Differential fat accumulation in early adulthood according to adolescent-BMI and heavy metal exposure.

IF 3.4 3区心理学 Q1 PSYCHOLOGY, DEVELOPMENTAL New Directions for Child and Adolescent Development Pub Date : 2022-03-01 Epub Date: 2022-05-19 DOI:10.1002/cad.20463

Larissa Betanzos-Robledo, Martha M Téllez-Rojo, Hector Lamadrid-Figueroa, Ernesto Roldan-Valadez, Karen E Peterson, Erica C Jansen, Nil Basu, Alejandra Cantoral

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Abstract

Introduction: Heavy metals such as Lead (Pb) and Mercury (Hg) can affect adipose tissue mass and function. Considering the high prevalence of exposure to heavy metals and obesity in Mexico, we aim to examine if exposure to Pb and Hg in adolescence can modify how fat is accumulated in early adulthood.

Methods: This study included 100 participants from the ELEMENT cohort in Mexico. Adolescent Pb and Hg blood levels were determined at 14-16 years. Age- and sex-specific adolescent BMI Z-scores were calculated. At early adulthood (21-22 years), fat accumulation measurements were performed (abdominal, subcutaneous, visceral, hepatic, and pancreatic fat). Linear regression models with an interaction between adolescent BMI Z-score and Pb or Hg levels were run for each adulthood fat accumulation outcome with normal BMI as reference.

Results: In adolescents with obesity compared to normal BMI, as Pb exposure increased, subcutaneous (p-interaction = 0.088) and visceral (p-interaction < 0.0001) fat accumulation increases. Meanwhile, Hg was associated with subcutaneous (p-interaction = 0.027) and abdominal (p-interaction = 0.022) fat deposition among adolescents with obesity.

Conclusions: Heavy metal exposure in adolescence may alter how fat is accumulated in later periods of life.

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根据青春期体重指数和重金属接触情况，成年早期的脂肪积累存在差异。

导言：铅（Pb）和汞（Hg）等重金属会影响脂肪组织的质量和功能。考虑到墨西哥重金属暴露和肥胖症的高发率，我们旨在研究青少年时期接触铅和汞是否会改变脂肪在成年早期的积累方式：这项研究包括来自墨西哥 ELEMENT 队列的 100 名参与者。测定了 14-16 岁青少年血液中的铅和汞水平。计算了特定年龄和性别的青少年体重指数 Z 值。在成年早期（21-22 岁），进行了脂肪堆积测量（腹部脂肪、皮下脂肪、内脏脂肪、肝脏脂肪和胰腺脂肪）。以正常体重指数为参考，针对每个成年期脂肪积累结果，建立了青少年体重指数 Z 值与铅或汞水平相互作用的线性回归模型：结果：与正常体重指数相比，在肥胖青少年中，随着铅暴露量的增加，皮下（p-交互作用=0.088）和内脏（p-交互作用=0.088）的脂肪累积量也会增加：青少年时期接触重金属可能会改变以后的脂肪积累方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

New Directions for Child and Adolescent Development PSYCHOLOGY, DEVELOPMENTAL-

CiteScore

7.70

自引率

3.60%

发文量

期刊介绍： The mission of New Directions for Child and Adolescent Development is to provide scientific and scholarly presentations on cutting edge issues and concepts in the field of child and adolescent development. Each issue focuses on a specific new direction or research topic, and is peer reviewed by experts on that topic. Any topic in the domain of child and adolescent development can be the focus of an issue. Topics can include social, cognitive, educational, emotional, biological, neuroscience, health, demographic, economical, and socio-cultural issues that bear on children and youth, as well as issues in research methodology and other domains. Topics that bridge across areas are encouraged, as well as those that are international in focus or deal with under-represented groups. The readership for the journal is primarily students, researchers, scholars, and social servants from fields such as psychology, sociology, education, social work, anthropology, neuroscience, and health. We welcome scholars with diverse methodological and epistemological orientations.