{"title":"New Biomarkers in Anaphylaxis (Beyond Tryptase).","authors":"P Galvan-Blasco, J Gil-Serrano, A Sala-Cunill","doi":"10.1007/s40521-022-00326-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying mechanisms, effector cells, and the potential biomarkers involved depending on the anaphylaxis endotypes.</p><p><strong>Recent findings: </strong>New insight into the potential relevance of pathways others than IgE-dependent anaphylaxis has been unraveled, as well as other biomarkers than tryptase, such as the role of platelet activation factor, basogranulin, dipeptidyl peptidase I, CCL-2, and other cytokines.</p><p><strong>Summary: </strong>Gaining knowledge of all the mediators and cellular activation/communication pathways involved in each endotype of anaphylaxis will allow the application of precision medicine in patients with anaphylactic reactions, providing insights to the most appropriate approach in each case and helping to stratify severity and risk prediction.</p>","PeriodicalId":36209,"journal":{"name":"Current Treatment Options in Allergy","volume":"9 4","pages":"303-322"},"PeriodicalIF":1.9000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702867/pdf/","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Treatment Options in Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40521-022-00326-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 3
Abstract
Purpose of review: The purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying mechanisms, effector cells, and the potential biomarkers involved depending on the anaphylaxis endotypes.
Recent findings: New insight into the potential relevance of pathways others than IgE-dependent anaphylaxis has been unraveled, as well as other biomarkers than tryptase, such as the role of platelet activation factor, basogranulin, dipeptidyl peptidase I, CCL-2, and other cytokines.
Summary: Gaining knowledge of all the mediators and cellular activation/communication pathways involved in each endotype of anaphylaxis will allow the application of precision medicine in patients with anaphylactic reactions, providing insights to the most appropriate approach in each case and helping to stratify severity and risk prediction.
期刊介绍：
Current Treatment Options in Allergy will focus on the latest advances in the treatment of allergic disorders. Designed for physicians, this journal offers expert reviews on the management of skin allergies, venom allergies, rhinitis, asthma, food allergies, drug allergies, atopic dermatitis, allergy prevention, and anaphylaxis.Articles cover a range of established and emerging treatment options. We accomplish this by having experts present the latest research, assess the efficacy of available treatment options, and discuss special considerations. We ensure that the journal content includes current, emerging research and suggest articles of special interest.
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