{"title":"CLASH: large-scale engineering system for the discovery of better CAR T cells","authors":"Xiaoyun Dai","doi":"10.1038/s41577-023-00908-3","DOIUrl":null,"url":null,"abstract":"In this Tools of the Trade article, Xiaoyun Dai (of the Sidi Chen lab) developed a CRISPR-based platform termed CLASH to generate a large pool of precisely gene-modified CAR T cells, from which the most desirable variants could be selected.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 9","pages":"541-541"},"PeriodicalIF":67.7000,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41577-023-00908-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In this Tools of the Trade article, Xiaoyun Dai (of the Sidi Chen lab) developed a CRISPR-based platform termed CLASH to generate a large pool of precisely gene-modified CAR T cells, from which the most desirable variants could be selected.
期刊介绍：
Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.
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