Role of Vitamin D in Management of Diabetes and Unresolved Cardiovascular Diseases.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-01-01 DOI:10.2174/1573399820666230901151019

Prabhat Kumar Upadhyay, Navneet Thakur, Vishal Kumar Vishwakarma, Ritesh Kumar Srivastav, Tarique Mahmood Ansari

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Abstract

Background: Vitamin D deficiency is becoming a widely recognized global health issue. Serum values of 25-(OH) vitamin D (<20 ng/ml) are used to identify vitamin D deficiency. By prompting vascular endothelial cells to activate their nuclear receptor in cardio-myocytes, Vitamin D regulates obesity, Renin-angiotensin system (RAS), energy consumption, and pancreatic cell function. Vitamin D deficiency has been associated with diabetes, asthma, hyperlipidaemia, and pulmonary hypertension in humans.

Methods: PubMed and Google Scholar databases were utilised to search the literature on vitamin D and related diseases.

Result: It is also linked to an elevated risk of death and heart disease. On the other hand, metaanalyses of vitamin D intervention and trials have found no substantial changes in insulin sensitivity, lipid markers, or blood pressure, which result in the association between deficiency of vitamin D and cardiovascular disease.

Conclusion: In this review, we present the most recent research on the effects of Vitamin D therapy on various cardiovascular diseases and diabetes, and explain the underlying mechanisms.

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维生素 D 在治疗糖尿病和未治愈的心血管疾病中的作用。

背景：维生素 D 缺乏症正成为全球公认的健康问题。方法：利用 PubMed 和 Google Scholar 数据库检索有关维生素 D 和相关疾病的文献：利用 PubMed 和 Google Scholar 数据库搜索有关维生素 D 和相关疾病的文献：结果：25-（OH）维生素 D 值的升高与维生素 D 缺乏有关，也与死亡和心脏病风险的升高有关。另一方面，对维生素 D 干预和试验进行的荟萃分析发现，胰岛素敏感性、血脂指标或血压没有发生实质性变化，这导致维生素 D 缺乏与心血管疾病之间存在关联：在这篇综述中，我们介绍了维生素 D 治疗对各种心血管疾病和糖尿病影响的最新研究，并解释了其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current diabetes reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

6.30

自引率

0.00%

发文量

158

期刊介绍： Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.