INTRODUCTIONLymphangioleiomyomatosis (LAM) is a rare and progressive disorder that usually arises in the lung and almost exclusively affects women of childbearing age. In recent years, a number of molecules have been shown to be differentially expressed between patients with LAM and healthy control individuals, and some of these molecules, in addition to vascular endothelial growth factor D (VEGF-D), have the potential to be novel biomarkers.AREAS COVEREDThis review summarizes the recent advances in omics research, including genomics, transcriptomics, proteomics, and metabolomics, in LAM biomarker discovery. It also retrieves the literature on LAM biomarkers studied by omics techniques in the last ten years using PubMed and other retrieval tools.EXPERT OPINIONFurther research on expanded sample sizes can be conducted to construct specific models to study the role of these molecules in the pathogenesis of LAM and clarify the underlying mechanisms involved. In the future, in terms of technology, the combination of various omics methods is expected to result in novel biomarker discovery.
导言淋巴管瘤（LAM）是一种罕见的进行性疾病，通常发生在肺部，几乎只影响育龄妇女。近年来，一些分子被证明在 LAM 患者和健康对照者之间有差异表达，其中一些分子，除了血管内皮生长因子 D (VEGF-D)，还有可能成为新型生物标记物。专家观点可以通过扩大样本量开展进一步研究，构建特定模型来研究这些分子在 LAM 发病机制中的作用，并阐明相关的潜在机制。未来，在技术方面，各种 omics 方法的结合有望发现新的生物标记物。
{"title":"Omics research in lymphangioleiomyomatosis: status and challenges.","authors":"Xinhe Zhang,Song Liu,Luning Yang,Chongsheng Cheng,Hanghang Wang,Danjing Hu,Xiaoxin Zhang,Miaoyan Zhang,Yaping Liu,Xinlun Tian,Hongbing Zhang,Kai-Feng Xu","doi":"10.1080/17476348.2024.2403498","DOIUrl":"https://doi.org/10.1080/17476348.2024.2403498","url":null,"abstract":"INTRODUCTIONLymphangioleiomyomatosis (LAM) is a rare and progressive disorder that usually arises in the lung and almost exclusively affects women of childbearing age. In recent years, a number of molecules have been shown to be differentially expressed between patients with LAM and healthy control individuals, and some of these molecules, in addition to vascular endothelial growth factor D (VEGF-D), have the potential to be novel biomarkers.AREAS COVEREDThis review summarizes the recent advances in omics research, including genomics, transcriptomics, proteomics, and metabolomics, in LAM biomarker discovery. It also retrieves the literature on LAM biomarkers studied by omics techniques in the last ten years using PubMed and other retrieval tools.EXPERT OPINIONFurther research on expanded sample sizes can be conducted to construct specific models to study the role of these molecules in the pathogenesis of LAM and clarify the underlying mechanisms involved. In the future, in terms of technology, the combination of various omics methods is expected to result in novel biomarker discovery.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-11DOI: 10.1080/17476348.2024.2403500
Mahmoud Abu Zahra,Jeffrey Pessin,Deepa Rastogi
INTRODUCTIONObesity, one of the most common chronic conditions affecting the human race globally, affects several organ systems, including the respiratory system, where it contributes to onset and high burden of asthma. Childhood onset of obesity-related asthma is associated with high persistent morbidity into adulthood.AREAS COVEREDIn this review, we discuss the disease burden in children and adults to highlight the overlap between symptoms and pulmonary function deficits associated with obesity-related asthma in both age ranges, and then discuss the potential role of three distinct mechanisms, that of mechanical fat load, immune perturbations, and of metabolic perturbations on the disease burden. We also discuss interventions, including medical interventions for weight loss such as diet modification, that of antibiotics and anti-inflammatory therapies, as well as that of surgical intervention on amelioration of burden of obesity-related asthma.EXPERT OPINIONWith increase in obesity-related asthma due to increasing burden of obesity, it is evident that it is a disease entity distinct from asthma among lean individuals. The time is ripe to investigate the underlying mechanisms, focusing on identifying novel therapeutic targets as well as consideration to repurpose medications effective for other obesity-mediated complications, such as insulin resistance, dyslipidemia and systemic inflammation.
