IONIZING RADIATION AND CYTOKINES: THE ROLE IN THE PATHOGENESIS OF PLASMA CELL MYELOMA (LITERATURE REVIEW).

Problemy radiatsiinoi medytsyny ta radiobiolohii Pub Date : 2022-12-01 DOI:10.33145/2304-8336-2022-27-120-130
T F Liubarets
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Abstract

The review presents literature data on the role of ionizing radiation as a negative environmental factor in the occurrence of plasma cell myeloma (PCM). The data of studies of various categories of irradiated persons regarding the incidence of PCM, in particular employees of nuclear enterprises and victims of the accident at the Chornobyl Nuclear Power Plant accident, are given. The effect of cytokines (interleukin-6 and interleukin-10) on PCM substrate cells was analyzed, including under conditions of combined action of IR and cytostatic agents in vitro.

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电离辐射与细胞因子:在浆细胞骨髓瘤发病机制中的作用(文献综述)。
本文综述了电离辐射作为负环境因素在浆细胞骨髓瘤(PCM)发生中的作用的文献资料。本文给出了对各类受辐射人员，特别是核企业雇员和切尔诺贝利核电站事故受害者，关于PCM发病率的研究数据。分析细胞因子(白细胞介素-6和白细胞介素-10)对PCM底物细胞的影响，包括在体外IR和细胞抑制剂联合作用的条件下。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Problemy radiatsiinoi medytsyny ta radiobiolohii
Problemy radiatsiinoi medytsyny ta radiobiolohii Medicine-Radiology, Nuclear Medicine and Imaging
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