{"title":"Letter to the editor - Opinion on \"Epidemiological and Microbiological aspects of Candidozyma auris (Candida auris) in Latin America: A literature review\" by Lanna et al.","authors":"Jeannete Zurita , Ruben Pardo , Gabriela Sevillano , Paulo Freire , Camilo Zurita-Salinas","doi":"10.1016/j.mycmed.2026.101611","DOIUrl":"10.1016/j.mycmed.2026.101611","url":null,"abstract":"","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 2","pages":"Article 101611"},"PeriodicalIF":1.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146135653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to \"In vitro Susceptibilities to caspofungin of Candida spp. isolated from the Polyvalent Intensive Care Unit of Fattouma Bourguiba University Hospital: First report of resistant mutants in Tunisia\" [J Mycol Med (2026) 101601].","authors":"Sameh Belgacem, Wissal Chebil, Ichrak Ferjani, Donia Ghedira, Maha Mastouri, Hamouda Babba","doi":"10.1016/j.mycmed.2026.101606","DOIUrl":"https://doi.org/10.1016/j.mycmed.2026.101606","url":null,"abstract":"","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"101606"},"PeriodicalIF":1.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soft tissue mucormycosis is a rare fungal infection that can develop on contaminated wounds. We report a case of Mucor circinelloides ankle infection in an immunocompetent man following a high-energy motorcycle accident, which has successfully been treated by surgery (multiple debridements, arthrodesis, soft tissue defect reconstruction with flap and skin graft), systemic antifungal therapy (initial liposomal amphotericin B followed by isavuconazole) and hyperbaric oxygen. This case highlights the therapeutic challenges and need for a multidisciplinary approach of such infection.
{"title":"Adjunctive hyperbaric oxygen combined with surgery and antifungal therapy for the management of soft tissue mucormycosis: a case report and review of the literature.","authors":"Pauline Kapustin, Aline Munting, Benoît Desgraz, Etienne Menager, Jérémy Brühlmann, Jocelyn Corbaz, Truong-Thanh Pham, Sylvain Meylan, Daniel Wagner, Yves Harder, Frederic Lamoth","doi":"10.1016/j.mycmed.2026.101610","DOIUrl":"https://doi.org/10.1016/j.mycmed.2026.101610","url":null,"abstract":"<p><p>Soft tissue mucormycosis is a rare fungal infection that can develop on contaminated wounds. We report a case of Mucor circinelloides ankle infection in an immunocompetent man following a high-energy motorcycle accident, which has successfully been treated by surgery (multiple debridements, arthrodesis, soft tissue defect reconstruction with flap and skin graft), systemic antifungal therapy (initial liposomal amphotericin B followed by isavuconazole) and hyperbaric oxygen. This case highlights the therapeutic challenges and need for a multidisciplinary approach of such infection.</p>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"101610"},"PeriodicalIF":1.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1016/j.mycmed.2026.101609
Rita Bitar, Philippe Blumstein, Nicolas Soetart, Pierre Cordier, Maria-Dolores Sanchez, Bienvenue Razafimandimby, Faraj Fajloun, Jean-Philippe Bouchara, Jacques Guillot, Emmanuel Bensignor
This article reports the clinical, diagnostic, and therapeutic aspects of a rare case of cutaneous and subcutaneous scedosporiosis in a 16-year-old domestic cat. The animal presented with a painful, ulcerated nodule at the base of the tail. Histopathology and fungal culture confirmed a pyogranulomatous dermatitis with hyaline hyphae, and molecular analysis identified Scedosporium sphaerospermum, a soil-dwelling fungus newly described. Despite targeted antifungal treatment with itraconazole and topical ciclopirox olamine, the cat developed systemic complications and died. This case emphasizes the challenges associated with diagnosing and managing opportunistic fungal infections in companion animals. It is, to the authors' knowledge, the first case of infection caused by S. sphaerospermum.
