{"title":"Mitotic Antipairing of Homologous Chromosomes.","authors":"Lisa L Hua, Christian J Casas, Takashi Mikawa","doi":"10.1007/978-3-031-06573-6_6","DOIUrl":null,"url":null,"abstract":"<p><p>Chromosome organization is highly dynamic and plays an essential role during cell function. It was recently found that pairs of the homologous chromosomes are continuously separated at mitosis and display a haploid (1n) chromosome set, or \"antipairing,\" organization in human cells. Here, we provide an introduction to the current knowledge of homologous antipairing in humans and its implications in human disease.</p>","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731508/pdf/nihms-1850357.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results and Problems in Cell Differentiation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-031-06573-6_6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
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Abstract
Chromosome organization is highly dynamic and plays an essential role during cell function. It was recently found that pairs of the homologous chromosomes are continuously separated at mitosis and display a haploid (1n) chromosome set, or "antipairing," organization in human cells. Here, we provide an introduction to the current knowledge of homologous antipairing in humans and its implications in human disease.
期刊介绍：
Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.
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