞死亡的贡献的根本必要性。这一重要的信息联系仍然是开发心血管疾病新疗法的障碍。
{"title":"Unheralded adrenergic receptor signaling in cellular oxidative stress and death","authors":"Lilly Underwood, Chun-sun Jiang, Joo-Yeun Oh, Priscila Y Sato","doi":"10.1016/j.cophys.2024.100766","DOIUrl":"https://doi.org/10.1016/j.cophys.2024.100766","url":null,"abstract":"<div><p>Catecholamines (CAs) bind and activate adrenergic receptors (ARs), thus exuding a key role in cardiac adaptations to global physiological queues. Prolonged exposure to high levels of CAs promotes deleterious effects on the cardiovascular system, leading to organ dysfunction and heart failure (HF). In addition to the prominent role of ARs in inotropic and chronotropic responses, recent studies have delved into elucidating mechanisms contributing to CA toxicity and cell death. Central to this process is understanding the involvement of α1AR and βAR in cardiac remodeling and mechanisms of cellular survival. Here, we highlight the complexity of AR signaling and the fundamental need for a better understanding of its contribution to oxidative stress and cell death. This crucial informational nexus remains a barrier to the development of new therapeutic strategies for cardiovascular diseases.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-11DOI: 10.1016/j.cophys.2024.100765
Yohan Kim , Pasquale D’Acunzo , Efrat Levy
In the brain, mitochondrial components are released into the extracellular space via several mechanisms, including a recently identified type of extracellular vesicles called mitovesicles. While vesiculation of neuronal mitochondria yields various intracellular types of vesicles, with either a single or a double membrane, mitovesicles secreted into the extracellular space are a unique subtype of these mitochondria-derived vesicles, with a double membrane and a specific set of mitochondrial DNA, RNA, proteins, and lipids. Based on the most relevant literature describing mitochondrial vesiculation and mitochondrial exocytosis, we propose a model for their secretion when the amphisomes, a hybrid endosome–autophagosome organelle, fuse with the plasma membrane, releasing mitovesicles and exosomes into the extracellular space. In aging and neurodegenerative disorders, mitochondrial dysfunction, in association with endolysosomal abnormalities, alter mitovesicle number and content, with downstream effect on brain health.
{"title":"Biogenesis and secretion of mitovesicles, small extracellular vesicles of mitochondrial origin at the crossroads between brain health and disease","authors":"Yohan Kim , Pasquale D’Acunzo , Efrat Levy","doi":"10.1016/j.cophys.2024.100765","DOIUrl":"10.1016/j.cophys.2024.100765","url":null,"abstract":"<div><p>In the brain, mitochondrial components are released into the extracellular space via several mechanisms, including a recently identified type of extracellular vesicles called mitovesicles. While vesiculation of neuronal mitochondria yields various intracellular types of vesicles, with either a single or a double membrane, mitovesicles secreted into the extracellular space are a unique subtype of these mitochondria-derived vesicles, with a double membrane and a specific set of mitochondrial DNA, RNA, proteins, and lipids. Based on the most relevant literature describing mitochondrial vesiculation and mitochondrial exocytosis, we propose a model for their secretion when the amphisomes, a hybrid endosome–autophagosome organelle, fuse with the plasma membrane, releasing mitovesicles and exosomes into the extracellular space. In aging and neurodegenerative disorders, mitochondrial dysfunction, in association with endolysosomal abnormalities, alter mitovesicle number and content, with downstream effect on brain health.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-31DOI: 10.1016/j.cophys.2024.100764
Worawan B Limpitikul , Marta Garcia-Contreras , Saumya Das
Cardiometabolic diseases (CMDs) are a leading contributor to worldwide morbidity and mortality. Recent insights into the pathogenesis of CMDs reveal crucial roles of intercellular crosstalk between metabolically active organs and cardiac cells. In this context, extracellular vesicles (EVs), lipid membrane-delimited particles containing diverse cargo (including small and long RNAs, proteins, lipids, and metabolites), and nonvesicular extracellular particles (NVEPs) have emerged as key mediators of cell-to-cell communications. EV cargo can reflect the metabolic state of their cells of origin and affect the function of their target cells. Understanding EV cargo content and function is essential for unraveling the pathophysiology of CMDs. This mini-review describes recent studies on EV-mediated local and interorgan crosstalk in CMDs, focusing on those that lead to atrial and ventricular myopathy, which are hallmarks of atrial fibrillation and heart failure, respectively. Lastly, this review discusses the potential applications of EVs in the diagnostics and therapeutics of these CMDs.