{"title":"Cutaneous and subcutaneous nodular scedosporiosis in a cat.","authors":"Rita Bitar, Philippe Blumstein, Nicolas Soetart, Pierre Cordier, Maria-Dolores Sanchez, Bienvenue Razafimandimby, Faraj Fajloun, Jean-Philippe Bouchara, Jacques Guillot, Emmanuel Bensignor","doi":"10.1016/j.mycmed.2026.101609","DOIUrl":"https://doi.org/10.1016/j.mycmed.2026.101609","url":null,"abstract":"<p><p>This article reports the clinical, diagnostic, and therapeutic aspects of a rare case of cutaneous and subcutaneous scedosporiosis in a 16-year-old domestic cat. The animal presented with a painful, ulcerated nodule at the base of the tail. Histopathology and fungal culture confirmed a pyogranulomatous dermatitis with hyaline hyphae, and molecular analysis identified Scedosporium sphaerospermum, a soil-dwelling fungus newly described. Despite targeted antifungal treatment with itraconazole and topical ciclopirox olamine, the cat developed systemic complications and died. This case emphasizes the challenges associated with diagnosing and managing opportunistic fungal infections in companion animals. It is, to the authors' knowledge, the first case of infection caused by S. sphaerospermum.</p>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"101609"},"PeriodicalIF":1.8,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuberculosis and systemic fungal diseases are opportunistic and challenging to diagnose. However, in immunocompromised people, especially people living with human immunodeficiency virus (PLHIV), the signs and symptoms of both diseases highly imitate each other. Primarily, chronic pulmonary aspergillosis (CPA) could have similar clinical characteristics to tuberculosis in lungs, and it is a major diagnostic challenge. Thus, the aim of the review is to analyze the prevalence, clinical manifestation, and challenges associated with the diagnostic consequences of TB and fungal infections. Although pulmonary tuberculosis (PTB) is routinely ruled out before a chronic pulmonary aspergillosis diagnosis and is widely accepted as an alternate diagnosis of CPA, the contrary is infrequent. Patients with chronic pulmonary aspergillosis usually exhibit a Th2 cytokine profile and may produce little or no IFN-γ. When fibrosis and cavitation appear on chest imaging in CPA, these patients may be misdiagnosed and neglected, which could have detrimental effects. Aspergillus-specific IgG serology is crucial for differentiating PTB and PTB relapse from CPA. Likewise, other fungal infections such as mucormycosis, cryptococcosis, histoplasmosis, and blastomycosis also reveal similar clinical manifestations to tuberculosis. Thereby, radiographic analysis is a typical diagnostic method; however, it cannot reliably detect illness symptoms. Consequently. GeneXpert can detect TB and resistance of RIF/INH in the short period, while CT imaging is better for chronic pulmonary aspergillosis and other fungal infections.
{"title":"Clinical and diagnostic misperception of tuberculosis and systemic fungal infections.","authors":"Karthikeyan Sundaram, Sridhar Rathinam, Venkataraman Prabhu","doi":"10.1016/j.mycmed.2026.101607","DOIUrl":"https://doi.org/10.1016/j.mycmed.2026.101607","url":null,"abstract":"<p><p>Tuberculosis and systemic fungal diseases are opportunistic and challenging to diagnose. However, in immunocompromised people, especially people living with human immunodeficiency virus (PLHIV), the signs and symptoms of both diseases highly imitate each other. Primarily, chronic pulmonary aspergillosis (CPA) could have similar clinical characteristics to tuberculosis in lungs, and it is a major diagnostic challenge. Thus, the aim of the review is to analyze the prevalence, clinical manifestation, and challenges associated with the diagnostic consequences of TB and fungal infections. Although pulmonary tuberculosis (PTB) is routinely ruled out before a chronic pulmonary aspergillosis diagnosis and is widely accepted as an alternate diagnosis of CPA, the contrary is infrequent. Patients with chronic pulmonary aspergillosis usually exhibit a Th2 cytokine profile and may produce little or no IFN-γ. When fibrosis and cavitation appear on chest imaging in CPA, these patients may be misdiagnosed and neglected, which could have detrimental effects. Aspergillus-specific IgG serology is crucial for differentiating PTB and PTB relapse from CPA. Likewise, other fungal infections such as mucormycosis, cryptococcosis, histoplasmosis, and blastomycosis also reveal similar clinical manifestations to tuberculosis. Thereby, radiographic analysis is a typical diagnostic method; however, it cannot reliably detect illness symptoms. Consequently. GeneXpert can detect TB and resistance of RIF/INH in the short period, while CT imaging is better for chronic pulmonary aspergillosis and other fungal infections.