The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not K_Ca1.1 channel expression.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-04-03 DOI:10.1080/15368378.2023.2247027

Mehmet Zülkif Akdağ, Emrah Oğraş, Züleyha Doğanyiğit, Enes Akyüz, Mahmut Berat Akdag, Aslı Okan, Veysi Akpolat, I Rem Küllü

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Abstract

The aim of this study was to understand the expression of big potassium (BK, K_Ca1.1) channels in epileptic seizures under magnetic field application. Forty Wistar albino adult male rats were divided into five groups (n = 8). First group rats were control group. Pentylenetetrazole (PTZ) administrated to second group rats to induce the seizures with 35 mg/kg intraperitoneally injection every two days. Levetiracetam (LEV) i.p. at a dose of 108 mg/kg was given to third group rats as positive control group (PC) before 20 minutes PTZ administration. Pulsed magnetic field with 1.5 mT was exposed to the fourth group rats for 3 hours a day for 1 month as magnetic field (MF) group. 1.5 mT pulsed magnetic field was exposed to the fifth group rats for 3 hours a day for 1 month in addition to PTZ administration (PTZ+MF). K_Ca1.1 not changed in hippocampus of PTZ rats while increased in frontal cortex and pons for PTZ group but not changed with magnetic field exposure. K_Ca1.1 increased in heart of PTZ animals and turned back to mean control values with magnetic field exposure. Suppressing the expected increase of c-fos protein expression in seizures with magnetic field application but not being able to change the K_Ca1.1 expression shows that new studies can be done by increasing the frequency of 1.5 mT magnetic field.

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磁场作用可抑制癫痫发作时c-fos表达的增加，但不抑制KCa1.1通道的表达。

本研究旨在了解磁场作用下癫痫发作大钾(BK, KCa1.1)通道的表达情况。40只成年雄性Wistar白化大鼠分为5组(n = 8)。第一组大鼠为对照组。第二组大鼠腹腔注射戊四唑(PTZ) 35 mg/kg，每2 d致痫。第三组大鼠在给药前20分钟给予左乙拉西坦(LEV) 108 mg/kg，作为阳性对照组(PC)。以1.5 mT的脉冲磁场照射第四组大鼠，每天照射3小时，连续1个月作为磁场组。第五组大鼠在给予PTZ (PTZ+MF)的基础上，每天照射1.5 mT脉冲磁场3小时，持续1个月。PTZ组大鼠海马区KCa1.1无变化，额叶皮质区和脑桥区KCa1.1升高，但不随磁场暴露而变化。磁场暴露后，PTZ动物心脏KCa1.1升高，并恢复到平均对照值。磁场作用抑制癫痫发作中c-fos蛋白表达的预期增加，但不能改变KCa1.1表达，表明可以通过增加1.5 mT磁场频率进行新的研究。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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