心脏代谢疾病(CMDs)是导致全球发病率和死亡率的主要因素。最近对 CMD 发病机理的深入研究表明,代谢活跃的器官和心脏细胞之间的细胞间串扰起着至关重要的作用。在此背景下,细胞外囊泡 (EV)、含有多种货物(包括长短核糖核酸、蛋白质、脂质和代谢物)的脂膜限制颗粒以及非囊泡细胞外颗粒 (NVEP) 成为细胞间通信的关键媒介。EV货物可以反映其来源细胞的代谢状态,并影响其靶细胞的功能。了解 EV 货物的内容和功能对于揭示 CMD 的病理生理学至关重要。这篇微型综述介绍了有关 EV 在 CMDs 中介导的局部和器官间串联的最新研究,重点是那些导致心房和心室肌病的研究,这分别是心房颤动和心力衰竭的标志。最后,本综述讨论了 EV 在这些 CMD 的诊断和治疗中的潜在应用。
{"title":"The emerging role of extracellular vesicle RNAs as mediators of cardiometabolic diseases: from pathophysiology to clinical applications","authors":"Worawan B Limpitikul , Marta Garcia-Contreras , Saumya Das","doi":"10.1016/j.cophys.2024.100764","DOIUrl":"https://doi.org/10.1016/j.cophys.2024.100764","url":null,"abstract":"<div><p>Cardiometabolic diseases (CMDs) are a leading contributor to worldwide morbidity and mortality. Recent insights into the pathogenesis of CMDs reveal crucial roles of intercellular crosstalk between metabolically active organs and cardiac cells. In this context, extracellular vesicles (EVs), lipid membrane-delimited particles containing diverse cargo (including small and long RNAs, proteins, lipids, and metabolites), and nonvesicular extracellular particles (NVEPs) have emerged as key mediators of cell-to-cell communications. EV cargo can reflect the metabolic state of their cells of origin and affect the function of their target cells. Understanding EV cargo content and function is essential for unraveling the pathophysiology of CMDs. This mini-review describes recent studies on EV-mediated local and interorgan crosstalk in CMDs, focusing on those that lead to atrial and ventricular myopathy, which are hallmarks of atrial fibrillation and heart failure, respectively. Lastly, this review discusses the potential applications of EVs in the diagnostics and therapeutics of these CMDs.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-23DOI: 10.1016/j.cophys.2024.100755
Marina Pérez-Capó , Antònia Obrador-Hevia , Diego de Miguel-Perez , Christian Rolfo
The battle against cancer remains a formidable challenge despite ongoing efforts worldwide. Current treatments are limited, leading to increased interest in personalized approaches, including drug delivery via extracellular vesicles (EVs). EVs are lipid bilayer particles released by cells that play a crucial role in intercellular communication by transferring biological compounds. Recent preclinical studies have demonstrated that EVs are also effective delivery vehicles for other cargo, such as chemotherapeutic drugs, immunotherapeutic agents, or nucleic acid–based therapeutics with improved pharmacokinetics. This review focuses on the latest advances on EVs as drug carriers in cancer therapy, pointing out the current ongoing clinical trials testing the potential of molecules, such as interleukin-12, STING agonists, or KRAS-G12D small interfering RNA. The evolving landscape of EVs in targeted cancer therapeutics holds significant promise for developing safer, personalized, and cell-free therapies.
{"title":"Engineered extracellular vesicles for cancer drug delivery and therapeutics","authors":"Marina Pérez-Capó , Antònia Obrador-Hevia , Diego de Miguel-Perez , Christian Rolfo","doi":"10.1016/j.cophys.2024.100755","DOIUrl":"10.1016/j.cophys.2024.100755","url":null,"abstract":"<div><p>The battle against cancer remains a formidable challenge despite ongoing efforts worldwide. Current treatments are limited, leading to increased interest in personalized approaches, including drug delivery via extracellular vesicles (EVs). EVs are lipid bilayer particles released by cells that play a crucial role in intercellular communication by transferring biological compounds. Recent preclinical studies have demonstrated that EVs are also effective delivery vehicles for other cargo, such as chemotherapeutic drugs, immunotherapeutic agents, or nucleic acid–based therapeutics with improved pharmacokinetics. This review focuses on the latest advances on EVs as drug carriers in cancer therapy, pointing out the current ongoing clinical trials testing the potential of molecules, such as interleukin-12, STING agonists, or KRAS-G12D small interfering RNA. The evolving landscape of EVs in targeted cancer therapeutics holds significant promise for developing safer, personalized, and cell-free therapies.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.1016/j.cophys.2024.100746
Sergio G. Garcia , Marta Clos-Sansalvador , Marta Sanroque-Muñoz , Linrong Pan , Marcella Franquesa
Kidney diseases pose a significant challenge, lacking effective therapies. Extracellular vesicle (EV)-based therapies have emerged as a novel advanced therapeutic. Particularly, mesenchymal stromal cells (MSC) and their EV are being explored as potential candidates. While MSC-EV therapeutics offer promise, there is a lack of widely standardized potency tests to assess EV effectiveness. Tailoring potency assessment in kidney diseases requires considering multifactorial effects and may necessitate a combination of multiple assays to recapitulate EV function. The design of a matrix of assays will be specific for the chosen disease and will involve specific molecular mechanisms and biological processes. This review highlights recent MSC-EV functional assays focused on modeling kidney disease mechanisms of action.