</p>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"101607"},"PeriodicalIF":1.8,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1016/j.mycmed.2026.101604
Imrose Wasim , Nur Shaid Mondal , Joyjeet Dey , Lunasmrita Saikia , Douglas Law , Saikat Sen , Manish Kumar Gautam , Partha Pratim Dutta
Seborrheic Dermatitis (SD) and dandruff are prevalent dermatological disorders that primarily affect the sebaceous glands and have significant implications for adults and children. While chronic skin lesions characterise SD, dandruff is characterised by excessive scalp flaking, pruritus, and erythema. Despite their overlapping clinical manifestations, these conditions differ in their underlying pathophysiology, with overgrowth of Malassezia species (spp.) emerging as a central pathogenic factor in both. Malassezia, a commensal yeast naturally residing on the skin, has been implicated in exacerbating inflammation and triggering immune responses, thereby contributing to the initiation and progression of SD and dandruff. In this comprehensive review, we systematically evaluated the role of natural and plant-derived ingredients in managing SD and dandruff, with a particular focus on their effects on Malassezia spp. The literature search was conducted using Google Scholar, Google Patents, PubMed, and SciFinder until December 2025. The extracted data were qualitatively synthesised to identify key findings and highlight existing research gaps. The results indicate that Malassezia spp., particularly Malassezia furfur, play a pivotal role in SD and dandruff by overgrowing, leading to excessive sebum production, yeast colonisation, and subsequent inflammation. M. furfur has been shown to stimulate the release of proinflammatory cytokines and activate the NLRP3 inflammasome, further promoting the inflammatory cascade associated with these conditions. Plant-derived ingredients, such as antimicrobial and anti-fungal compounds, have garnered attention for their potential therapeutic effects. Several studies suggest that substances like tea tree oil, aloe vera and various herbal extracts may reduce Malassezia load and mitigate the inflammation associated with these disorders. However, there remains a lack of clarity regarding the precise mechanisms by which these natural agents influence the skin's microbiome and immune system. Further clinical investigations are essential to assess the efficacy, safety, and optimal formulations of these plant-based treatments. Despite promising evidence supporting their use, additional well-designed studies are needed to clarify their roles and to establish standardised treatment protocols for SD and dandruff management.
{"title":"Seborrheic dermatitis and dandruff: An overview of pathogenesis, role of Malassezia spp., and natural treatment approaches","authors":"Imrose Wasim , Nur Shaid Mondal , Joyjeet Dey , Lunasmrita Saikia , Douglas Law , Saikat Sen , Manish Kumar Gautam , Partha Pratim Dutta","doi":"10.1016/j.mycmed.2026.101604","DOIUrl":"10.1016/j.mycmed.2026.101604","url":null,"abstract":"<div><div>Seborrheic Dermatitis (SD) and dandruff are prevalent dermatological disorders that primarily affect the sebaceous glands and have significant implications for adults and children. While chronic skin lesions characterise SD, dandruff is characterised by excessive scalp flaking, pruritus, and erythema. Despite their overlapping clinical manifestations, these conditions differ in their underlying pathophysiology, with overgrowth of Malassezia species (spp.) emerging as a central pathogenic factor in both. Malassezia, a commensal yeast naturally residing on the skin, has been implicated in exacerbating inflammation and triggering immune responses, thereby contributing to the initiation and progression of SD and dandruff. In