Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis.

IF 2.9 3区 医学 Q2 RESPIRATORY SYSTEM Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-06-26 DOI:10.1080/17476348.2023.2228194
Alexander Yule, Darren Sills, Sherie Smith, Robin Spiller, Alan R Smyth
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Abstract

Introduction: Gastrointestinal (GI)-related symptoms, complications, and comorbidities in cystic fibrosis (CF) are common and research to reduce their burden is a priority for the CF community. To enable future research, this review aimed to summarize the range of GI symptoms, complications and comorbidities seen in CF, the underlying pathophysiology, and treatments.

Areas covered: This was a rapid systematic review undertaken using the recommendations from the Cochrane Rapid Reviews Methods Group. We searched databases including PubMed, Embase, Medline and the Cochrane database and identified those studies reporting GI-related symptoms, complications, or comorbidities in CF or their treatment. Our searches identified 2,930 studies and a total 119 studies met our inclusion criteria. Where a prevalence could be determined, GI symptoms were reported in 33.7% of study participants. The range of symptoms reported was broad and the highest median prevalence included flatulence (43.5%), bloating and abdominal distension (36%), and fatty stool (36%). Meconium ileus was reported in 12% and distal intestinal obstruction syndrome in 8.5.

Expert opinion: GI-related symptoms, complications, and comorbidities in CF are common. More consistent characterization and recording of these symptoms in clinical studies may help achieve the priority of reducing the burden of GI disease in CF.

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跳出框框思考:囊性纤维化胃肠道症状和并发症综述。
引言:囊性纤维化(CF)的胃肠道(GI)相关症状、并发症和合并症很常见,减少其负担的研究是CF社区的优先事项。为了便于未来的研究,这篇综述旨在总结CF中出现的胃肠道症状、并发症和合并症的范围、潜在的病理生理学和治疗方法。涵盖的领域:这是一项使用Cochrane快速审查方法小组的建议进行的快速系统审查。我们搜索了包括PubMed、Embase、Medline和Cochrane数据库在内的数据库,并确定了那些报告CF或其治疗中胃肠道相关症状、并发症或合并症的研究。我们的检索确定了2930项研究,共有119项研究符合我们的纳入标准。在可以确定患病率的情况下,33.7%的研究参与者报告了胃肠道症状。报告的症状范围很广,最高的中位患病率包括胀气(43.5%)、腹胀和腹胀(36%)以及脂肪粪便(36%)。12%的患者报告了胎粪性肠梗阻,8.5.报告了远端肠梗阻综合征。专家意见:CF中常见的胃肠道相关症状、并发症和合并症。在临床研究中对这些症状进行更一致的表征和记录可能有助于优先减轻CF中胃肠道疾病的负担。
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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
90
期刊介绍: Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity
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