{"title":"Functional and potency assays for mesenchymal stromal cell–extracellular vesicles in kidney disease","authors":"Sergio G. Garcia , Marta Clos-Sansalvador , Marta Sanroque-Muñoz , Linrong Pan , Marcella Franquesa","doi":"10.1016/j.cophys.2024.100746","DOIUrl":"https://doi.org/10.1016/j.cophys.2024.100746","url":null,"abstract":"<div><p>Kidney diseases pose a significant challenge, lacking effective therapies. Extracellular vesicle (EV)-based therapies have emerged as a novel advanced therapeutic. Particularly, mesenchymal stromal cells (MSC) and their EV are being explored as potential candidates. While MSC-EV therapeutics offer promise, there is a lack of widely standardized potency tests to assess EV effectiveness. Tailoring potency assessment in kidney diseases requires considering multifactorial effects and may necessitate a combination of multiple assays to recapitulate EV function. The design of a matrix of assays will be specific for the chosen disease and will involve specific molecular mechanisms and biological processes. This review highlights recent MSC-EV functional assays focused on modeling kidney disease mechanisms of action.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-12DOI: 10.1016/j.cophys.2023.100734
Giada Corti , Rene Buchet , Andrea Magrini , Pietro Ciancaglini , Saida Mebarek , Massimo Bottini
The diagnosis of breast cancer in the early stage is essential for a favorable prognosis. Extracellular vesicles isolated from body fluids have a central role in breast cancer development due to their biochemical components. Among the biochemical components, surface proteins mediate vesicle interactions with elements of the extracellular milieu, the extracellular matrix, and neighboring cells. The identification of specific surface proteomic profile has been regarded as an easy and reproducible means to define cancer parameters, identify markers for a diagnosis, and determine targets for therapeutical treatments. In this review, we will focus on annexins, tetraspanins, integrins, immune checkpoint proteins, and growth factor receptors that have been identified on the surface of extracellular vesicles isolated from the serum of patients with breast cancer and that have been found to be relevant diagnostic and prognostic biomarkers.
{"title":"The surface proteomic profile of serum extracellular vesicles as a diagnostic and prognostic tool in breast cancer","authors":"Giada Corti , Rene Buchet , Andrea Magrini , Pietro Ciancaglini , Saida Mebarek , Massimo Bottini","doi":"10.1016/j.cophys.2023.100734","DOIUrl":"10.1016/j.cophys.2023.100734","url":null,"abstract":"<div><p>The diagnosis of breast cancer in the early stage is essential for a favorable prognosis. Extracellular vesicles isolated from body fluids have a central role in breast cancer development due to their biochemical components. Among the biochemical components, surface proteins mediate vesicle interactions with elements of the extracellular milieu, the extracellular matrix, and neighboring cells. The identification of specific surface proteomic profile has been regarded as an easy and reproducible means to define cancer parameters, identify markers for a diagnosis, and determine targets for therapeutical treatments. In this review, we will focus on annexins, tetraspanins, integrins, immune checkpoint proteins, and growth factor receptors that have been identified on the surface of extracellular vesicles isolated from the serum of patients with breast cancer and that have been found to be relevant diagnostic and prognostic biomarkers.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867323001050/pdfft?md5=8fa9d5e9fec9ceaa07efb361c2b98d35&pid=1-s2.0-S2468867323001050-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-07DOI: 10.1016/j.cophys.2023.100733
Gizem Kayki-Mutlu, Ebru Arioglu-Inan
The cellular ‘powerhouse’, mitochondria play vital roles in cardiac cells, including the modulation of contractility. Among the various mechanisms, the modulation of cardiac mitochondria by adrenergic signaling stands out as a crucial component in orchestrating cardiac function. Adrenergic system serving as the primary regulator of cardiac contractility, exerts its effects through α- and ß-adrenoceptors, which are regulated by G-protein-coupled receptor kinase 2 (GRK2) and ß-arrestin. In recent years, it has been revealed that these components of adrenergic signaling interact with mitochondria in diverse ways. α- and ß-adrenoceptors are reported to contribute to mitochondrial biogenesis, dynamics, and function. Besides, GRK2 is known to be localized to mitochondria, following oxidative stress or ischemic injury, and exerts negative metabolic effects. In this review, we outlined the contributions of these pivotal elements of adrenergic signaling to mitochondrial function. The better understanding of this delicate relationship holds crucial implications for novel therapeutic options to treat cardiovascular pathologies.