this comprehensive review, we systematically evaluated the role of natural and plant-derived ingredients in managing SD and dandruff, with a particular focus on their effects on <em>Malassezia</em> spp. The literature search was conducted using Google Scholar, Google Patents, PubMed, and SciFinder until December 2025. The extracted data were qualitatively synthesised to identify key findings and highlight existing research gaps. The results indicate that <em>Malassezia</em> spp., particularly <em>Malassezia furfur</em>, play a pivotal role in SD and dandruff by overgrowing, leading to excessive sebum production, yeast colonisation, and subsequent inflammation. M. furfur has been shown to stimulate the release of proinflammatory cytokines and activate the NLRP3 inflammasome, further promoting the inflammatory cascade associated with these conditions. Plant-derived ingredients, such as antimicrobial and anti-fungal compounds, have garnered attention for their potential therapeutic effects. Several studies suggest that substances like tea tree oil, aloe vera and various herbal extracts may reduce <em>Malassezia</em> load and mitigate the inflammation associated with these disorders. However, there remains a lack of clarity regarding the precise mechanisms by which these natural agents influence the skin's microbiome and immune system. Further clinical investigations are essential to assess the efficacy, safety, and optimal formulations of these plant-based treatments. Despite promising evidence supporting their use, additional well-designed studies are needed to clarify their roles and to establish standardised treatment protocols for SD and dandruff management.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101604"},"PeriodicalIF":1.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1016/j.mycmed.2026.101605
Florian Cardona , Ferdinand Villetard , Christophe Zemmour , Evelyne D'Incan Corda , Valerio Maisano , Mariela Catalina Montes de oca , Robin Noël , Sabine Fürst , Faezeh Legrand , Djamel Mokart , Antoine Sannini , Sabine Camiade , Norbert Vey , Pierre Berger , Marie-Anne Hospital
Candidemias are increasing due to an aging and immunocompromised population. The objective of our study is to analyze survival, prognostic factors, and describe the characteristics of candidemias among onco-hematological patient. We conducted a retrospective monocentric study identifying candidemia with at least one positive yeast blood culture among patients with hematological malignancy from January, 1,2010 to December, 31, 2021. We included 135 patients. Mostly lymphoma (47%) and acute leukemia (39%) were the two major disease groups. An active disease was found in 93 patients (69%). Candida albicans (50%) was the most commonly isolated species. Mortality at 30 days after the candidemia was 44% (60/135), reaching 63% (43/68) among patients admitted to the intensive care unit. In the multivariate analysis, severe sepsis (adjusted OR 3.13; 95 % CI 1.09–9.42) and active disease (adjusted OR 4.00; 95% CI 1.41–11.33) were significantly associated with 30-day mortality while acute renal failure (adjusted OR 2.93 95% CI 0.98–8.73) was close to significance. We observed 24 breakthrough infections, with Pichia kudriavzevii being the predominant species among them. The non susceptibility rates to fluconazole and caspofungin were 15.5% (21/135) and 12% (16/135), respectively in the overall population, while reaching 54% (14/24) and 36% (8/24) in the breakthrough infection subgroup. Candidemias in onco-hematology patients are associated with significant mortality. Severe sepsis, active disease, and acute renal failure are adverse prognostic factors at 30 days. Evolving epidemiology of candidemia necessitate prospective monitoring of candidemia epidemiology to adjust prophylaxis. In case of breakthrough infection, we recommend liposomal amphotericin B or voriconazole
由于人口老龄化和免疫功能低下，念珠菌正在增加。本研究的目的是分析肿瘤血液学患者的生存、预后因素，并描述念珠菌的特征。我们进行了一项回顾性单中心研究，在2010年1月1日至2021年12月31日的血液恶性肿瘤患者中确定念珠菌至少有一个阳性酵母血培养。我们纳入了135例患者。以淋巴瘤（47%）和急性白血病（39%）为主要疾病组。93例（69%）为活动性疾病。白色念珠菌（50%）是最常见的分离种。念珠菌感染后30天死亡率为44%(60/135)，重症监护病房患者死亡率为63%（43/68）。在多因素分析中，严重脓毒症（调整OR 3.13; 95% CI 1.09-9.42）和活动性疾病（调整OR 4.00; 95% CI 1.41-11.33）与30天死亡率显著相关，而急性肾衰竭（调整OR 2.93 95% CI 0.98-8.73）与30天死亡率接近显著性。共发现突破感染24例，其中优势种为库氏毕赤酵母。总体人群对氟康唑和卡泊芬净的不易感率分别为15.5%（21/135）和12%(16/135)，突破感染亚组分别为54%（14/24）和36%（8/24）。恶性血液病患者中的念珠菌与显著的死亡率相关。严重败血症、活动性疾病和急性肾衰竭是30天的不良预后因素。随着念珠菌流行病学的不断发展，需要对念珠菌流行病学进行前瞻性监测以调整预防措施。如果出现突破性感染，我们建议使用两性霉素B脂质体或伏立康唑
