‘Nico’—A lone voyager in Strange Seas

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Human Psychopharmacology: Clinical and Experimental Pub Date : 2022-12-08 DOI:10.1002/hup.2859
David S. Baldwin
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Staff in a fourth hospital admitted her and ultimately diagnosed a cerebral haemorrhage, but could not insert a needle into her tired old veins: though she was undergoing methadone replacement therapy, she had previously been addicted to heroin for over 15 years.</p><p>Christa was more commonly known as ‘Nico’, and had been a model, actress, singer-songwriter and musician. She sang on four tracks of <i>The Velvet Underground and Nico (1967)</i>—including ‘Femme Fatale’ and ‘All Tomorrow's Parties'—with an austere, unornamented, deep contralto voice. Subsequent solo albums pushed against musical and emotional boundaries; and are considered unlistenable by some, ground-breaking by others. <i>The Marble Index</i> (1968),1 with its sorrowful plainsong, bleak swirling harmonium, and distorted viola gradually became regarded as an avant-garde classic. Nico associated with a <i>Who's Who</i> of male rock stars of the 1960/70s. Men were captivated by her beauty but threatened by her often scornful disdain: with notable exceptions, most treated her carelessly. In subsequent decades, she was no longer denigrated as a mere Muse or Mannequin, but instead valued as an exceptional though troubled musical visionary. But opiate addiction eroded her output remorselessly, and she spent most of her final years at the margins of the New Wave music scene, living precariously in Prestwich and Salford.</p><p>The relevance of the decline of ‘Nico’ to the concerns of psychopharmacologists and psychiatrists might seem somewhat tenuous: that is, before considering her experience of childhood trauma in wartime Germany, the recurring toll of abusive intimate relationships, and stigmatised attitudes towards drug addiction. The military call-up of her father contributed to her temporary placement in the largest orphanage in Europe, which was run according to mixed arch-Catholic and Nazi ideology. Her father subsequently died from war injuries before Christa could see him again. As a teenager she had to provide evidence at a court-martial, after being raped by a soldier of the post-war American occupying forces. As ‘Nico’, she was manipulated by a succession of men who exploited her allure, belittled her intelligence, and demeaned her artistry.</p><p>Nico showed the persistent detachment of recurrently traumatised individuals long before her preoccupying persistent concern about securing the next ‘fix’. As a single woman with only passing lovers and few possessions, and living in borrowed rooms, she was considered unsuitable to raise her son (Jennifer Otter Bickerdike, <span>2021</span>). No saint, she could both utter and act upon inexcusably virulent racist observations. The corrosive ravages of heroin dependence caused others to comment pejoratively on her appearance and behaviour, but indifferent ‘friends’ did not consider her to be either ill or in need of treatment. A recent biography is tellingly titled <i>You Are Beautiful and You Are Alone</i> (Jennifer Otter Bickerdike, <span>2021</span>).</p><p>When reading the description of her final day it is easy to be dismayed by the disparaging attitudes and neglectful behaviour of clinical staff, and to think ‘surely, that could not happen here’. But we know about this historic maltreatment of Christa only because the patient was ‘Nico’: we cannot know how many unfamiliar others at that time were treated similarly, in Ibiza or elsewhere. Is it naive to believe that currently opiate dependent patients in the United Kingdom would have a much better experience of medical and nursing care, should they present to emergency services with clinical features suggestive of severe medical illness?</p><p>Another question needs answering. Why is it that there have been so few substantial advances in developing enhanced approaches to the pharmacological treatment of patients with opiate dependence over the last 35 years? Since 1965, the mainstay of pharmacological treatment has been opioid substitution therapy using methadone or buprenorphine (Herlinger &amp; Lingford-Hughes, <span>2021</span>). Responding to the current ‘opioid crisis’ within the United States, its National Institute on Drug Abuse highlighted a range of potential mechanisms and novel targets for innovative approaches to opiate dependence; including the evaluation of orexin receptor antagonists, GABA-B agonists, muscarinic M5 antagonists, dopamine D3 receptor partial agonists, and cannabinoid CB1 receptor antagonists (Rasmussen et al., <span>2019</span>). 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Abstract

Christa Päffgen died in a corridor waiting for a hospital bed during the evening of July 18, 1988. She was 49 years old. Contemporaneous accounts state that she had cycled away from home in searing midday heat for distant downtown Ibiza hoping to buy hashish. She was found by strangers at a roadside that afternoon, unable to talk. A first hospital turned Christa away as a ‘vagrant junkie’; a second declined assessment because she had no health insurance; a third refused admission as she was an ‘old hippie’. Staff in a fourth hospital admitted her and ultimately diagnosed a cerebral haemorrhage, but could not insert a needle into her tired old veins: though she was undergoing methadone replacement therapy, she had previously been addicted to heroin for over 15 years.