线粒体是细胞的 "动力室",在心脏细胞中发挥着至关重要的作用,包括调节收缩力。在各种机制中,肾上腺素能信号对心脏线粒体的调节是协调心脏功能的重要组成部分。肾上腺素能系统是心脏收缩力的主要调节器,通过α-和ß-肾上腺素受体发挥作用,而α-和ß-肾上腺素受体又受 G 蛋白偶联受体激酶 2(GRK2)和ß-arrestin 的调节。据报道,α和ß肾上腺素受体有助于线粒体的生物生成、动力学和功能。此外,已知 GRK2 在氧化应激或缺血损伤后会定位到线粒体,并对新陈代谢产生负面影响。在这篇综述中,我们概述了肾上腺素能信号传导的这些关键因素对线粒体功能的贡献。更好地理解这种微妙的关系对治疗心血管疾病的新疗法具有重要意义。
{"title":"Cardiac adrenergic receptors and GRKs: mitochondrial modulation in the heart","authors":"Gizem Kayki-Mutlu, Ebru Arioglu-Inan","doi":"10.1016/j.cophys.2023.100733","DOIUrl":"10.1016/j.cophys.2023.100733","url":null,"abstract":"<div><p><span><span>The cellular ‘powerhouse’, mitochondria play vital roles in cardiac cells, including the modulation of contractility. Among the various mechanisms, the modulation of cardiac mitochondria by adrenergic signaling stands out as a crucial component in orchestrating cardiac function. Adrenergic system serving as the primary regulator of </span>cardiac contractility, exerts its effects through α- and ß-adrenoceptors, which are regulated by G-protein-coupled receptor kinase 2 (GRK2) and ß-arrestin. In recent years, it has been revealed that these components of adrenergic signaling interact with mitochondria in diverse ways. α- and ß-adrenoceptors are reported to contribute to </span>mitochondrial biogenesis<span>, dynamics, and function. Besides, GRK2 is known to be localized to mitochondria, following oxidative stress or ischemic injury, and exerts negative metabolic effects. In this review, we outlined the contributions of these pivotal elements of adrenergic signaling to mitochondrial function. The better understanding of this delicate relationship holds crucial implications for novel therapeutic options to treat cardiovascular pathologies.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138625464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1016/j.cophys.2023.100732
Medha Kanitkar, Christopher P Denton
Vasculopathy is a generic feature of autoimmune rheumatic disease and there is substantial evidence that endothelial cell dysfunction has a role in pathogenesis and clinical manifestations of this challenging group of diseases. Endothelial cells (EC) are a target for injury and through their essential functional role in vascular homoeostasis, this has significant impact. In addition, the emerging recognition that EC are important regulators of other cell types and can differentiate into other relevant cell types has direct relevance. These aspects are reviewed with a focus on recent published evidence regarding the importance of EC in development, progression and treatment of autoimmune rheumatic disease. The potential role of the adaptive and innate immune system in causing endothelial cell damage, including anti-endothelial cell autoantibodies, will be reviewed. Recent advances in understanding how EC may differentiate into mesenchymal lineages and the interplay between physiological roles in healing or tissue repair and dysfunctional responses in acquired connective tissue disease will be reviewed.
{"title":"The role of endothelial cells in autoimmune rheumatic disease","authors":"Medha Kanitkar, Christopher P Denton","doi":"10.1016/j.cophys.2023.100732","DOIUrl":"10.1016/j.cophys.2023.100732","url":null,"abstract":"<div><p>Vasculopathy is a generic feature of autoimmune rheumatic disease and there is substantial evidence that endothelial cell dysfunction has a role in pathogenesis and clinical manifestations of this challenging group of diseases. Endothelial cells (EC) are a target for injury and through their essential functional role in vascular homoeostasis, this has significant impact. In addition, the emerging recognition that EC are important regulators of other cell types and can differentiate into other relevant cell types has direct relevance. These aspects are reviewed with a focus on recent published evidence regarding the importance of EC in development, progression and treatment of autoimmune rheumatic disease. The potential role of the adaptive and innate immune system in causing endothelial cell damage, including anti-endothelial cell autoantibodies, will be reviewed. Recent advances in understanding how EC may differentiate into mesenchymal lineages and the interplay between physiological roles in healing or tissue repair and dysfunctional responses in acquired connective tissue disease will be reviewed.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867323001037/pdfft?md5=ac0864dcb763bc6948a89da29e1475ed&pid=1-s2.0-S2468867323001037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}