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STRIPAK, a fundamental signaling hub of eukaryotic development. STRIPAK,真核生物发育的基本信号枢纽。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-11-11 DOI: 10.1128/mmbr.00205-23
Ulrich Kück, Stefanie Pöggeler

SUMMARYThe striatin-interacting phosphatase and kinase (STRIPAK) complex is involved in the regulation of many developmental processes in eukaryotic microorganisms and all animals, including humans. STRIPAK is a component of protein phosphatase 2A (PP2A), a highly conserved serine-threonine phosphatase composed of catalytic subunits (PP2Ac), a scaffolding subunit (PP2AA) and various substrate-directing B regulatory subunits. In particular, the B''' regulatory subunit called striatin has evoked major interest over the last 20 years. Studies in fungal systems have contributed substantially to our current knowledge about STRIPAK composition, assembly, and cellular localization, as well as its regulatory role in autophagy and the morphology of fungal development. STRIPAK represents a signaling hub with many kinases and thus integrates upstream and downstream information from many conserved eukaryotic signaling pathways. A profound understanding of STRIPAK's regulatory role in fungi opens the gateway to understanding the multifarious functions carried out by STRIPAK in higher eukaryotes, including its contribution to malignant cell growth.

摘要纹蛋白互作磷酸酶和激酶(STRIPAK)复合物参与真核微生物和包括人类在内的所有动物的许多发育过程的调控。STRIPAK 是蛋白磷酸酶 2A(PP2A)的一个组成部分,PP2A 是一种高度保守的丝氨酸-苏氨酸磷酸酶,由催化亚基(PP2Ac)、支架亚基(PP2AA)和各种底物导向 B 调节亚基组成。其中,被称为纹蛋白的 B'''调控亚基在过去 20 年中引起了人们的极大兴趣。对真菌系统的研究极大地促进了我们对 STRIPAK 的组成、组装、细胞定位及其在自噬和真菌发育形态中的调控作用的了解。STRIPAK 是一个信号枢纽,有许多激酶,因此整合了来自许多保守的真核生物信号通路的上游和下游信息。深入了解 STRIPAK 在真菌中的调控作用,为了解 STRIPAK 在高等真核生物中的多种功能(包括其对恶性细胞生长的贡献)打开了大门。
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引用次数: 0
Threats from the Candida parapsilosis complex: the surge of multidrug resistance and a hotbed for new emerging pathogens. 来自副丝状念珠菌复合体的威胁:多重耐药性的激增和新出现病原体的温床。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-11-07 DOI: 10.1128/mmbr.00029-23
Toni Gabaldón

SUMMARYCandida parapsilosis is a common agent of candidiasis that has gained increased attention in recent years, culminating with its recent consideration as a high-priority fungal pathogen by the World Health Organization. Reasons for this classification are the recent surge in incidence and the alarmingly growing rates of drug and multidrug resistance. In addition, several closely related species such as Candida metapsilosis and Candida orthopsilosis may represent recently emerged opportunistic pathogens originated from environmental niches through interspecies hybridization. Here, I review recent research focused on the potential origin and spread of drug resistance and of emerging species in this complex. I will also discuss open questions regarding the possible implications of human activities in these two epidemiological phenomena.

摘要副丝状念珠菌是念珠菌病的一种常见病原体,近年来日益受到关注,世界卫生组织最近将其列为高度优先的真菌病原体。之所以将其列为高度优先真菌病原体,是因为其发病率近来急剧上升,而且耐药性和多重耐药性的比率也在惊人地增长。此外,几种密切相关的菌种,如甲硅质念珠菌和正硅质念珠菌,可能是最近出现的机会性病原体,通过种间杂交起源于环境壁龛。在此,我将回顾最近的研究,重点是这一复合体中耐药性和新出现物种的潜在起源和传播。我还将讨论人类活动在这两种流行病学现象中可能产生的影响。
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引用次数: 0
Bacterial acquisition of host fatty acids has far-reaching implications on virulence. 细菌获取宿主脂肪酸对毒力有深远影响。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-10-30 DOI: 10.1128/mmbr.00126-24
Jack K Waters, Bart A Eijkelkamp

