Lavender (Lavandula angustifolia) syrup as an adjunct to standard care in patients with mild to moderate COVID-19: An open-label, randomized, controlled clinical trial.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-07-01 DOI:10.22038/AJP.2022.21606
Marzieh Qaraaty, Mohsen Bahrami, Sadegh-Ali Azimi, Fataneh Hashem-Dabaghian, Safoora Saberi, Syed Mohd Abbas Zaidi, Amirhossein Sahebkar, Ayesheh Enayati
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Abstract

Objective: ongoing COVID-19 pandemic has been associated with clinical signs characterized by fever, fatigue and cough. Our study aimed to assess the efficacy of a Persian medicine formulation, lavender syrup, as an add-on to standard care in patients with mild to moderate COVID-19.

Materials and methods: In this clinical trial which was conducted in Gorgan (Iran), 84 male and female COVID-19 outpatients were randomly allocated to either lavender syrup receiving 9 ml/twice/day for 21 days with standard conventional care or control groups. The primary objectives were to assess the improvement of clinical symptoms, while the secondary objectives were treatment satisfaction and anxiety levels which were evaluated once a week for 3 weeks.

Results: Out of 84 participants, 81 were analyzed (41 in the add-on group). The comparison between groups for cough severity and anosmia showed a higher reduction in the lavender group. The effect size was 0.6 for cough relief. Other symptoms and the Hamilton total score decreased in both groups with no statistically significant differences between the groups. The lavender group showed greater patients' satisfaction score.

Conclusion: Adjunctive therapy with lavender syrup could reduce cough and improve the quality of life in patients with COVID-19 patients.

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薰衣草(Lavandula angustifolia)糖浆作为轻度至中度新冠肺炎患者标准护理的辅助药物:一项开放、随机、对照的临床试验。
目的:持续的新冠肺炎大流行与以发烧、疲劳和咳嗽为特征的临床体征有关。我们的研究旨在评估波斯药物配方薰衣草糖浆作为轻度至中度COVID-19患者标准护理的附加药物的疗效。材料和方法:在Gorgan(伊朗)进行的这项临床试验中,84名新冠肺炎男性和女性门诊患者被随机分配到标准常规护理组或对照组,接受9毫升/两次/天的薰衣草糖浆治疗21天。主要目标是评估临床症状的改善,而次要目标是治疗满意度和焦虑水平,每周评估一次,持续3周。结果:在84名参与者中,81人接受了分析(附加组41人)。两组之间咳嗽严重程度和嗅觉缺失的比较显示,薰衣草组的减少程度更高。咳嗽缓解的效果大小为0.6。其他症状和汉密尔顿总分在两组中均有所下降,两组之间无统计学显著差异。薰衣草组患者的满意度得分更高。结论:薰衣草糖浆辅助治疗可减轻新冠肺炎患者咳嗽,改善患者生活质量。
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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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