Relationship of Histopathologic Parameters and Gene Expression Profiling in Malignant Melanoma

IF 8.6 1区 医学 Q1 DERMATOLOGY American Journal of Clinical Dermatology Pub Date : 2023-09-04 DOI:10.1007/s40257-023-00815-2
Alexis G. Strahan, Ivan Švagelj, Drazen Jukic
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Abstract

Background

Histopathologic characteristics (HC) are a mainstay in melanoma prognosis; gene expression profiling (GEP) has emerged as a potential additional independent value.

Objective

To elucidate HC predictive of groups obtained via GEP of malignant melanoma.

Methods

A retrospective study analyzing HC of 265 melanomas submitted for GEP over the course of 8 years. GEP was conducted as a part of regular clinicopathologic workup through Castle Biosciences Decision Dx®.

Results

Of the 265 cases, the major HC found to have an association with reported gene expression profiles were melanoma histology subtype, depth of invasion, and presence of ulcer.

Limitations

This study is limited by its cross-sectional nature. Causation and long-term related outcomes of the use of GEP versus American Joint Committee on Cancer histopathologic staging cannot be ascertained by this design.

Conclusions

An association, but no definitive prediction, exists between histopathologic categories of depth of invasion, melanoma subtype, and presence or absence of ulcer and gene expression profiles. GEP adds valuable data to the evaluation of malignant melanomas that cannot be definitively predicted by conventional models. The findings add to needed groundwork for comparison of traditional markers and molecular genotyping and begins to build a robust predictive model for better outcomes in patients with malignant melanoma.

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恶性黑色素瘤组织病理学参数与基因表达谱的关系
背景:组织病理学特征(HC)是黑色素瘤预后的主要依据;基因表达谱分析(GEP)已成为一种潜在的附加独立价值:方法:一项回顾性研究分析了恶性黑色素瘤的组织病理学特征(HC)和基因表达谱(GEP):方法:一项回顾性研究,分析 8 年间提交 GEP 的 265 例黑色素瘤的 HC。GEP是通过Castle Biosciences Decision Dx®进行的常规临床病理检查的一部分:结果:在265个病例中,发现与报告的基因表达谱相关的主要HC是黑色素瘤组织学亚型、侵袭深度和溃疡的存在:局限性:本研究因其横断面性质而受到限制。局限性:本研究因其横断面性质而受到限制,使用 GEP 与美国癌症联合委员会组织病理学分期的因果关系和长期相关结果无法通过这种设计来确定:结论:侵袭深度、黑色素瘤亚型、有无溃疡等组织病理学分类与基因表达谱之间存在关联,但没有明确的预测。GEP为评估传统模型无法明确预测的恶性黑色素瘤提供了有价值的数据。这些发现为比较传统标记物和分子基因分型奠定了基础,并开始建立一个强大的预测模型,为恶性黑色素瘤患者带来更好的治疗效果。
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来源期刊
CiteScore
15.20
自引率
2.70%
发文量
84
审稿时长
>12 weeks
期刊介绍: The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.
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