SUMMARYThe lipid homeostasis pathways of bacterial pathogens have been studied comprehensively for their biochemical functionality. However, new and refined technologies have supported the interrogation of bacterial lipid and fatty acid homeostasis mechanisms in more complex environments, such as mammalian host niches. In particular, emerging findings on the breadth and depth of host fatty acid uptake have demonstrated their importance beyond merely fatty acid utilization for membrane synthesis, as they can contribute to virulence factor regulation, pathogenesis, and group-based behaviors. Lipid homeostasis is also intertwined with other metabolic and physiological processes in the bacterial cells, which appear to be largely unique per species, but overarching themes can be derived. This review combines the latest biochemical and structural findings and places these in the context of bacterial pathogenesis, thereby shedding light on the far-reaching implications of lipid homeostasis on bacterial success.

摘要 细菌病原体的脂质平衡途径已被全面研究,以了解其生化功能。然而,新的精炼技术支持了对细菌在哺乳动物宿主龛位等更复杂环境中的脂质和脂肪酸平衡机制的研究。特别是,关于宿主脂肪酸摄取的广度和深度的新发现表明,脂肪酸的重要性不仅限于利用脂肪酸进行膜合成,它们还有助于毒力因子调节、致病机理和群体行为。脂质平衡还与细菌细胞中的其他代谢和生理过程交织在一起,这些过程似乎在很大程度上因物种而异,但也可以从中得出一些总体性的主题。这篇综述结合了最新的生化和结构研究成果,并将其置于细菌致病机理的背景下,从而揭示了脂质平衡对细菌成功的深远影响。
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引用次数: 0
Hepatitis B virus entry, assembly, and egress. 乙型肝炎病毒的进入、聚集和排出。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-10-23 DOI: 10.1128/mmbr.00014-24
Yu-Chen Chuang, J-H James Ou

SUMMARYHepatitis B virus (HBV) is an important human pathogen that chronically infects approximately 250 million people in the world, resulting in ~1 million deaths annually. This virus is a hepatotropic virus and can cause severe liver diseases including cirrhosis and hepatocellular carcinoma. The entry of HBV into hepatocytes is initiated by the interaction of its envelope proteins with its receptors. This is followed by the delivery of the viral nucleocapsid to the nucleus for the release of its genomic DNA and the transcription of viral RNAs. The assembly of the viral capsid particles may then take place in the nucleus or the cytoplasm and may involve cellular membranes. This is followed by the egress of the virus from infected cells. In recent years, significant research progresses had been made toward understanding the entry, the assembly, and the egress of HBV particles. In this review, we discuss the molecular pathways of these processes and compare them with those used by hepatitis delta virus and hepatitis C virus , two other hepatotropic viruses that are also enveloped. The understanding of these processes will help us to understand how HBV replicates and causes diseases, which will help to improve the treatments for HBV patients.

摘要乙型肝炎病毒(HBV)是一种重要的人类病原体,全世界约有 2.5 亿人长期感染该病毒,每年约有 100 万人因此死亡。该病毒是一种致肝病毒,可导致严重的肝脏疾病,包括肝硬化和肝细胞癌。HBV 进入肝细胞是由其包膜蛋白与其受体相互作用开始的。随后,病毒核壳被送入细胞核,释放其基因组 DNA 并转录病毒 RNA。然后,病毒衣壳颗粒可能在细胞核或细胞质中组装,也可能涉及细胞膜。随后,病毒从受感染的细胞中排出。近年来,人们在了解 HBV 颗粒的进入、组装和排出方面取得了重大研究进展。在这篇综述中,我们将讨论这些过程的分子途径,并将它们与其他两种同样具有包膜的肝毒性病毒--乙型肝炎病毒和丙型肝炎病毒--的分子途径进行比较。了解这些过程将有助于我们理解 HBV 如何复制和致病,从而有助于改进对 HBV 患者的治疗。
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引用次数: 0
Urinary tract infections and catheter-associated urinary tract infections caused by Pseudomonas aeruginosa. 铜绿假单胞菌引起的尿路感染和导尿管相关性尿路感染。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-10-21 DOI: 10.1128/mmbr.00066-22
Nour El Husseini, Jared A Carter, Vincent T Lee