{"title":"Pronostic factors for survival in candidemia among onco-hematology patients: a single-center retrospective study during 10 years","authors":"Florian Cardona , Ferdinand Villetard , Christophe Zemmour , Evelyne D'Incan Corda , Valerio Maisano , Mariela Catalina Montes de oca , Robin Noël , Sabine Fürst , Faezeh Legrand , Djamel Mokart , Antoine Sannini , Sabine Camiade , Norbert Vey , Pierre Berger , Marie-Anne Hospital","doi":"10.1016/j.mycmed.2026.101605","DOIUrl":"10.1016/j.mycmed.2026.101605","url":null,"abstract":"<div><div>Candidemias are increasing due to an aging and immunocompromised population. The objective of our study is to analyze survival, prognostic factors, and describe the characteristics of candidemias among onco-hematological patient. We conducted a retrospective monocentric study identifying candidemia with at least one positive yeast blood culture among patients with hematological malignancy from January, 1,2010 to December, 31, 2021. We included 135 patients. Mostly lymphoma (47%) and acute leukemia (39%) were the two major disease groups. An active disease was found in 93 patients (69%). <em>Candida albicans</em> (50%) was the most commonly isolated species. Mortality at 30 days after the candidemia was 44% (60/135), reaching 63% (43/68) among patients admitted to the intensive care unit. In the multivariate analysis, severe sepsis (adjusted OR 3.13; 95 % CI 1.09–9.42) and active disease (adjusted OR 4.00; 95% CI 1.41–11.33) were significantly associated with 30-day mortality while acute renal failure (adjusted OR 2.93 95% CI 0.98–8.73) was close to significance. We observed 24 breakthrough infections, with <em>Pichia kudriavzevii</em> being the predominant species among them. The non susceptibility rates to fluconazole and caspofungin were 15.5% (21/135) and 12% (16/135), respectively in the overall population, while reaching 54% (14/24) and 36% (8/24) in the breakthrough infection subgroup. Candidemias in onco-hematology patients are associated with significant mortality. Severe sepsis, active disease, and acute renal failure are adverse prognostic factors at 30 days. Evolving epidemiology of candidemia necessitate prospective monitoring of candidemia epidemiology to adjust prophylaxis. In case of breakthrough infection, we recommend liposomal amphotericin B or voriconazole</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101605"},"PeriodicalIF":1.8,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1016/j.mycmed.2026.101603
Hugo Bes-Berlandier , Jan Patrick Stellmann , Simar Berro , Bachra Choufi , Claudine Sohn , Pierre Berger , Jean Marc Schiano , Angela Granata , Faezeh Legrand , Guenièvre Imbert , Océane Marchand , Zeina Sabouni , Anthéa Deschamps , Caroline Solas , Romain Guilhaumou , Prithvi Ramtohul , Estelle Menu , Coralie L’ollivier , Stephane Ranque , Jacques Sevestre
Cryptococcus species are fungi that primarily cause infections in immunocompromised patients. In cases of hematologic malignancies, it can result in central nervous system and disseminated infections which are associated with high morbidity and case-fatality rate. We present the case of a patient with Hodgkin's lymphoma who experienced a probable relapse in disseminated cryptococcosis during the consolidation phase of treatment. After prolonged induction therapy with amphotericin B and flucytosine, followed by isavuconazole maintenance, the patient achieved a favourable outcome. Six months after relapse of cryptococcosis, the patient underwent autologous stem cell transplantation (ASCT), which resulted in sustained lymphoma remission. The cryptococcosis was successfully contained. This case highlights the need for clinicians to consider reintroducing IT in patients who experience clinical and radiological worsening during the consolidation phase. The patient demonstrated sustained clinical and radiological improvement at seven months post-ASCT, notwithstanding the presence of active cryptococcosis. This suggests that ASCT appears to be safe and feasible when the prognosis of the underlying hematological malignancy warrants its use.
