Pub Date : 2023-10-13DOI: 10.1038/s41577-023-00949-8
Yuting Ma, Guido Kroemer
Although there is little direct evidence supporting that stress affects cancer incidence, it does influence the evolution, dissemination and therapeutic outcomes of neoplasia, as shown in human epidemiological analyses and mouse models. The experience of and response to physiological and psychological stressors can trigger neurological and endocrine alterations, which subsequently influence malignant (stem) cells, stromal cells and immune cells in the tumour microenvironment, as well as systemic factors in the tumour macroenvironment. Importantly, stress-induced neuroendocrine changes that can regulate immune responses have been gradually uncovered. Numerous stress-associated immunomodulatory molecules (SAIMs) can reshape natural or therapy-induced antitumour responses by engaging their corresponding receptors on immune cells. Moreover, stress can cause systemic or local metabolic reprogramming and change the composition of the gastrointestinal microbiota which can indirectly modulate antitumour immunity. Here, we explore the complex circuitries that link stress to perturbations in the cancer-immune dialogue and their implications for therapeutic approaches to cancer. Epidemiological studies and mouse models suggest that stress can affect the evolution, dissemination and outcome of malignancies. In this Review, Ma and Kroemer present insights into the complex neuro-immune interactions that link stress to cancer, with a focus on stress-associated immunomodulatory molecules, and discuss their implications for cancer therapy.
{"title":"The cancer-immune dialogue in the context of stress","authors":"Yuting Ma, Guido Kroemer","doi":"10.1038/s41577-023-00949-8","DOIUrl":"10.1038/s41577-023-00949-8","url":null,"abstract":"Although there is little direct evidence supporting that stress affects cancer incidence, it does influence the evolution, dissemination and therapeutic outcomes of neoplasia, as shown in human epidemiological analyses and mouse models. The experience of and response to physiological and psychological stressors can trigger neurological and endocrine alterations, which subsequently influence malignant (stem) cells, stromal cells and immune cells in the tumour microenvironment, as well as systemic factors in the tumour macroenvironment. Importantly, stress-induced neuroendocrine changes that can regulate immune responses have been gradually uncovered. Numerous stress-associated immunomodulatory molecules (SAIMs) can reshape natural or therapy-induced antitumour responses by engaging their corresponding receptors on immune cells. Moreover, stress can cause systemic or local metabolic reprogramming and change the composition of the gastrointestinal microbiota which can indirectly modulate antitumour immunity. Here, we explore the complex circuitries that link stress to perturbations in the cancer-immune dialogue and their implications for therapeutic approaches to cancer. Epidemiological studies and mouse models suggest that stress can affect the evolution, dissemination and outcome of malignancies. In this Review, Ma and Kroemer present insights into the complex neuro-immune interactions that link stress to cancer, with a focus on stress-associated immunomodulatory molecules, and discuss their implications for cancer therapy.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"24 4","pages":"264-281"},"PeriodicalIF":100.3,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41206515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.1038/s41577-023-00959-6
Yvonne Bordon
Neutrophils associated with brain tumours show a more immune-suppressive and proangiogenic phenotype.
与脑肿瘤相关的中性粒细胞表现出更强的免疫抑制和促血管生成表型。
{"title":"The brain tumour microenvironment imparts neutrophils with pro-tumour properties","authors":"Yvonne Bordon","doi":"10.1038/s41577-023-00959-6","DOIUrl":"10.1038/s41577-023-00959-6","url":null,"abstract":"Neutrophils associated with brain tumours show a more immune-suppressive and proangiogenic phenotype.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 11","pages":"702-702"},"PeriodicalIF":100.3,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41206514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.1038/s41577-023-00958-7
Alexandra Flemming
A large, cross-sectional immune-profiling study provides insights into the biological features of long COVID.
