Adrenocorticotropic hormone (ACTH) level and adrenal deficiency in patients with mucocutaneous pemphigus.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI:10.1515/hmbci-2021-0097

Mohammadreza Salehi, Zabihollah Shahmoradi, Seyed Mohammad Razavi, Iraj Lali, Elham Faghihian

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Abstract

Objectives: This study aimed to evaluate the level of adrenocorticotropic hormone (ACTH) and adrenal insufficiency in patients with mucocutaneous pemphigus lesions who use oral corticosteroids.

Methods: This descriptive-analytical study was performed on 54 patients (48.44 ± 12.74 years) with mucocutaneous pemphigus in 2019. Those patients taken corticosteroids in different doses and way. At first, collected patients information including age, sex, type of pemphigus, duration of use, patient dosage, duration of corticosteroid administration, and method of administration were collected daily. Adrenal gland function was measured by evaluating ACTH levels. Data were analyzed by using Pearson correlation coefficient and t-test.

Results: Our study showed that 37 cases (68.5%) had normal ACTH average hormone level (7.3-63.3 mL/pg), 11 cases (20.4%) were lower levels (<7.2 mL/pg), and 6 cases (11.1%) were higher levels (63.3 > mL/pg). Wo observed no significant relationship between ACTH and duration of corticosteroids usage (p=0.207).

Conclusions: Taking a maintenance dose of between 12.5 and 25 mg daily does not usually lead to adrenal insufficiency. The present study showed that the lower the daily dose of corticosteroids, the lower the likelihood of adrenal insufficiency.

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促肾上腺皮质激素(ACTH)水平与皮肤粘膜性天疱疮患者肾上腺缺乏的关系。

目的:本研究旨在评估口服糖皮质激素的皮肤粘膜天疱疮患者促肾上腺皮质激素(ACTH)水平和肾上腺功能不全。方法:对2019年54例(48.44±12.74岁)皮肤粘膜天疱疮患者进行描述性分析研究。这些患者以不同的剂量和方式服用皮质类固醇。首先，每天收集患者的年龄、性别、天疱疮类型、使用时间、患者剂量、皮质类固醇给药时间和给药方法等信息。通过ACTH水平测定肾上腺功能。数据分析采用Pearson相关系数和t检验。结果:37例(68.5%)ACTH平均激素水平正常(7.3 ~ 63.3 mL/pg)， 11例(20.4%)ACTH平均激素水平较低(mL/pg)。我们观察到ACTH与皮质类固醇使用时间无显著关系(p=0.207)。结论:每天服用12.5 - 25mg维持剂量通常不会导致肾上腺功能不全。目前的研究表明，皮质类固醇的日剂量越低，肾上腺功能不全的可能性越低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

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期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.