Christa was more commonly known as ‘Nico’, and had been a model, actress, singer-songwriter and musician. She sang on four tracks of The Velvet Underground and Nico (1967)—including ‘Femme Fatale’ and ‘All Tomorrow's Parties'—with an austere, unornamented, deep contralto voice. Subsequent solo albums pushed against musical and emotional boundaries; and are considered unlistenable by some, ground-breaking by others. The Marble Index (1968),1 with its sorrowful plainsong, bleak swirling harmonium, and distorted viola gradually became regarded as an avant-garde classic. Nico associated with a Who's Who of male rock stars of the 1960/70s. Men were captivated by her beauty but threatened by her often scornful disdain: with notable exceptions, most treated her carelessly. In subsequent decades, she was no longer denigrated as a mere Muse or Mannequin, but instead valued as an exceptional though troubled musical visionary. But opiate addiction eroded her output remorselessly, and she spent most of her final years at the margins of the New Wave music scene, living precariously in Prestwich and Salford.

The relevance of the decline of ‘Nico’ to the concerns of psychopharmacologists and psychiatrists might seem somewhat tenuous: that is, before considering her experience of childhood trauma in wartime Germany, the recurring toll of abusive intimate relationships, and stigmatised attitudes towards drug addiction. The military call-up of her father contributed to her temporary placement in the largest orphanage in Europe, which was run according to mixed arch-Catholic and Nazi ideology. Her father subsequently died from war injuries before Christa could see him again. As a teenager she had to provide evidence at a court-martial, after being raped by a soldier of the post-war American occupying forces. As ‘Nico’, she was manipulated by a succession of men who exploited her allure, belittled her intelligence, and demeaned her artistry.

Nico showed the persistent detachment of recurrently traumatised individuals long before her preoccupying persistent concern about securing the next ‘fix’. As a single woman with only passing lovers and few possessions, and living in borrowed rooms, she was considered unsuitable to raise her son (Jennifer Otter Bickerdike, 2021). No saint, she could both utter and act upon inexcusably virulent racist observations. The corrosive ravages of heroin dependence caused others to comment pejoratively on her appearance and behaviour, but indifferent ‘friends’ did not consider her to be either ill or in need of treatment. A recent biography is tellingly titled You Are Beautiful and You Are Alone (Jennifer Otter Bickerdike, 2021).

When reading the description of her final day it is easy to be dismayed by the disparaging attitudes and neglectful behaviour of clinical staff, and to think ‘surely, that could not happen here’. But we know about this historic maltreatment of Christa only because the patient was ‘Nico’: we cannot know how many unfamiliar others at that time were treated similarly, in Ibiza or elsewhere. Is it naive to believe that currently opiate dependent patients in the United Kingdom would have a much better experience of medical and nursing care, should they present to emergency services with clinical features suggestive of severe medical illness?

Another question needs answering. Why is it that there have been so few substantial advances in developing enhanced approaches to the pharmacological treatment of patients with opiate dependence over the last 35 years? Since 1965, the mainstay of pharmacological treatment has been opioid substitution therapy using methadone or buprenorphine (Herlinger & Lingford-Hughes, 2021). Responding to the current ‘opioid crisis’ within the United States, its National Institute on Drug Abuse highlighted a range of potential mechanisms and novel targets for innovative approaches to opiate dependence; including the evaluation of orexin receptor antagonists, GABA-B agonists, muscarinic M5 antagonists, dopamine D3 receptor partial agonists, and cannabinoid CB1 receptor antagonists (Rasmussen et al., 2019). We must hope that these and other approaches together lead to the swift entry of improved medicines into clinical practice: so reducing the tragic plight of those voyaging alone on turbulent waters.