{"title":"A clinician's guide to effects of obesity on childhood asthma and into adulthood.","authors":"Mahmoud Abu Zahra,Jeffrey Pessin,Deepa Rastogi","doi":"10.1080/17476348.2024.2403500","DOIUrl":"https://doi.org/10.1080/17476348.2024.2403500","url":null,"abstract":"INTRODUCTIONObesity, one of the most common chronic conditions affecting the human race globally, affects several organ systems, including the respiratory system, where it contributes to onset and high burden of asthma. Childhood onset of obesity-related asthma is associated with high persistent morbidity into adulthood.AREAS COVEREDIn this review, we discuss the disease burden in children and adults to highlight the overlap between symptoms and pulmonary function deficits associated with obesity-related asthma in both age ranges, and then discuss the potential role of three distinct mechanisms, that of mechanical fat load, immune perturbations, and of metabolic perturbations on the disease burden. We also discuss interventions, including medical interventions for weight loss such as diet modification, that of antibiotics and anti-inflammatory therapies, as well as that of surgical intervention on amelioration of burden of obesity-related asthma.EXPERT OPINIONWith increase in obesity-related asthma due to increasing burden of obesity, it is evident that it is a disease entity distinct from asthma among lean individuals. The time is ripe to investigate the underlying mechanisms, focusing on identifying novel therapeutic targets as well as consideration to repurpose medications effective for other obesity-mediated complications, such as insulin resistance, dyslipidemia and systemic inflammation.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-03DOI: 10.1080/17476348.2024.2387785
Maged Hassan, Sally Griffiths, Ben Probyn, Ahmed S Sadaka, Abdelfattah A Touman, Gareth Trevelyan, David Breen, Cyrus Daneshvar
Theuse of ultrasound in respiratory disease has evolved substantially over thepast two decades. From a test done to confirm the safe site of pleural fluiddrainage, thoracic ultrasound has become a ...
{"title":"Thoracic ultrasound in guiding management of respiratory disease","authors":"Maged Hassan, Sally Griffiths, Ben Probyn, Ahmed S Sadaka, Abdelfattah A Touman, Gareth Trevelyan, David Breen, Cyrus Daneshvar","doi":"10.1080/17476348.2024.2387785","DOIUrl":"https://doi.org/10.1080/17476348.2024.2387785","url":null,"abstract":"Theuse of ultrasound in respiratory disease has evolved substantially over thepast two decades. From a test done to confirm the safe site of pleural fluiddrainage, thoracic ultrasound has become a ...","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141880486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-22DOI: 10.1080/17476348.2024.2345684
Jyotirmayee Lenka, Raymond Foley, Mark Metersky, Adrian Salmon
Obstructive sleep apnea (OSA) is a widely prevalent condition with consequent multiple organ systems complications. There is consensus that OSA is associated with negative effects on pulmonary hemo...
{"title":"Relationship between obstructive sleep apnea and pulmonary hypertension: past, present and future","authors":"Jyotirmayee Lenka, Raymond Foley, Mark Metersky, Adrian Salmon","doi":"10.1080/17476348.2024.2345684","DOIUrl":"https://doi.org/10.1080/17476348.2024.2345684","url":null,"abstract":"Obstructive sleep apnea (OSA) is a widely prevalent condition with consequent multiple organ systems complications. There is consensus that OSA is associated with negative effects on pulmonary hemo...","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140636881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.1080/17476348.2024.2323189
Michelle Casey, Nicholas J Simmonds
Published in Expert Review of Respiratory Medicine (Just accepted, 2024)
发表于《呼吸医学专家评论》（刚刚接受，2024 年）
{"title":"Why don’t anti-inflammatories work in cystic fibrosis?","authors":"Michelle Casey, Nicholas J Simmonds","doi":"10.1080/17476348.2024.2323189","DOIUrl":"https://doi.org/10.1080/17476348.2024.2323189","url":null,"abstract":"Published in Expert Review of Respiratory Medicine (Just accepted, 2024)","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139921823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-05DOI: 10.1080/17476348.2024.2314535
Lingling Wang, Ling zhou, Pengdou Zheng, Zhenyu Mao, Huiguo Liu
Asthma is a common chronic respiratory disease characterized by chronic airway inflammation, airway hyperresponsiveness, reversible airflow limitation, and airway remodeling. Mild asthma is the mos...