SUMMARYUrinary tract infection (UTI) is one of the most common infections in otherwise healthy individuals. UTI is also common in healthcare settings where patients often require urinary catheters to alleviate urinary retention. The placement of a urinary catheter often leads to catheter-associated urinary tract infection (CAUTI) caused by a broad range of opportunistic pathogens, commonly referred to as ESKAPE (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter) pathogens. Our understanding of CAUTI is complicated by the differences in pathogens, in initial microbial load, changes that occur due to the duration of catheterization, and the relationship between infection (colonization) and disease symptoms. To advance our understanding of CAUTI, we reviewed UTI and CAUTI caused by Pseudomonas aeruginosa which is unique in that it is not commonly found associated with human microbiomes. For this reason, the ability of P. aeruginosa to cause UTI and CAUTI requires the introduction of the bacteria to the bladder from catheterization. Once in the host, the virulence factors used by P. aeruginosa in these infections remain an area of ongoing research. In this review, we will discuss studies that focus on P. aeruginosa UTI and CAUTI to better understand the infection dynamics and outcome in clinical settings, virulence factors associated with P. aeruginosa isolated from the urinary tract, and animal studies to test which bacterial factors are required for this infection. Understanding how P. aeruginosa can cause UTI and CAUTI can provide an understanding of how these infections initiate and progress and may provide possible strategies to limit these infections.

摘要尿路感染(UTI)是健康人最常见的感染之一。尿路感染在医疗机构中也很常见,因为病人通常需要使用导尿管来缓解尿潴留。导尿管的放置通常会导致导尿管相关性尿路感染(CAUTI),由多种机会性病原体引起,这些病原体通常被称为 ESKAPE(肠球菌、葡萄球菌、克雷伯氏菌、不动杆菌、假单胞菌和肠杆菌)病原体。我们对 CAUTI 的了解因病原体、初始微生物负荷、导管插入时间的变化以及感染(定植)和疾病症状之间的关系而变得复杂。为了加深对 CAUTI 的了解,我们回顾了由铜绿假单胞菌引起的 UTI 和 CAUTI。因此,铜绿假单胞菌引起尿道炎和膀胱炎需要通过导尿将细菌引入膀胱。一旦进入宿主体内,铜绿假单胞菌在这些感染中使用的毒力因子仍是一个持续研究的领域。在本综述中,我们将讨论以铜绿假单胞菌UTI和CAUTI为重点的研究,以便更好地了解临床环境中的感染动态和结果、从泌尿道分离出的铜绿假单胞菌的相关毒力因子,以及测试这种感染需要哪些细菌因子的动物研究。了解铜绿假单胞菌如何引起UTI和CAUTI,就能了解这些感染是如何开始和发展的,并为限制这些感染提供可能的策略。
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引用次数: 0
Adaptations and metabolic evolution of myzozoan protists across diverse lifestyles and environments. 不同生活方式和环境下的贻贝原生动物的适应性和新陈代谢进化。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-10-10 DOI: 10.1128/mmbr.00197-22
Ross F Waller, Vern B Carruthers

SUMMARYMyzozoans encompass apicomplexans and dinoflagellates that manifest diverse lifestyles in highly varied environments. They show enormous propensity to employ different metabolic programs and exploit different nutrient resources and niches, and yet, they share much core biology that underlies this evolutionary success and impact. This review discusses apicomplexan parasites of medical significance and the traits and properties they share with non-pathogenic myzozoans. These include the versatility of myzozoan plastids, which scale from fully photosynthetic organelles to the site of very select key metabolic pathways. Pivotal evolutionary innovations, such as the apical complex, have allowed myzozoans to shift from predatory to parasitic and other symbiotic lifestyles multiple times in both apicomplexan and dinoflagellate branches of the myzozoan evolutionary tree. Such traits, along with shared mechanisms for nutrient acquisition, appear to underpin the prosperity of myzozoans in their varied habitats. Understanding the mechanisms of these shared traits has the potential to spawn new strategic interventions against medically and veterinary relevant parasites within this grouping.