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“尼科”——《陌生海洋》里的一个孤独的航海家
1988年7月18日晚,Christa Päffgen在等待医院床位的走廊上去世。她享年49岁。当时的报道称,她冒着正午的酷热,骑车离开家,前往遥远的伊比沙岛市中心,希望能买到大麻。那天下午,陌生人在路边发现了她,她已经不会说话了。第一家医院以“流浪瘾君子”为由拒绝了克丽斯塔;第二次拒绝评估,因为她没有医疗保险;第三个人拒绝入学,因为她是一个“老嬉皮士”。第四家医院的工作人员接收了她,并最终诊断为脑溢血,但无法将针头插入她疲惫的老静脉:尽管她正在接受美沙酮替代疗法,但她此前已经吸食海洛因超过15年。克里斯塔更广为人知的名字是“尼科”,她曾是模特、演员、创作歌手和音乐家。她在《地下丝绒》和《尼科》(1967)的四首曲目中演唱,包括《蛇形美人》和《明日派对》,她的女低音质朴、朴实、低沉。随后的个人专辑打破了音乐和情感的界限;有些人认为这是不可听的,而另一些人则认为这是突破性的。《大理石指数》(Marble Index, 1968)以悲伤的平淡歌曲、凄凉的旋转和声和扭曲的中提琴逐渐成为先锋经典。Nico与20世纪60年代至70年代的男性摇滚明星名人录有关。男人们被她的美貌迷住了,但又被她经常轻蔑的蔑视所威胁:除了明显的例外,大多数人都对她漫不经心。在随后的几十年里,她不再被诋毁为仅仅是缪斯女神或人体模特,而是被视为一位杰出的、尽管陷入困境的音乐梦想家。但鸦片成瘾无情地侵蚀了她的作品,她在最后几年的大部分时间里都处于新浪潮音乐场景的边缘,在普雷斯特维奇和索尔福德过着不稳定的生活。“Nico”的衰落与精神药理学家和精神病学家的担忧之间的相关性似乎有些脆弱:也就是说,在考虑到她在战时德国的童年创伤经历,虐待亲密关系的反复出现的代价,以及对吸毒成瘾的污名化态度之前。她父亲的军事征召使她暂时被安置在欧洲最大的孤儿院,这是根据天主教和纳粹的混合意识形态经营的。她的父亲后来死于战争创伤,克丽斯塔还没来得及见到他。十几岁的时候,她被战后美国占领军的一名士兵强奸,不得不在军事法庭上提供证据。作为“尼科”,她被一连串的男人所操纵,他们利用她的魅力,贬低她的智慧,贬低她的艺术。早在她全神贯注地持续关注下一个“修复”之前,尼科就表现出了对经常性创伤个体的持续超然。作为一个单身女人,只有路过的情人和很少的财产,住在借来的房间里,她被认为不适合抚养她的儿子(Jennifer Otter Bickerdike, 2021)。她不是圣人,她既能说出不可原谅的恶毒的种族主义言论,又能按照这些言论行事。海洛因依赖的破坏性破坏导致其他人对她的外表和行为进行轻蔑的评论,但冷漠的“朋友”并不认为她有病或需要治疗。最近的一本传记《你是美丽的,你是孤独的》(Jennifer Otter Bickerdike, 2021年出版)。当读到她最后一天的描述时,很容易对临床工作人员的轻蔑态度和忽视行为感到沮丧,并认为“当然,这种情况不可能发生在这里”。但我们知道克里斯塔遭受的这种历史性虐待,只是因为这个病人叫“尼科”:我们不知道当时在伊比沙岛或其他地方,有多少不熟悉的人受到了类似的对待。如果英国目前的阿片类药物依赖患者出现严重疾病的临床特征,认为他们会有更好的医疗和护理体验,这是否天真?另一个问题需要回答。为什么在过去的35年里,在开发增强阿片类药物依赖患者的药物治疗方法方面几乎没有实质性的进展?自1965年以来,主要的药物治疗是使用美沙酮或丁丙诺啡的阿片类药物替代疗法(Herlinger &Lingford-Hughes, 2021)。针对美国国内目前的“阿片类药物危机”,其国家药物滥用研究所强调了解决阿片类药物依赖的创新方法的一系列潜在机制和新目标;包括食欲素受体拮抗剂、GABA-B激动剂、毒蕈碱M5拮抗剂、多巴胺D3受体部分激动剂和大麻素CB1受体拮抗剂的评估(Rasmussen等人,2019)。 我们必须希望,这些方法和其他方法结合起来,能使改进后的药物迅速进入临床实践,从而减少那些独自在湍流中航行的人的悲惨困境。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
34
审稿时长
6-12 weeks
期刊介绍: Human Psychopharmacology: Clinical and Experimental provides a forum for the evaluation of clinical and experimental research on both new and established psychotropic medicines. Experimental studies of other centrally active drugs, including herbal products, in clinical, social and psychological contexts, as well as clinical/scientific papers on drugs of abuse and drug dependency will also be considered. While the primary purpose of the Journal is to publish the results of clinical research, the results of animal studies relevant to human psychopharmacology are welcome. The following topics are of special interest to the editors and readers of the Journal: -All aspects of clinical psychopharmacology- Efficacy and safety studies of novel and standard psychotropic drugs- Studies of the adverse effects of psychotropic drugs- Effects of psychotropic drugs on normal physiological processes- Geriatric and paediatric psychopharmacology- Ethical and psychosocial aspects of drug use and misuse- Psychopharmacological aspects of sleep and chronobiology- Neuroimaging and psychoactive drugs- Phytopharmacology and psychoactive substances- Drug treatment of neurological disorders- Mechanisms of action of psychotropic drugs- Ethnopsychopharmacology- Pharmacogenetic aspects of mental illness and drug response- Psychometrics: psychopharmacological methods and experimental design
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