{"title":"Mild asthma is not mild: Risk factors and predictive biomarkers for severe acute exacerbations and progression in mild asthma","authors":"Lingling Wang, Ling zhou, Pengdou Zheng, Zhenyu Mao, Huiguo Liu","doi":"10.1080/17476348.2024.2314535","DOIUrl":"https://doi.org/10.1080/17476348.2024.2314535","url":null,"abstract":"Asthma is a common chronic respiratory disease characterized by chronic airway inflammation, airway hyperresponsiveness, reversible airflow limitation, and airway remodeling. Mild asthma is the mos...","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139689331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-19DOI: 10.1080/17476348.2023.2295941
Anita Saigal, Amar J Shah, Swapna Mandal
Home noninvasive ventilation (HNIV) has expanded globally, with a greater evidence base for its’ use. HNIV improves multiple patient related outcomes in patients with chronic hypercapnic respirator...
{"title":"Indications and evidence for domiciliary noninvasive ventilation","authors":"Anita Saigal, Amar J Shah, Swapna Mandal","doi":"10.1080/17476348.2023.2295941","DOIUrl":"https://doi.org/10.1080/17476348.2023.2295941","url":null,"abstract":"Home noninvasive ventilation (HNIV) has expanded globally, with a greater evidence base for its’ use. HNIV improves multiple patient related outcomes in patients with chronic hypercapnic respirator...","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138818448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-12DOI: 10.1080/17476348.2023.2282022
Bi Ran, Yutian Zhang, Yanqiu Wu, Fuqiang Wen
Observational studies showed a bidirectional association between depression and chronic obstructive pulmonary disease (COPD). However, it is unclear whether the observed association is causal. Thus...
{"title":"Association between depression and COPD: results from the NHANES 2013–2018 and a bidirectional Mendelian randomization analysis","authors":"Bi Ran, Yutian Zhang, Yanqiu Wu, Fuqiang Wen","doi":"10.1080/17476348.2023.2282022","DOIUrl":"https://doi.org/10.1080/17476348.2023.2282022","url":null,"abstract":"Observational studies showed a bidirectional association between depression and chronic obstructive pulmonary disease (COPD). However, it is unclear whether the observed association is causal. Thus...","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138576484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-12DOI: 10.1080/17476348.2023.2294927
Xiaohua Li, Bin Dai, Qingbing Han, Yanqiu Wu, Bi Ran, Tao Wang, Fuqiang Wen, Jun Chen
Despite potential benefits and widespread prescription of aspirin among chronic obstructive pulmonary disease (COPD) patients, limited research has investigated its adverse effects in COPD populati...
{"title":"High risks adverse events associated with usage of aspirin in chronic obstructive pulmonary disease","authors":"Xiaohua Li, Bin Dai, Qingbing Han, Yanqiu Wu, Bi Ran, Tao Wang, Fuqiang Wen, Jun Chen","doi":"10.1080/17476348.2023.2294927","DOIUrl":"https://doi.org/10.1080/17476348.2023.2294927","url":null,"abstract":"Despite potential benefits and widespread prescription of aspirin among chronic obstructive pulmonary disease (COPD) patients, limited research has investigated its adverse effects in COPD populati...","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138681062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
. Long-COVID-19 patients (LC19Ps) often experience cardiovascular and respiratory complications. Cardiorespiratory rehabilitation programs (CRRPs) have emerged as promising interventions to enhance...
{"title":"Effects of cardiorespiratory rehabilitation program on submaximal exercise in patients with long-COVID-19 conditions: a systematic review of randomized controlled trials and recommendations for future studies","authors":"Amine Ghram, Imed Latiri, Jabeur Methnani, Amine Souissi, Wafa Benzarti, Emna Toulgui, Helmi Ben Saad","doi":"10.1080/17476348.2023.2293226","DOIUrl":"https://doi.org/10.1080/17476348.2023.2293226","url":null,"abstract":". Long-COVID-19 patients (LC19Ps) often experience cardiovascular and respiratory complications. Cardiorespiratory rehabilitation programs (CRRPs) have emerged as promising interventions to enhance...","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138576738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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