DNA repair in lung cancer: a large-scale quantitative analysis for polymorphisms in DNA repairing pathway genes and lung cancer susceptibility.

IF 2.9 3区医学 Q2 RESPIRATORY SYSTEM Expert Review of Respiratory Medicine Pub Date : 2022-09-01 DOI:10.1080/17476348.2022.2115361

Zexi Liao, Minhan Yi, Jiaxin Li, Yuan Zhang

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引用次数: 2

Abstract

Background: The results of associations between single nucleotide polymorphisms (SNPs) of genes in DNA repairing pathway and lung cancer (LC) risk are inconsistent.

Methods: We applied allele, dominant and recessive models to explore the risk of researched variants to LC in total LC and subgroups by ethnicity or LC subtypes with a cutoff point of p < 0.05.

Results: A total of 76,935 cases and 88,649 controls from 192 articles were included. Among the analyzed 40 variants from 20 genes, we found 9 statistically significant variants in overall populations by allele model, including five SNPs (rs1760944, rs9344, rs13181, rs1001581, and rs915927) increasing LC risk (odd ratios [ORs] = 1.10-1.71) and four SNPs (rs1042522, rs3213245, rs11615, and rs238406) decreasing the risk (ORs = 0.75-0.94). We identified rs1042522 and rs13181 as significant variants for LC in three models. Additionally, we identified differential significant SNPs in ethnic and subtype's analysis with comparison to total population.

Conclusions: There are five SNPs in DNA repairing pathway associated with increased LC risk and four others decreased LC risk. Besides, the risky SNPs in different ethnicities and various LC subtypes were partly different, and the contribution of different genotypes to risk alleles were various as well.

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肺癌DNA修复:DNA修复通路基因多态性与肺癌易感性的大规模定量分析

背景:DNA修复通路基因单核苷酸多态性(snp)与肺癌(LC)发病风险的相关性研究结果并不一致。方法:采用等位基因、显性和隐性模型，以种族或亚型为截断点，以p为截断点，在LC总和亚组中探讨研究变异对LC的风险。结果:共纳入来自192篇文章的76,935例病例和88,649例对照。在分析的来自20个基因的40个变异中，我们通过等位基因模型发现9个变异在整体人群中具有统计学意义，其中5个snp (rs1760944、rs9344、rs13181、rs1001581和rs915927)增加了LC风险(奇数比[or] = 1.10-1.71)， 4个snp (rs1042522、rs3213245、rs11615和rs238406)降低了LC风险(or = 0.75-0.94)。我们发现rs1042522和rs13181是三种模型中LC的重要变体。此外，与总人口相比，我们在种族和亚型分析中发现了显著差异的snp。结论:DNA修复通路中有5个snp与LC风险增加相关，另外4个snp与LC风险降低相关。此外，不同种族和不同LC亚型的风险snp存在部分差异，不同基因型对风险等位基因的贡献也存在差异。

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来源期刊

Expert Review of Respiratory Medicine RESPIRATORY SYSTEM-

CiteScore

6.80

自引率

2.60%

发文量

期刊介绍： Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity

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