A potential role of hippocampus on impulsivity and alcohol consumption through CB1R

IF 3.3 3区心理学 Q1 BEHAVIORAL SCIENCES Pharmacology Biochemistry and Behavior Pub Date : 2023-04-01 DOI:10.1016/j.pbb.2023.173558

B.M. Romero-Torres , Y.A. Alvarado-Ramírez , S.R. Duran-Alonzo , A.E. Ruiz-Contreras , A. Herrera-Solis , O. Amancio-Belmont , O.E. Prospéro-García , M. Méndez-Díaz

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引用次数: 2

Abstract

There are a few studies suggesting that the hippocampus is involved in the regulation of impulsivity, and which attempt to explain drug seeking behavior in addiction. In addition, cannabinoid receptor 1 (CB1R) is highly expressed in the hippocampus (HPP). To further understand the potential role of the hippocampal CB1R in impulsive and drug seeking behaviors, we characterized impulsivity in adolescent and adult male rats, by means of a delay discounting task (DDT) by evaluating preference and seeking motivation for alcohol (10 % v/v) consumption, and analyzing CB1R expression in CA1, CA3 and the dentate gyrus (DG) of the HPP as well as in the medial prefrontal cortex (mPFC). Our results show that adolescent rats display more impulsive choices than adult rats in the DDT. The k value is statistically higher in adolescents, further supporting that they are more impulsive. Besides, adolescent rats have higher forced and voluntary alcohol consumption and display a higher alcohol conditioned place preference (CPP) vs. adult rats. In addition, CB1R expression in CA3 and the DG is higher in adolescent vs. adult rats. Our data further support the role of the hippocampus in impulsivity with the potential involvement of the endocannabinoid system, considering that CB1R in CA3 and DG is higher in adolescents, who display impulsivity and alcohol seeking and consumption.

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海马体通过CB1R对冲动性和酒精消耗的潜在作用

有一些研究表明，海马体参与了冲动性的调节，并试图解释成瘾中的药物寻求行为。此外，大麻素受体1（CB1R）在海马体（HPP）中高度表达。为了进一步了解海马CB1R在冲动和药物寻求行为中的潜在作用，我们通过延迟折扣任务（DDT）对青少年和成年雄性大鼠的冲动性进行了表征，通过评估饮酒（10%v/v）的偏好和寻求动机，并分析了CA1中CB1R的表达，CA3和HPP的齿状回（DG）以及内侧前额叶皮层（mPFC）。我们的研究结果表明，在滴滴涕中，青春期大鼠比成年大鼠表现出更多的冲动选择。从统计数据来看，青少年的k值更高，这进一步证明他们更容易冲动。此外，与成年大鼠相比，青春期大鼠具有更高的强迫和自愿饮酒量，并表现出更高的酒精条件场所偏好（CPP）。此外，青少年大鼠CA3和DG中CB1R的表达高于成年大鼠。我们的数据进一步支持了海马体在冲动中的作用，并可能涉及内源性大麻素系统，考虑到CA3和DG中的CB1R在青少年中更高，他们表现出冲动和酗酒和消费。

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来源期刊

Pharmacology Biochemistry and Behavior 医学-行为科学

CiteScore

6.40

自引率

2.80%

发文量

122

审稿时长

38 days

期刊介绍： Pharmacology Biochemistry & Behavior publishes original reports in the areas of pharmacology and biochemistry in which the primary emphasis and theoretical context are behavioral. Contributions may involve clinical, preclinical, or basic research. Purely biochemical or toxicology studies will not be published. Papers describing the behavioral effects of novel drugs in models of psychiatric, neurological and cognitive disorders, and central pain must include a positive control unless the paper is on a disease where such a drug is not available yet. Papers focusing on physiological processes (e.g., peripheral pain mechanisms, body temperature regulation, seizure activity) are not accepted as we would like to retain the focus of Pharmacology Biochemistry & Behavior on behavior and its interaction with the biochemistry and neurochemistry of the central nervous system. Papers describing the effects of plant materials are generally not considered, unless the active ingredients are studied, the extraction method is well described, the doses tested are known, and clear and definite experimental evidence on the mechanism of action of the active ingredients is provided.