摘要贻贝纲包括类囊体和甲藻,它们在千差万别的环境中表现出多种多样的生活方式。它们在采用不同的新陈代谢程序、利用不同的营养资源和生态位方面表现出巨大的倾向性,然而,它们在许多核心生物学方面却具有共通性,而这些共通性正是它们在进化过程中取得成功并产生影响的基础。这篇综述讨论了具有重要医学意义的类囊体寄生虫,以及它们与非致病性的粘虫共有的特征和特性。这些特性包括:拟水螅质体的多功能性,从完全的光合细胞器到非常精选的关键代谢途径。顶端复合体等关键性的进化创新,使无尾纲动物在无尾纲动物进化树的无尾复合体分支和甲藻分支中多次从捕食生活方式转变为寄生生活方式和其他共生生活方式。这些特征以及共同的营养获取机制,似乎是它们在不同的栖息地中繁衍生息的基础。了解这些共同特征的机理,有可能产生新的战略干预措施,以对付这个类群中与医学和兽医学有关的寄生虫。
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引用次数: 0
The multifaceted roles of phosphoethanolamine-modified lipopolysaccharides: from stress response and virulence to cationic antimicrobial resistance. 磷脂酰乙醇胺修饰的脂多糖的多方面作用:从应激反应和毒力到阳离子抗菌性。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-10-09 DOI: 10.1128/mmbr.00193-23
Anna Schumann, Ahmed Gaballa, Martin Wiedmann

SUMMARYLipopolysaccharides (LPS) are an integral part of the outer membrane of Gram-negative bacteria and play essential structural and functional roles in maintaining membrane integrity as well as in stress response and virulence. LPS comprises a membrane-anchored lipid A group, a sugar-based core region, and an O-antigen formed by repeating oligosaccharide units. 3-Deoxy-D-manno-octulosonic acid-lipid A (Kdo2-lipid A) is the minimum LPS component required for bacterial survival. While LPS modifications are not essential, they play multifaceted roles in stress response and host-pathogen interactions. Gram-negative bacteria encode several distinct LPS-modifying phosphoethanolamine transferases (PET) that add phosphoethanolamine (pEtN) to lipid A or the core region of LPS. The pet genes differ in their genomic locations, regulation mechanisms, and modification targets of the encoded enzyme, consistent with their various roles in different growth niches and under varied stress conditions. The discovery of mobile colistin resistance genes, which represent lipid A-modifying pet genes that are encoded on mobile elements and associated with resistance to the last-resort antibiotic colistin, has led to substantial interest in PETs and pEtN-modified LPS over the last decade. Here, we will review the current knowledge of the functional diversity of pEtN-based LPS modifications, including possible roles in niche-specific fitness advantages and resistance to host-produced antimicrobial peptides, and discuss how the genetic and structural diversities of PETs may impact their function. An improved understanding of the PET group will further enhance our comprehension of the stress response and virulence of Gram-negative bacteria and help contextualize host-pathogen interactions.

摘要脂多糖(LPS)是革兰氏阴性细菌外膜的一个组成部分,在维持膜完整性、应激反应和毒力方面发挥着重要的结构和功能作用。LPS 由膜锚定脂质 A 基团、糖基核心区和由重复寡糖单位形成的 O 抗原组成。3-Deoxy-D-manno-octulosonic acid-lipid A(Kdo2-lipid A)是细菌生存所需的最小 LPS 成分。虽然 LPS 修饰并非必不可少,但它们在应激反应和宿主-病原体相互作用中发挥着多方面的作用。革兰氏阴性细菌编码几种不同的 LPS 修饰磷乙醇胺转移酶(PET),可将磷乙醇胺(pEtN)添加到脂质 A 或 LPS 的核心区域。这些 PET 基因的基因组位置、调控机制和编码酶的修饰靶标各不相同,这与它们在不同生长环境和不同压力条件下的不同作用是一致的。移动可乐菌素抗性基因是在移动元件上编码的脂质 A 修饰 pet 基因,与对最后一种抗生素可乐菌素的抗性有关,该基因的发现在过去十年中引起了人们对 PET 和 pEtN 修饰 LPS 的极大兴趣。在这里,我们将回顾目前关于基于 pEtN 的 LPS 修饰功能多样性的知识,包括在特定生态位的适应优势和对宿主产生的抗菌肽的抗性方面可能发挥的作用,并讨论 PET 的遗传和结构多样性可能如何影响其功能。加深对 PET 组的了解将进一步提高我们对革兰氏阴性细菌的应激反应和毒力的理解,并有助于了解宿主与病原体之间相互作用的背景。
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引用次数: 0
From soil to clinic: current advances in understanding Coccidioides and coccidioidomycosis. 从土壤到临床:了解球孢子菌和球孢子菌病的最新进展。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-10-04 DOI: 10.1128/mmbr.00161-23
Katrina M Jackson, Marcus de Melo Teixeira, Bridget M Barker

