An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Biosafety and Health Pub Date : 2022-12-01 DOI:10.1016/j.bsheal.2022.10.003

Meiling Zhang , Zhixiao Chen , Jienan Zhou , Xiaonan Zhao , Yaoyao Chen , Yanhong Sun , Zhaosheng Liu , Wenpeng Gu , Chunrui Luo , Xiaoqing Fu , Xiang Zhao

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引用次数: 3

Abstract

The Omicron variants spread rapidly worldwide after being initially detected in South Africa in November 2021. It showed increased transmissibility and immune evasion with far more amino acid mutations in the spike (S) protein than the previously circulating variants of concern (VOCs). Notably, on 15 July 2022, we monitored the first VOC / Omicron subvariant BA.2.75 in China from an imported case. Moreover, nowadays, this subvariant still is predominant in India. It has nine additional mutations in the S protein compared to BA.2, three of which (W152R, G446S, and R493Q reversion) might contribute to higher transmissibility and immune escape. This subvariant could cause wider spread and pose a threat to the global situation. Our timely reporting and continuous genomic analysis are essential to fully elucidate the characteristics of the subvariant BA.2.75 in the future.

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云南省输入性人感染SARS-CoV-2基因组亚变体BA.2.75病例

欧米克隆变异自2021年11月在南非首次发现后，迅速在全球传播。它显示出增加的传播性和免疫逃避，在刺突(S)蛋白中有更多的氨基酸突变，而不是以前循环的关注变体(VOCs)。值得注意的是，在2022年7月15日，我们从一个输入病例中监测到了中国第一个VOC /欧米克隆亚变体BA.2.75。而且，现在这种亚变种在印度仍然占主导地位。与BA.2相比，它在S蛋白上有9个额外的突变，其中3个(W152R、G446S和R493Q逆转)可能有助于更高的传播率和免疫逃逸。这一亚型可能导致更广泛的传播，并对全球局势构成威胁。我们的及时报道和持续的基因组分析对于未来充分阐明BA.2.75亚变体的特征至关重要。

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