Myrtenol Ameliorates Recognition Memories' Impairment and Anxiety-Like Behaviors Induced by Asthma by Mitigating Hippocampal Inflammation and Oxidative Stress in Rats.

IF 2.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Neuroimmunomodulation Pub Date : 2023-01-01 Epub Date: 2023-01-19 DOI:10.1159/000528626

Mohammad Abbas Bejeshk, Amir Hashem Aminizadeh, Elham Jafari, Sina Motamedi, Iman Zangiabadi, Ahmad Ghasemi, Mazyar Fathi, Akram Nezhadi, Faezeh Akhgarandouz, Fatemeh Bejeshk, Leila Mohammadi, Fatemeh Mohammadi, Mohammad Amin Rajizadeh

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引用次数: 7

Abstract

Introduction: Asthma is related to neurochemical alterations which affect brain functions and lead to anxiety and cognitive dysfunctions. Myrtenol has sparked considerable interest due to its pharmacological effects, especially for the remediation of chronic disorders. Thus, the present research was designed to evaluate the impacts of myrtenol on anxiety-like behaviors, cognitive declines, inflammation, and oxidative stress in the hippocampus of asthmatic rats.

Methods: Rats were allocated to five groups: control, asthma, asthma/vehicle, asthma/myrtenol, and asthma/budesonide. Asthma was elicited in the rats by ovalbumin, and the animals were then exposed to myrtenol inhalation. Anxiety-like behavior and memory were assessed by elevated plus maze (EPM) and novel object and location recognition tests. Interleukins (interleukin-6, -17, and -10), tumor necrosis factor α (TNF-α), and oxidative stress biomarkers such as malondialdehyde (MDA), superoxide dismutase (SOD), Glutathione peroxidase (GPX), and total antioxidant capacity (TAC) in the hippocampus were assessed by the ELISA method.

Results: The levels of IL-6, IL-17, TNF-α, and MDA decreased, but GPX, SOD, and TAC levels increased in the hippocampus of asthmatic animals due to myrtenol inhalation.

Conclusion: Myrtenol diminished asthma-induced anxiety-like behaviors and cognitive deficits in asthmatic rats; these effects might have been typically mediated by a reduction in inflammation and oxidative stress.

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通过减轻大鼠海马炎症和氧化应激减轻哮喘引起的识别记忆障碍和焦虑行为

简介哮喘与神经化学物质的改变有关，这种改变会影响大脑功能，导致焦虑和认知功能障碍。由于其药理作用，尤其是在缓解慢性疾病方面的药理作用，桃烯酚引发了人们的极大兴趣。因此，本研究旨在评估肉豆蔻醇对哮喘大鼠海马中焦虑样行为、认知能力下降、炎症和氧化应激的影响：大鼠被分为五组：对照组、哮喘组、哮喘/车辆组、哮喘/肉豆蔻醇组和哮喘/布地奈德组。用卵清蛋白诱发大鼠哮喘，然后让大鼠吸入麦考酚。焦虑样行为和记忆通过高架加迷宫（EPM）和新物体及位置识别测试进行评估。白细胞介素（白细胞介素-6、白细胞介素-17和白细胞介素-10）、肿瘤坏死因子α（TNF-α）以及氧化应激生物标志物，如海马中的丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）和总抗氧化能力（TAC），均通过酶联免疫吸附法进行了评估：结果：哮喘动物海马中的IL-6、IL-17、TNF-α和MDA水平下降，但GPX、SOD和TAC水平上升：结论：肉毒酚可减轻哮喘诱发的哮喘大鼠焦虑样行为和认知障碍；这些影响可能主要是通过减少炎症和氧化应激介导的。

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来源期刊

Neuroimmunomodulation 医学-免疫学

CiteScore

3.60

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.