Congenital malformations of the urinary system as visceral markers of undifferentiated connective tissue dysplasia.

IF 2.6 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Postgraduate Medicine Pub Date : 2023-01-01 DOI:10.1080/00325481.2022.2131439
Nataliia Lukianenko, Zhansulu Nurgaliyeva, Olha Astapieva, Viktor Starenkiy, Nataliia Pidchenko
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Abstract

Objective: The relevance of this study is conditioned by the need for urgent search and implementation of effective methods of treatment of urinary system diseases in people of different ages, as well as addressing issues of quality treatment of connective tissue diseases in general and its dysplasia in particular. The aim of the article is to identify congenital defects as visceral markers of connective tissue dysplasia.

Methods: The methodology of this study includes a survey of a group of children with considerable problems in the development and functioning of the urinary system at the age of 2 weeks to 3 years, in order to qualitatively select and determine the most effective methods of treatment. Children who took part in this study had a set of phenotypic and clinical properties of undifferentiated connective tissue dysplasia.

Results: The considerable prevalence of undifferentiated connective tissue dysplasia in young children with congenital malformations of the urinary system, especially in children with abnormal development and functioning of kidney tissue, which substantially influences the course of the disease was determined. Also, treatment of undifferentiated connective tissue dysplasia was predicted.

Conclusions: It was concluded that the presence of a malformation of the urinary system, which is acquired by a child from birth, can be considered as a visceral manifestation of undifferentiated connective tissue dysplasia.

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泌尿系统先天性畸形作为未分化结缔组织发育不良的内脏标志。
目的:本研究的相关性取决于迫切需要寻找和实施治疗不同年龄人群泌尿系统疾病的有效方法,以及解决结缔组织疾病特别是其异常增生的质量治疗问题。本文的目的是确定先天性缺陷作为结缔组织发育不良的内脏标记。方法:本研究的方法学包括对一组在2周至3岁的泌尿系统发育和功能方面存在相当大问题的儿童进行调查,以定性地选择和确定最有效的治疗方法。参加本研究的儿童具有一组未分化结缔组织发育不良的表型和临床特征。结果:在患有先天性泌尿系统畸形的幼儿中,特别是在肾脏组织发育和功能异常的儿童中,未分化结缔组织发育不良的发生率相当高,这对疾病的病程有很大的影响。同时,预测未分化结缔组织发育不良的治疗。结论:结论是,儿童出生时获得的泌尿系统畸形可以被认为是未分化结缔组织发育不良的内脏表现。
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来源期刊
Postgraduate Medicine
Postgraduate Medicine 医学-医学:内科
CiteScore
6.10
自引率
2.40%
发文量
110
审稿时长
6-12 weeks
期刊介绍: Postgraduate Medicine is a rapid peer-reviewed medical journal published for physicians. Tracing its roots back to 1916,  Postgraduate Medicine  was established by Charles Mayo, MD, as a peer-to-peer method of communicating the latest research to aid physicians when making treatment decisions, and it maintains that aim to this day. In addition to its core subscriber base, Postgraduate Medicine is distributed to hundreds of US-based physicians within internal medicine and family practice.
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