Reversal of uniocular blindness with corticosteroids in a solid organ transplant recipient with cryptococcal meningitis and immune reconstitution syndrome (IRIS): A case report

IF 2.2 4区医学 Q3 MYCOLOGY Journal de mycologie medicale Pub Date : 2023-08-01 DOI:10.1016/j.mycmed.2023.101406

Praveen Tirlangi , Hari Priya Reddy Challa , Sai Ram Keithi-Reddy , Venkata Krishna Chaitanya Koduri , R Sujith Reddy , Murthy NLN Arumilli , L Siva Kumar Reddy , Gayatri Senapathy

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引用次数: 1

Abstract

Cryptococcal meningitis is a life-threatening infection commonly seen in patients with advanced HIV infection and solid organ transplant recipients. We report a case of cryptococcal meningitis with immune reconstitution syndrome (IRIS) who presented to us with a headache and complete loss of vision in the left eye. He was managed with antifungals and a short course of steroids, and he regained vision completely. In the hospital, he developed complications including tacrolimus toxicity, fluconazole-induced QT prolongation, and flucytosine-induced thrombocytopenia. Our case demonstrates the importance of a multidisciplinary approach in the management of complex cases like cryptococcal meningitis in solid organ transplant recipients.

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使用皮质类固醇逆转伴有隐球菌脑膜炎和免疫重建综合征(IRIS)的实体器官移植受者单眼失明1例报告

隐球菌脑膜炎是一种危及生命的感染，常见于晚期HIV感染患者和实体器官移植受者。我们报告了一例伴有免疫重建综合征（IRIS）的隐球菌性脑膜炎病例，该病例表现为头痛和左眼完全失明。他接受了抗真菌药物和短期类固醇治疗，完全恢复了视力。在医院，他出现了并发症，包括他克莫司毒性、氟康唑诱导的QT延长和氟胞嘧啶诱导的血小板减少症。我们的病例证明了多学科方法在治疗实体器官移植受者隐球菌性脑膜炎等复杂病例中的重要性。

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来源期刊

Journal de mycologie medicale 医学-真菌学

CiteScore

5.10

自引率

2.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal de Mycologie Medicale / Journal of Medical Mycology (JMM) publishes in English works dealing with human and animal mycology. The subjects treated are focused in particular on clinical, diagnostic, epidemiological, immunological, medical, pathological, preventive or therapeutic aspects of mycoses. Also covered are basic aspects linked primarily with morphology (electronic and photonic microscopy), physiology, biochemistry, cellular and molecular biology, immunochemistry, genetics, taxonomy or phylogeny of pathogenic or opportunistic fungi and actinomycetes in humans or animals. Studies of natural products showing inhibitory activity against pathogenic fungi cannot be considered without chemical characterization and identification of the compounds responsible for the inhibitory activity. JMM publishes (guest) editorials, original articles, reviews (and minireviews), case reports, technical notes, letters to the editor and information. Only clinical cases with real originality (new species, new clinical present action, new geographical localization, etc.), and fully documented (identification methods, results, etc.), will be considered. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.