Evaluating construct and criterion validity of NeuroScreen in assessing neurocognition among hospitalized Ugandan first-episode psychosis patients

IF 2.3 Q2 PSYCHIATRY Schizophrenia Research-Cognition Pub Date : 2023-06-01 DOI:10.1016/j.scog.2022.100276
Nana Asiedu , Emmanuel Kiiza Mwesiga , Dickens Akena , Corey Morrison , Joy Louise Gumikiriza-Onoria , Angel Nanteza , Juliet Nakku , Nastassja Koen , Noeline Nakasujja , Wilber Ssembajjwe , Christopher M. Ferraris , Anthony F. Santoro , Dan J. Stein , Reuben N. Robbins
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Abstract

Introduction

Neurocognitive impairment (NCI) is commonly exhibited among patients experiencing their first episode of psychosis. However, there are few resources in many low-income countries, such as Uganda, that allow for the administration of extensive neurocognitive test batteries for the detection of NCI. NeuroScreen is a brief tablet-based neurocognitive assessment battery that can be administered by all levels of healthcare staff. We examined the validity of NeuroScreen to assess neurocognition and detect NCI in first-episode psychosis (FEP) patients in Uganda.

Methods

We enrolled 112 participants FEP patients and matched controls at Butabika Mental Referral Hospital. Each participant completed NeuroScreen and a traditionally administered neurocognitive battery: the MATRIC Consensus Cognitive Battery (MCCB). We examined correlations between participant performance on NeuroScreen and the MCCB. A ROC curve determined sensitivity and specificity of NeuroScreen to detect NCI as determined by MCCB criterion.

Results

There was a large, statistically significant correlation between overall performance on NeuroScreen and the MCCB [r(112) = 0.64, p < .001]. Small to large correlations were found between tests in the MCCB and NeuroScreen batteries. The ROC curve of NeuroScreen performance to detect MCCB-defined NCI had an area under curve of 0.80 and optimal sensitivity and specificity of 83 % and 60 %, respectively.

Conclusion

There was a moderate positive correlation between overall performance on both batteries. NeuroScreen shows promise as a valid assessment battery to assess neurocognition and detect NCI in FEP patients in Uganda. Further studies of NeuroScreen in healthy individuals and in a range of mental disorders are recommended.

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评估NeuroScreen在乌干达住院首发精神病患者神经认知方面的结构和标准有效性
引言神经认知障碍(NCI)通常表现在经历第一次精神病发作的患者中。然而,在乌干达等许多低收入国家,很少有资源允许管理广泛的神经认知测试组来检测NCI。NeuroScreen是一个简短的基于平板电脑的神经认知评估组,可以由各级医护人员进行管理。我们检验了NeuroScreen在乌干达首次精神病(FEP)患者中评估神经认知和检测NCI的有效性。每个参与者都完成了NeuroScreen和一个传统管理的神经认知电池:MATRIC共识认知电池(MCCB)。我们研究了参与者在NeuroScreen上的表现和MCCB之间的相关性。ROC曲线确定了根据MCCB标准确定的NeuroScreen检测NCI的敏感性和特异性。结果NeuroScreen的整体表现与MCCB之间存在很大的统计学显著相关性[r(112)=0.64,p<;.001]。MCCB和NeuroScreen电池的测试之间存在小到大的相关性。NeuroScreen检测MCCB定义的NCI的ROC曲线下面积为0.80,最佳灵敏度和特异性分别为83%和60%。结论两种电池的整体性能之间存在中度正相关。NeuroScreen有望成为乌干达FEP患者评估神经认知和检测NCI的有效评估组。建议对健康个体和一系列精神障碍进行进一步的神经筛查研究。
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来源期刊
CiteScore
5.60
自引率
10.70%
发文量
54
审稿时长
67 days
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