A Qualitative Analysis of First-Hand Accounts of Diphenhydramine Misuse Available on YouTube.

IF 2.1 4区 医学 Q2 PSYCHOLOGY, CLINICAL Journal of psychoactive drugs Pub Date : 2024-11-01 Epub Date: 2023-08-31 DOI:10.1080/02791072.2023.2251985
Haley Maria Dourron, Heith Copes, Agasthya Vedre-Kyanam, Daniel D Reyes, Maggie Gossage, Noah Wiles Sweat, Peter S Hendricks
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Abstract

Deliriants are the least studied class of hallucinogens and display noticeable subjective effects, including dysphoria, hallucinations, and substantial alterations in thought. High doses of diphenhydramine (DPH), an over-the-counter antihistamine medication, can produce deliriant effects due to secondary anticholinergic activity. We sought to characterize the subjective experiences produced by DPH misuse to better understand deliriants more broadly and the context under which DPH misuse occurs. To conduct our analysis, 32 first-hand accounts of DPH misuse publicly available in YouTube videos were analyzed using inductive thematic analysis. Video makers discussed alterations in most sensory modalities, confusion, and a tendency for strongly unpleasant experiences. Occasionally, video makers reported positive effects, although these were rare and often overshadowed by negative aspects of the experience. Video makers frequently warned against misusing DPH, and these individuals occasionally reported adverse post-acute effects. Despite the prevalence of adverse experiences, patterns of repeated misuse were sometimes discussed. Motives for misusing DPH, when mentioned, included accessibility, affordability, and legality. Overall, findings suggest DPH misuse can produce substantial psychoactive effects that are often distressing and share some phenomenological overlap with experiences produced by psychosis.

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对 YouTube 上有关滥用苯海拉明的第一手资料进行定性分析。
谵妄药是研究最少的一类致幻剂,具有明显的主观效应,包括幻觉障碍、幻觉和思维的实质性改变。大剂量苯海拉明(DPH)是一种非处方抗组胺药物,由于其继发性抗胆碱能活性,可产生谵妄效应。我们试图描述滥用苯海拉明所产生的主观体验,以便更好地了解谵妄患者以及滥用苯海拉明的背景。为了进行分析,我们使用归纳主题分析法对 YouTube 视频中公开的 32 个关于滥用 DPH 的第一手描述进行了分析。视频制作者讨论了大多数感官模式的改变、困惑以及强烈不愉快体验的倾向。偶尔,视频制作者也会报告一些积极的影响,尽管这些影响并不多见,而且往往被体验的负面影响所掩盖。视频制作者经常告诫人们不要滥用 DPH,这些人偶尔也会报告急性期后的不良反应。尽管不良经历很普遍,但有时也会讨论反复滥用的模式。当提及滥用 DPH 的动机时,其中包括可获得性、可负担性和合法性。总之,研究结果表明,DPH 的滥用会产生巨大的精神作用,这些作用往往令人痛苦,并与精神病产生的体验有一些现象上的重叠。
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来源期刊
CiteScore
5.30
自引率
7.10%
发文量
62
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