KCNQ Potassium Channels as Targets of Botanical Folk Medicines.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Annual review of pharmacology and toxicology Pub Date : 2022-01-06 Epub Date: 2021-09-13 DOI:10.1146/annurev-pharmtox-052120-104249
Kaitlyn E Redford, Geoffrey W Abbott
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Abstract

Since prehistory, human species have depended on plants for both food and medicine. Even in countries with ready access to modern medicines, alternative treatments are still highly regarded and commonly used. Unlike modern pharmaceuticals, many botanical medicines are in widespread use despite a lack of safety and efficacy data derived from controlled clinical trials and often unclear mechanisms of action. Contributing to this are the complex and undefined composition and likely multifactorial mechanisms of action and multiple targets of many botanical medicines. Here, we review the newfound importance of the ubiquitous KCNQ subfamily of voltage-gated potassium channels as targets for botanical medicines, including basil, capers, cilantro, lavender, fennel, chamomile, ginger, and Camellia, Sophora, and Mallotus species. We discuss the implications for the traditional use of these plants for disorders such as seizures, hypertension, and diabetes and the molecular mechanisms of plant secondary metabolite effects on KCNQ channels.

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作为民间植物药靶点的 KCNQ 钾通道
自史前时代起,人类就依赖植物作为食物和药物。即使在现代医学发达的国家,替代疗法仍然备受推崇并被广泛使用。与现代药物不同,许多植物药尽管缺乏临床对照试验得出的安全性和有效性数据,而且通常作用机制不明确,但仍被广泛使用。造成这种情况的原因是许多植物药的成分复杂且未确定,可能具有多因素作用机制和多靶点。在此,我们回顾了新发现的无处不在的电压门控钾通道 KCNQ 亚家族作为植物药靶点的重要性,这些靶点包括罗勒、辣椒、香菜、薰衣草、茴香、甘菊、生姜以及山茶、槐树和野百合等物种。我们讨论了传统上使用这些植物治疗癫痫、高血压和糖尿病等疾病的意义,以及植物次生代谢物对 KCNQ 通道影响的分子机制。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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