{"title":"Probable disseminated cryptococcosis relapse in a patient with Hodgkin's lymphoma treated with induction therapy resumption and autologous stem cell transplant","authors":"Hugo Bes-Berlandier , Jan Patrick Stellmann , Simar Berro , Bachra Choufi , Claudine Sohn , Pierre Berger , Jean Marc Schiano , Angela Granata , Faezeh Legrand , Guenièvre Imbert , Océane Marchand , Zeina Sabouni , Anthéa Deschamps , Caroline Solas , Romain Guilhaumou , Prithvi Ramtohul , Estelle Menu , Coralie L’ollivier , Stephane Ranque , Jacques Sevestre","doi":"10.1016/j.mycmed.2026.101603","DOIUrl":"10.1016/j.mycmed.2026.101603","url":null,"abstract":"<div><div><em>Cryptococcus</em> species are fungi that primarily cause infections in immunocompromised patients. In cases of hematologic malignancies, it can result in central nervous system and disseminated infections which are associated with high morbidity and case-fatality rate. We present the case of a patient with Hodgkin's lymphoma who experienced a probable relapse in disseminated cryptococcosis during the consolidation phase of treatment. After prolonged induction therapy with amphotericin B and flucytosine, followed by isavuconazole maintenance, the patient achieved a favourable outcome. Six months after relapse of cryptococcosis, the patient underwent autologous stem cell transplantation (ASCT), which resulted in sustained lymphoma remission. The cryptococcosis was successfully contained. This case highlights the need for clinicians to consider reintroducing IT in patients who experience clinical and radiological worsening during the consolidation phase. The patient demonstrated sustained clinical and radiological improvement at seven months post-ASCT, notwithstanding the presence of active cryptococcosis. This suggests that ASCT appears to be safe and feasible when the prognosis of the underlying hematological malignancy warrants its use.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101603"},"PeriodicalIF":1.8,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Candida infections are becoming increasingly common in the Intensive Care Unit (ICU) setting representing a real threat to compromised patients. Echinocandins are considered the first-line treatment for the management of these infections. This work aimed to study the susceptibility of Candida species involved in invasive fungal infections at the ICU department of the University Hospital Fattouma Bourguiba of Monastir to caspofungin and evaluate the effect of overuse of this antifungal agent on the evolution of Minimal Inhibitory Concentrations (MICs).
Materials and methods
This study concerned 269 Candida spp. strains isolated from 152 patients of the ICU from January 2018 to May 2021. The MICs were determined according to the Clinical and Laboratory Standards Institute (CLSI) reference method. The strains categorized as resistant were sequenced at the Hot Spot (HS) region of the FKS gene. Additionally, the relationship between MICs and monthly caspofungin consumption at the ICU department was evaluated using SPSS software.
Results
Candida albicans was the most prevalent species representing 44 % (119/269), followed by C. tropicalis (52/269) and C. glabrata (51/269) (19 % each). A total of 223 isolates were subjected to susceptibility testing. Resistance to caspofungin was detected in 13 C. glabrata isolates (5.8 %). That is to say, in total, 30 % of the tested C. glabrata isolates were categorized as resistant based on their MIC values However, only one strain exhibiting a cross-resistance to anidulafungin, carried a mutation in the HS region of the FKS1 gene underscoring a discrepancy between phenotypic and genetic resistance. The evolution of MIC values was significantly correlated with caspofungin consumption for C. albicans and C. tropicalis species however non-significant for C. glabrata and the remaining species.
Conclusion
To prevent the rise of resistance to caspofungin, it is necessary to improve mycological surveillance by elaborating breakpoint values adapted to the local fungal ecology and to rationalize the prescription of this molecule.
{"title":"In vitro Susceptibilities to caspofungin of Candida spp. isolated from the Polyvalent Intensive Care Unit of Fattouma Bourguiba University Hospital: First report of resistant mutants in Tunisia","authors":"Sameh Belgacem , Wissal Chebil , Ichrak Ferjani , Donia Ghedira , Maha Mastouri , Hamouda Babba","doi":"10.1016/j.mycmed.2026.101601","DOIUrl":"10.1016/j.mycmed.2026.101601","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Candida</em> infections are becoming increasingly common in the Intensive Care Unit (ICU) setting representing a real threat to compromised patients. Echinocandins are considered the first-line treatment for the management of these infections. This work aimed to study the susceptibility of <em>Candida</em> species involved in invasive fungal infections at the ICU department of the University Hospital Fattouma Bourguiba of Monastir to caspofungin and evaluate the effect of overuse of this antifungal agent on the evolution of Minimal Inhibitory Concentrations (MICs).