Optimization of exercise preconditioning duration in protecting from exhausted exercise-induced cardiac injury in rats.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-11-01 DOI:10.4103/0304-4920.365457

Zheng Ping, Jinyu Li, Yawei Sun, Xiaoli Zhang, Ziwen Wang, Xuebin Cao

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Abstract

The effect of different duration of exercise preconditioning (EP) on protecting from exhaustive exercise-induced cardiac injury (EECI) has been optimized in rats. Male Sprague-Dawley rats were divided into six groups: the control group, exhaustive exercise (EE) group, EP 20-min + EE group, EP 40-min + EE group, EP 60-min + EE group and EP 80-min + EE group. The EP groups were subjected to treadmill running at the intensity of 74.0% V̇O_{2 max}. Changes of exercise capacity, cardiac pathology, myocardial enzymology, electrocardiogram (ECG), cardiac function, and mitochondrial respiratory function were compared. Compared to the C group, the EE group has shown significant decrease of exercise capacity, elevation of serum N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin-I (cTn-I) levels, cardiac morphology change, ECG disturbance, cardiac dysfunction and reduction of myocardial mitochondrial respiration function. Compared to the EE group, the EP groups have shown significant elevation of exercise capacity, decrease of serum NT-proBNP and cTn-I, improvement of cardiac function and myocardial mitochondrial electron transfer pathway complex I, II and IV activity. The correlation analyses showed protection of EP was proportional to EP duration from 20-min to 60-min. EE caused cardiac injury. EP could protect from EECI by alleviating myocardial damage, improving cardiac function and mitochondrial ETP complex I, II and IV activity. EP protection was positively correlated to EP duration from 20-min to 60-min with EP intensity fixed at 74.0% V̇O_{2 max}.

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优化运动预处理时间对大鼠运动性心力损伤的保护作用。

研究了不同时间运动预处理(EP)对大鼠运动性心力损伤的保护作用。雄性Sprague-Dawley大鼠分为6组:对照组、力竭运动组、EP 20 min + EE组、EP 40 min + EE组、EP 60 min + EE组和EP 80 min + EE组。EP组以74.0%的最大V (O2)强度进行跑步。比较运动能力、心脏病理、心肌酶学、心电图、心功能和线粒体呼吸功能的变化。与C组相比，EE组运动能力明显下降，血清n端前b型利钠肽(NT-proBNP)和心肌肌钙蛋白- i (cTn-I)水平升高，心脏形态改变，心电图紊乱，心功能障碍，心肌线粒体呼吸功能降低。与EE组相比，EP组运动能力明显提高，血清NT-proBNP和cTn-I水平明显降低，心功能和心肌线粒体电子传递通路复合物I、II和IV活性明显改善。相关分析显示，EP的保护作用与EP持续时间(20 ~ 60 min)成正比。EE引起心脏损伤。EP可通过减轻心肌损伤、改善心功能和线粒体ETP复合体I、II和IV活性来保护EECI。EP保护作用与EP持续时间(20 ~ 60 min)呈正相关，EP强度固定在74.0% V / O2 max。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.