SUMMARYCoccidioides immitis and Coccidioides posadasii are fungal pathogens that cause systemic mycoses and are prevalent in arid regions in the Americas. While C. immitis mainly occurs in California and Washington, C. posadasii is widely distributed across North and South America. Both species induce coccidioidomycosis (San Joaquin Valley fever or, more commonly, Valley fever), with reported cases surging in the United States, notably in California and Arizona. Moreover, cases in Argentina, Brazil, and Mexico are on the rise. Climate change and environmental alterations conducive to Coccidioides spp. proliferation have been recently explored. Diagnostic challenges contribute to delayed treatment initiation, compounded by limited therapeutic options. Although antifungal drugs are often effective treatments, some patients do not respond to current therapies, underscoring the urgent need for a vaccine, particularly for vulnerable populations over 60 years old relocating to endemic areas. Despite recent progress, gaps persist in the understanding of Coccidioides ecology, host immune responses, and vaccine development. This review synthesizes recent research advancements in Coccidioides ecology, genomics, and immune responses, emphasizing ongoing efforts to develop a human vaccine.

摘要:水霉球孢子菌(Coccidioides immitis)和柱孢球孢子菌(Coccidioides posadasii)是引起系统性真菌病的真菌病原体,在美洲干旱地区十分普遍。C. immitis 主要分布在加利福尼亚州和华盛顿州,而 C. posadasii 则广泛分布在北美洲和南美洲。这两种球孢子菌都会诱发球孢子菌病(圣华金谷热或更常见的谷热),在美国,特别是加利福尼亚州和亚利桑那州报告的病例激增。此外,阿根廷、巴西和墨西哥的病例也在增加。气候变化和环境变化有利于球孢子虫属的扩散,最近对此进行了探讨。诊断方面的挑战导致治疗启动延迟,而有限的治疗方案又使情况更加复杂。虽然抗真菌药物通常是有效的治疗方法,但有些患者对目前的疗法没有反应,这突出表明迫切需要疫苗,特别是针对迁往流行地区的 60 岁以上易感人群。尽管最近取得了进展,但人们对球孢子菌生态学、宿主免疫反应和疫苗开发的认识仍存在差距。这篇综述综述了球孢子菌生态学、基因组学和免疫反应方面的最新研究进展,并强调了正在进行的人类疫苗开发工作。
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引用次数: 0
The biology and pathogenicity of Clostridium perfringens type F: a common human enteropathogen with a new(ish) name. F 型产气荚膜梭菌的生物学特性和致病性:一种具有新名称的常见人类肠道病原体。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-09-26 Epub Date: 2024-06-12 DOI: 10.1128/mmbr.00140-23
Archana Shrestha, Iman Mehdizadeh Gohari, Jihong Li, Mauricio Navarro, Francisco A Uzal, Bruce A McClane

SUMMARYIn the 2018-revised Clostridium perfringens typing classification system, isolates carrying the enterotoxin (cpe) and alpha toxin genes but no other typing toxin genes are now designated as type F. Type F isolates cause food poisoning and nonfoodborne human gastrointestinal (GI) diseases, which most commonly involve type F isolates carrying, respectivefooly, a chromosomal or plasmid-borne cpe gene. Compared to spores of other C. perfringens isolates, spores of type F chromosomal cpe isolates often exhibit greater resistance to food environment stresses, likely facilitating their survival in improperly prepared or stored foods. Multiple factors contribute to this spore resistance phenotype, including the production of a variant small acid-soluble protein-4. The pathogenicity of type F isolates involves sporulation-dependent C. perfringens enterotoxin (CPE) production. C. perfringens sporulation is initiated by orphan histidine kinases and sporulation-associated sigma factors that drive cpe transcription. CPE-induced cytotoxicity starts when CPE binds to claudin receptors to form a small complex (which also includes nonreceptor claudins). Approximately six small complexes oligomerize on the host cell plasma membrane surface to form a prepore. CPE molecules in that prepore apparently extend β-hairpin loops to form a β-barrel pore, allowing a Ca2+ influx that activates calpain. With low-dose CPE treatment, caspase-3-dependent apoptosis develops, while high-CPE dose treatment induces necroptosis. Those effects cause histologic damage along with fluid and electrolyte losses from the colon and small intestine. Sialidases likely contribute to type F disease by enhancing CPE action and, for NanI-producing nonfoodborne human GI disease isolates, increasing intestinal growth and colonization.