</div></div><div><h3>Materials and methods</h3><div>This study concerned 269 <em>Candida spp.</em> strains isolated from 152 patients of the ICU from January 2018 to May 2021. The MICs were determined according to the Clinical and Laboratory Standards Institute (CLSI) reference method. The strains categorized as resistant were sequenced at the Hot Spot (HS) region of the FKS gene. Additionally, the relationship between MICs and monthly caspofungin consumption at the ICU department was evaluated using SPSS software.</div></div><div><h3>Results</h3><div><em>Candida albicans</em> was the most prevalent species representing 44 % (119/269), followed by <em>C. tropicalis</em> (52/269) and <em>C. glabrata</em> (51/269) (19 % each). A total of 223 isolates were subjected to susceptibility testing. Resistance to caspofungin was detected in 13 <em>C. glabrata</em> isolates (5.8 %). That is to say, in total, 30 % of the tested <em>C. glabrata</em> isolates were categorized as resistant based on their MIC values However, only one strain exhibiting a cross-resistance to anidulafungin, carried a mutation in the HS region of the FKS1 gene underscoring a discrepancy between phenotypic and genetic resistance. The evolution of MIC values was significantly correlated with caspofungin consumption for <em>C. albicans</em> and <em>C. tropicalis</em> species however non-significant for <em>C. glabrata</em> and the remaining species.</div></div><div><h3>Conclusion</h3><div>To prevent the rise of resistance to caspofungin, it is necessary to improve mycological surveillance by elaborating breakpoint values adapted to the local fungal ecology and to rationalize the prescription of this molecule.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101601"},"PeriodicalIF":1.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.mycmed.2026.101600
Camille Cordier , Marie Desnos-Ollivier , Chloë Lemaire , Céline Goéminne , Jordan Leroy , Marjorie Cornu , Pauline Coulon , Séverine Loridant , Ady Assaf , Fanny Vuotto
Trichosporon spp. are ubiquitous basidiomycetous yeast-like fungi, widely distributed in the environment and commonly found in the skin and gastrointestinal microbiota. Trichosporon asahii is the most frequently implicated species in invasive trichosporonosis, usually followed by Trichosporon inkin. In recent years, the incidence of invasive fungal diseases (IFD) caused by rare yeasts of Trichosporon species has increased, predominantly affecting immunocompromised patients.
Since the late 1990s, several cases of IFD due to Trichosporon inkin sensu lato were reported in European hospitals (France, Spain and UK) in patients with history of thoracic surgery. Recently, Trichosporon austroamericanum has been identified as a new species phylogenetically related to T. inkin.
Here, we describe a fatal case of disseminated T. austroamericanum infection following heart transplantation, which was initially identified as T. inkin. Given the recent description of T. austroamericanum as a species closely related to T. inkin, we conducted a comprehensive review of all reported T. inkin sensu lato infections occurring after thoracic surgery.
{"title":"Invasive Trichosporon austroamericanum infection following heart transplantation: a case report and literature review of Trichosporon inkin sensu lato infections after thoracic surgery","authors":"Camille Cordier , Marie Desnos-Ollivier , Chloë Lemaire , Céline Goéminne , Jordan Leroy , Marjorie Cornu , Pauline Coulon , Séverine Loridant , Ady Assaf , Fanny Vuotto","doi":"10.1016/j.mycmed.2026.101600","DOIUrl":"10.1016/j.mycmed.2026.101600","url":null,"abstract":"<div><div><em>Trichosporon</em> spp. are ubiquitous basidiomycetous yeast-like fungi, widely distributed in the environment and commonly found in the skin and gastrointestinal microbiota. <em>Trichosporon asahii</em> is the most frequently implicated species in invasive trichosporonosis, usually followed by <em>Trichosporon inkin</em>. In recent years, the incidence of invasive fungal diseases (IFD) caused by rare yeasts of <em>Trichosporon</em> species has increased, predominantly affecting immunocompromised patients.</div><div>Since the late 1990s, several cases of IFD due to <em>Trichosporon inkin sensu lato</em> were reported in European hospitals (France, Spain and UK) in patients with history of thoracic surgery. Recently, <em>Trichosporon austroamericanum</em> has been identified as a new species phylogenetically related to <em>T. inkin</em>.</div><div>Here, we describe a fatal case of disseminated <em>T. austroamericanum</em> infection following heart transplantation, which was initially identified as <em>T. inkin</em>. Given the recent description of <em>T. austroamericanum</em> as a species closely related to <em>T. inkin</em>, we conducted a comprehensive review of all reported <em>T. inkin sensu lato</em> infections occurring after thoracic surgery.</div></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":"36 1","pages":"Article 101600"},"PeriodicalIF":1.8,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号