Pheromone Response and Mating Behavior in Fission Yeast.

IF 8 1区 生物学 Q1 MICROBIOLOGY Microbiology and Molecular Biology Reviews Pub Date : 2022-12-21 Epub Date: 2022-12-05 DOI:10.1128/mmbr.00130-22
Taisuke Seike, Hironori Niki
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Abstract

Most ascomycete fungi, including the fission yeast Schizosaccharomyces pombe, secrete two peptidyl mating pheromones: C-terminally modified and unmodified peptides. S. pombe has two mating types, plus and minus, which secrete two different pheromones, P-factor (unmodified) and M-factor (modified), respectively. These pheromones are specifically recognized by receptors on the cell surface of cells of opposite mating types, which trigger a pheromone response. Recognition between pheromones and their corresponding receptors is important for mate discrimination; therefore, genetic changes in pheromone or receptor genes affect mate recognition and cause reproductive isolation that limits gene flow between populations. Such genetic variation in recognition via the pheromone/receptor system may drive speciation. Our recent studies reported that two pheromone receptors in S. pombe might have different stringencies in pheromone recognition. In this review, we focus on the molecular mechanism of pheromone response and mating behavior, emphasizing pheromone diversification and its impact on reproductive isolation in S. pombe and closely related fission yeast species. We speculate that the "asymmetric" system might allow flexible adaptation to pheromone mutational changes while maintaining stringent recognition of mating partners. The loss of pheromone activity results in the extinction of an organism's lineage. Therefore, genetic changes in pheromones and their receptors may occur gradually and/or coincidently before speciation. Our findings suggest that the M-factor plays an important role in partner discrimination, whereas P-factor communication allows flexible adaptation to create variations in S. pombe. Our inferences provide new insights into the evolutionary mechanisms underlying pheromone diversification.

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裂变酵母的信息素反应和交配行为。
大多数子囊菌真菌,包括分裂酵母裂糖菌,分泌两种肽基交配信息素:c端修饰肽和未修饰肽。pombe有正负两种交配类型,分别分泌p因子(未修饰)和m因子(修饰)两种不同的信息素。这些信息素被相反交配类型的细胞表面的受体特异性识别,从而触发信息素反应。信息素与其相应受体之间的识别对配偶识别很重要;因此,信息素或受体基因的遗传变化影响配偶识别,并导致生殖隔离,限制了种群之间的基因流动。这种通过信息素/受体系统识别的遗传变异可能驱动物种形成。我们最近的研究报道了pombe中两种信息素受体在信息素识别方面可能有不同的强度。本文综述了信息素反应和交配行为的分子机制,重点介绍了信息素多样化及其对S. pombe和近缘裂变酵母物种生殖隔离的影响。我们推测,“不对称”系统可能允许灵活适应信息素突变变化,同时保持对交配伙伴的严格识别。信息素活性的丧失导致生物体谱系的灭绝。因此,信息素及其受体的遗传变化可能在物种形成之前逐渐和/或巧合地发生。我们的研究结果表明,m因子在伴侣歧视中起着重要作用,而p因子交流允许灵活的适应来创造S. pombe的变化。我们的推论为信息素多样化的进化机制提供了新的见解。
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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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