摘要在2018年修订的产气荚膜梭菌分型分类系统中,携带肠毒素(cpe)和α毒素基因但不携带其他分型毒素基因的分离物现在被指定为F型。F型分离物会引起食物中毒和非食物传播的人类胃肠道(GI)疾病,这些疾病最常涉及携带染色体或质粒携带的cpe基因的F型分离物。与其他产气荚膜杆菌分离物的孢子相比,F 型染色体 cpe 分离物的孢子通常对食品环境压力表现出更强的抵抗力,这很可能有利于它们在准备或储存不当的食品中存活。造成这种孢子抗性表型的因素有多种,包括产生一种变异的小型酸溶性蛋白-4。F 型分离物的致病性涉及依赖孢子的 C. perfringens 肠毒素(CPE)的产生。C.perfringens孢子化是由组氨酸孤儿激酶和孢子化相关的 sigma 因子启动的,这些因子驱动 cpe 转录。当 CPE 与claudin 受体结合形成一个小复合物(其中还包括非受体claudins)时,CPE 诱导的细胞毒性就开始了。大约六个小复合物在宿主细胞质膜表面寡聚,形成一个预孔。预孔中的 CPE 分子显然延伸了 β 发夹环,形成一个 β 桶状孔,允许 Ca2+ 流入,从而激活钙蛋白酶。低剂量 CPE 处理会导致依赖于 caspase-3 的细胞凋亡,而高剂量 CPE 处理则会诱导坏死。这些效应会造成组织学损伤,并导致结肠和小肠的液体和电解质流失。硅烷基糖酶可能会增强 CPE 的作用,并对产生 NanI 的非食源性人类消化道疾病分离物而言,增加肠道生长和定植,从而导致 F 型疾病。
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引用次数: 0
Molecular determinants of cross-species transmission in emerging viral infections. 新发病毒感染中跨物种传播的分子决定因素。
IF 8 1区 生物学 Q1 MICROBIOLOGY Pub Date : 2024-09-26 Epub Date: 2024-06-24 DOI: 10.1128/mmbr.00001-23
Arthur Wickenhagen, Sarah van Tol, Vincent Munster

SUMMARYSeveral examples of high-impact cross-species transmission of newly emerging or re-emerging bat-borne viruses, such as Sudan virus, Nipah virus, and severe acute respiratory syndrome coronavirus 2, have occurred in the past decades. Recent advancements in next-generation sequencing have strengthened ongoing efforts to catalog the global virome, in particular from the multitude of different bat species. However, functional characterization of these novel viruses and virus sequences is typically limited with regard to assessment of their cross-species potential. Our understanding of the intricate interplay between virus and host underlying successful cross-species transmission has focused on the basic mechanisms of entry and replication, as well as the importance of host innate immune responses. In this review, we discuss the various roles of the respective molecular mechanisms underlying cross-species transmission using different recent bat-borne viruses as examples. To delineate the crucial cellular and molecular steps underlying cross-species transmission, we propose a framework of overall characterization to improve our capacity to characterize viruses as benign, of interest, or of concern.

摘要在过去几十年中,发生了几起新出现或再次出现的蝙蝠传播病毒(如苏丹病毒、尼帕病毒和严重急性呼吸系统综合征冠状病毒 2)跨物种传播的重大事件。下一代测序技术的最新进展加强了对全球病毒组的编目工作,特别是对来自多种不同蝙蝠物种的病毒组的编目工作。然而,这些新型病毒和病毒序列的功能特征描述通常仅限于对其跨物种潜力的评估。我们对成功跨物种传播所依赖的病毒与宿主之间错综复杂的相互作用的理解主要集中在病毒进入和复制的基本机制以及宿主先天免疫反应的重要性上。在这篇综述中,我们将以近期不同的蝙蝠传播病毒为例,讨论跨物种传播背后各自分子机制的各种作用。为了描述跨物种传播的关键细胞和分子步骤,我们提出了一个整体特征描述框架,以提高我们将病毒描述为良性、相关或令人担忧的病毒的能力。
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引用次数: 0
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