一项大型横断面免疫分析研究为我们提供了有关长 COVID 生物特征的深入见解。
{"title":"The distinctive immune features of long COVID","authors":"Alexandra Flemming","doi":"10.1038/s41577-023-00958-7","DOIUrl":"10.1038/s41577-023-00958-7","url":null,"abstract":"A large, cross-sectional immune-profiling study provides insights into the biological features of long COVID.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 11","pages":"703-703"},"PeriodicalIF":100.3,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41206516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Illuminating the human yolk sac through single-cell omics","authors":"Kirsty Minton","doi":"10.1038/s41577-023-00957-8","DOIUrl":"10.1038/s41577-023-00957-8","url":null,"abstract":"A paper in Science reports a time-resolved multiomic atlas of the human yolk sac, shedding light on macrophage differentiation pathways.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 11","pages":"701-701"},"PeriodicalIF":100.3,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-06DOI: 10.1038/s41577-023-00953-y
Yvonne Bordon
{"title":"Turning on anti-tumour T cells via MTAP","authors":"Yvonne Bordon","doi":"10.1038/s41577-023-00953-y","DOIUrl":"10.1038/s41577-023-00953-y","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 11","pages":"703-703"},"PeriodicalIF":100.3,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41109213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-06DOI: 10.1038/s41577-023-00954-x
Yvonne Bordon
{"title":"Protective roles for γδ T cells in inflammatory bowel disease","authors":"Yvonne Bordon","doi":"10.1038/s41577-023-00954-x","DOIUrl":"10.1038/s41577-023-00954-x","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 11","pages":"703-703"},"PeriodicalIF":100.3,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41101222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-06DOI: 10.1038/s41577-023-00956-9
Lisa E. Wagar
In this Tools of the Trade article, Lisa Wagar (while in the Mark Davis lab) developed an in vitro immune organoid system from primary human lymphoid tissue that recapitulates productive adaptive immune responses.
在这篇《贸易工具》（Tools of the Trade）文章中，丽莎-瓦格（Lisa Wagar）（在马克-戴维斯（Mark Davis）实验室工作期间）从原生人类淋巴组织中开发出一种体外免疫类器官系统，该系统能重现富有成效的适应性免疫反应。
{"title":"Human immune organoids: a tool to study vaccine responses","authors":"Lisa E. Wagar","doi":"10.1038/s41577-023-00956-9","DOIUrl":"10.1038/s41577-023-00956-9","url":null,"abstract":"In this Tools of the Trade article, Lisa Wagar (while in the Mark Davis lab) developed an in vitro immune organoid system from primary human lymphoid tissue that recapitulates productive adaptive immune responses.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 11","pages":"699-699"},"PeriodicalIF":100.3,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-06DOI: 10.1038/s41577-023-00955-w
Lucy Bird
Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and protects against future pregnancy complications.
母鼠每次怀孕都会保留一小部分潜伏的调节性 T 细胞，这些细胞会记住它们的后代，并防止未来出现妊娠并发症。
{"title":"Daughters forget, mothers remember","authors":"Lucy Bird","doi":"10.1038/s41577-023-00955-w","DOIUrl":"10.1038/s41577-023-00955-w","url":null,"abstract":"Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and protects against future pregnancy complications.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 11","pages":"702-702"},"PeriodicalIF":100.3,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41101221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.1038/s41577-023-00942-1
Dietmar M. W. Zaiss, Edward J. Pearce, David Artis, Andrew N. J. McKenzie, Christoph S. N. Klose
Type 2 immune responses form a critical defence against enteric worm infections. In recent years, mouse models have revealed shared and unique functions for group 2 innate lymphoid cells and T helper 2 cells in type 2 immune response to intestinal helminths. Both cell types use similar innate effector functions at the site of infection, whereas each population has distinct roles during different stages of infection. In this Perspective, we review the underlying mechanisms used by group 2 innate lymphoid cells and T helper 2 cells to cooperate with each other and suggest an overarching model of the interplay between these cell types over the course of a helminth infection. In this Perspective, the authors consider the distinct contributions made by T helper 2 cells and group 2 innate lymphoid cells during the course of a helminth infection. Although anti-helminth drugs are effective, reinfection is common and there are currently no available vaccines — a better understanding of T helper 2 cell and group 2 innate lymphoid cell interplay could lead to new anti-helminth strategies.
{"title":"Cooperation of ILC2s and TH2 cells in the expulsion of intestinal helminth parasites","authors":"Dietmar M. W. Zaiss, Edward J. Pearce, David Artis, Andrew N. J. McKenzie, Christoph S. N. Klose","doi":"10.1038/s41577-023-00942-1","DOIUrl":"10.1038/s41577-023-00942-1","url":null,"abstract":"Type 2 immune responses form a critical defence against enteric worm infections. In recent years, mouse models have revealed shared and unique functions for group 2 innate lymphoid cells and T helper 2 cells in type 2 immune response to intestinal helminths. Both cell types use similar innate effector functions at the site of infection, whereas each population has distinct roles during different stages of infection. In this Perspective, we review the underlying mechanisms used by group 2 innate lymphoid cells and T helper 2 cells to cooperate with each other and suggest an overarching model of the interplay between these cell types over the course of a helminth infection. In this Perspective, the authors consider the distinct contributions made by T helper 2 cells and group 2 innate lymphoid cells during the course of a helminth infection. Although anti-helminth drugs are effective, reinfection is common and there are currently no available vaccines — a better understanding of T helper 2 cell and group 2 innate lymphoid cell interplay could lead to new anti-helminth strategies.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"24 4","pages":"294-302"},"PeriodicalIF":100.3,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41132702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：